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Novel polysaccharide antibacterial mouthwash and preparation method thereof

A technology for mouthwash and polysaccharide, which is used in local antibacterial agents, oral care, pharmaceutical formulations, etc., can solve the problems that the extraction process is not easy to supervise, cannot determine allergens, and is prone to allergic reactions, and achieves excellent bacteriostatic effect, Low cost, enhanced antibacterial efficacy

Active Publication Date: 2018-03-30
江苏开源康达医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composition of propolis raw materials is complex, and people with allergies are prone to allergic reactions and cannot determine the allergen. In addition, the propolis extraction process is not easy to supervise. Hormone substances, which have a certain dissolving effect on tooth enamel, will lead to the dissolution of calcium in teeth

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A novel polysaccharide antibacterial mouthwash and a preparation method thereof, the preparation steps of which are:

[0031] (1) Add 1% carboxymethyl chitosan directly into the dissolving kettle, dissolve it with purified water, open the incubator, and mechanically stir at a temperature of T=40~50°C until all the carboxymethyl chitosan is dissolved. dissolve;

[0032] (2) directly join in the dissolving kettle after dissolving 1% propolis with ethanol, guarantee that the solution is in a uniform state;

[0033] (3) using sodium hexametaphosphate as an acid-base regulator to adjust the pH value of the solution obtained in step (2) to 5.0 to 6.5;

[0034] (4) Add 0.5% Chinese herbal medicine concentrate, 0.2% sodium alginate, and 0.01% peppermint oil to the solution obtained in step (3), adjust the temperature to 30-40°C, and continue to stir and mix evenly;

[0035] (5) The solution obtained in step (4) is sent to the next step for subpackaging, and after being tested...

Embodiment 2

[0038] A novel polysaccharide antibacterial mouthwash and a preparation method thereof, the preparation steps of which are:

[0039] (1) Add 2% carboxymethyl chitosan directly into the dissolving kettle, dissolve it with purified water, open the incubator, and mechanically stir at a temperature of T=40~50°C until all the carboxymethyl chitosan is dissolved. dissolve;

[0040] (2) directly join in the dissolution kettle after dissolving 3% propolis with ethanol, guarantee that the solution is in a uniform state;

[0041] (3) using sodium hexametaphosphate as an acid-base regulator to adjust the pH value of the solution obtained in step (2) to 5.0 to 6.5;

[0042] (4) Add 0.5% Chinese herbal medicine concentrate, 0.2% sodium alginate, and 0.01% peppermint oil to the solution obtained in step (3), adjust the temperature to 30-40°C, and continue to stir and mix evenly;

[0043] (5) The solution obtained in step (4) is sent to the next step for subpackaging, and after being teste...

Embodiment 3

[0046] A novel polysaccharide antibacterial mouthwash and a preparation method thereof, the preparation steps of which are:

[0047] (1) Add 3% carboxymethyl chitosan directly into the dissolving kettle, dissolve it with purified water, open the incubator, and mechanically stir at a temperature of T=40~50°C until the carboxymethyl chitosan is completely dissolved. dissolve;

[0048](2) directly join in the dissolution kettle after dissolving 5% propolis with ethanol, guarantee that the solution is in a uniform state;

[0049] (3) using sodium pyrophosphate as an acid-base regulator to adjust the pH value of the solution obtained in step (2) to 5.0 to 6.5;

[0050] (4) Add 1% Chinese herbal medicine concentrate, 0.5% sodium alginate, and 0.03% peppermint oil to the solution obtained in step (3), adjust the temperature to 30-40°C, and continue to stir and mix evenly;

[0051] (5) The solution obtained in step (4) is sent to the next step for subpackaging, and after being teste...

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PUM

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Abstract

The invention discloses a novel polysaccharide antibacterial mouthwash and a preparation method thereof. The novel polysaccharide antibacterial mouthwash comprises the active ingredients of carboxymethyl chitosan and propolis and further comprises a Chinese herbal medicine concentrate, sodium alginate, oleum menthae, a pH modifier, ethanol and purified water. The preparation method comprises the following steps: quantitatively adding carboxymethyl chitosan and a propolis and ethanol solution, and heating for dissolution; after the solution is cooled down, adding the Chinese herbal medicine concentrate, sodium alginate, oleum menthae and the pH modifier, supplementing purified water to obtain the total amount, and obtaining the novel polysaccharide antibacterial mouthwash after measuring the pH value. The novel polysaccharide antibacterial mouthwash has the effects of cleaning the oral cavity and resisting bacteria to protect teeth, meanwhile, reduces the allergy risk caused by propolis, has a very unique Chinese herbal medicine fragrance, is added with no synthetic essences, is safer and more healthy, is simple in preparation method, low in cost, lasting and effective in antibacterial effect, free from toxic and side effects on a human body and comfortable in taste.

Description

technical field [0001] The invention belongs to the field of medical health products, in particular to a novel polysaccharide antibacterial mouthwash and a preparation method thereof. Background technique [0002] In recent years, the incidence of oral diseases has been extremely high. With the improvement of people's living standards and health awareness, the prevention and treatment of oral diseases and the protection of teeth have become more and more important. The traditional oral care methods of toothpaste and toothbrushing are inconvenient to use. If it is not timely, not thorough, and has the disadvantages of wearing teeth, it is difficult to meet people's oral cleaning requirements. [0003] Oral disease is a common disease, mainly manifested as gingivitis, dental plaque, oral ulcers, periodontitis, aphtha of the mouth, bad breath and other symptoms. After the harmful bacteria produced by oral diseases enter the blood, they will have varying degrees of impact on th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/98A61K8/9789A61K8/92A61K8/73A61Q11/00A61P31/02
CPCA61K8/733A61K8/736A61K8/922A61K8/97A61K8/988A61K2800/52A61Q11/00
Inventor 孙开源
Owner 江苏开源康达医疗器械有限公司
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