Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of recycling method of phenylglycine in cephalexin crystallization mother liquor

A technology of phenylglycine and crystallization mother liquor, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of unrecyclable, waste of resources, waste of phenylglycine, etc., and achieve environmental protection and reduce processing costs , the effect of reducing production costs

Active Publication Date: 2019-01-25
XIAMEN TQX MEMBRANE TECH
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current solution for the treatment of cephalexin mother liquor is to use organic solvents for extraction and chelation to extract cephalexin. This method not only wastes phenylglycine, but also consumes a lot of organic solvents, which cannot be discharged to environmental protection for biochemical treatment. Solid waste can only be formed by evaporation. Reprocessing solid waste, this method is too costly and a waste of resources
[0003] Patent application CN103788115A discloses a method for concentrating cephalexin by an integrated membrane method and a concentrated enzyme method. Through fine filtration, ultrafiltration membrane, nanofiltration and reverse osmosis, the original cephalexin solution is concentrated more than 10 times, but it only reaches For the purpose of concentration, there is no specific method for how to deal with the concentrated solution; patent CN104058537B discloses a method for treating wastewater from cephalexin enzymatic synthesis of mother liquor, which can only recycle water and inorganic salt crystals in the mother liquor, and there are still other value components of which cannot be recovered

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of recycling method of phenylglycine in cephalexin crystallization mother liquor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 100L of enzymatic cephalexin crystallization mother liquor, wherein the cephalexin content is 15-18g / L, add 10kg of penicillin G acylase to it, adjust pH=7, and react for 2h at a temperature of 40°C to crack it to obtain Lysis solution of 7-aminodesacetoxycephalosporanic acid and phenylglycine, wherein phenylglycine is 15-18g / L, cephalexin content is less than 1g / L, ammonium sulfate is about 100g / L, conductivity is about 10ms / cm, Biochemical oxygen consumption (COD) is about 200000mg / L, ammonia nitrogen (NH 3 -N) is about 30000mg / L, pH=6-7. Use dilute sulfuric acid to adjust the pH of the lysate to pH=4, and keep the temperature at 30° C. for later use.

[0032] Take 100L of the lysate and carry out centrifugation at a speed of 4000r / min to obtain 1.02kg of 7-aminodesacetoxycephalosporanic acid crystals and about 100L of the centrifuged liquid, which is filtered through a 2KDa-20KDa roll-type ultrafiltration membrane. The operating pressure is 3bar and the temper...

Embodiment 2

[0036]Take 100 L of enzymatic cephalexin crystallization mother liquor, wherein the cephalexin content is 15-18 g / L, add 10 kg of penicillin G acylase to it, adjust pH=5 with dilute sulfuric acid, and react for 5 hours at a temperature of 25° C. to make it Cleavage to obtain a lysate containing 7-aminodesacetoxycephalosporanic acid and phenylglycine, wherein the phenylglycine is 15-18g / L, the cephalexin content is less than 1g / L, the ammonium sulfate is about 100g / L, and the conductivity is about 10ms / cm, biochemical oxygen consumption (COD) is about 200000mg / L, ammonia nitrogen (NH 3 -N) is about 30000mg / L, pH=6-7. Use dilute sulfuric acid to adjust the pH of the lysate to pH=3, and keep the temperature at 25° C. for later use.

[0037] Take 100L of the lysate and carry out centrifugation at a speed of 8000r / min to obtain 1.35kg of 7-aminodesacetoxycephalosporanic acid crystals and about 100L of the centrifuged liquid. The centrifuged liquid is filtered through a roll-type ...

Embodiment 3

[0041] Take 100L of enzymatic cephalexin crystallization mother liquor, wherein the cephalexin content is 15-18g / L, add 10kg of penicillin G acylase to it, adjust the pH=9 with diluted ammonia water, and react for 1h at a temperature of 50°C. Make it crack to obtain the lysate containing 7-aminodesacetoxy cephalosporanic acid and phenylglycine, wherein phenylglycine 15-18g / L, cephalexin content is less than 1g / L, ammonium sulfate is about 100g / L, conductivity is about 10ms / cm, biochemical oxygen consumption (COD) is about 200000mg / L, ammonia nitrogen (NH 3 -N) is about 30000mg / L, pH=6-7. Use dilute sulfuric acid to adjust the pH of the lysate to pH=4, and keep the temperature at 30° C. for later use.

[0042] Get 100L of lysate and carry out centrifugation, rotating speed is 5000r / min, obtain 7-aminodesacetoxy cephalosporanic acid crystal 1.02kg and centrifuged liquid about 100L, centrifuged liquid is through membrane filtration (membrane core is roll type ultrafiltration mem...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for recycling phenylglycine in cefalexin crystallization mother liquid. The method comprises the steps of pyrolysis, centrifugation, pretreatment, desalination and nano-filtration concentration. The method provided by the invention solves the difficulty that wastewater containing cefalexin cannot be directly treated biochemically, and phenylglycine recovered by the method can be directly applied to subsequent production. According to the method disclosed by the invention, an organic solvent is not used, and the production cost is reduced, so that the method is beneficial for environmental protection and is a green and efficient recovery method.

Description

technical field [0001] The invention relates to a process for recycling organic mother liquor, in particular to a method for recycling phenylglycine in cephalexin crystallization mother liquor. Background technique [0002] Cephalexin is a broad-spectrum antibiotic. The cephalexin mother liquid wastewater produced during its production process contains a large amount of organic matter, inorganic salts and a small amount of cephalexin products. This kind of organic waste water with high salt content is difficult to use conventional biochemical methods. Or simple nanofiltration treatment and recovery. The current solution for the treatment of cephalexin mother liquor is to use organic solvents for extraction and chelation to extract cephalexin. This method not only wastes phenylglycine, but also consumes a lot of organic solvents, which cannot be discharged to environmental protection for biochemical treatment. Solid waste can only be formed by evaporation. The cost of reproc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C12P35/02C12P13/04C07C229/36C07C227/40C07D501/22C07D501/12
CPCC07C227/40C07D501/12C07D501/22C12P13/04C12P35/02C07C229/36
Inventor 吴洪溪
Owner XIAMEN TQX MEMBRANE TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com