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Calcitriol capsule type drop and preparation method thereof

A technology of calcitriol and calciferol, which is applied in capsule delivery, bone diseases, and pharmaceutical formulations, can solve problems such as difficulty in taking medicine, and achieve high safety, strong pertinence, and the effect of promoting calcium absorption

Inactive Publication Date: 2016-03-02
HENAN TAIFENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The object of the present invention is to overcome the deficiency of the difficulty in taking medicine of existing swallowing patients, and to provide a calcitriol capsule drop and a preparation method thereof. The calcitriol capsule drop prepared by the present invention can effectively treat bone Calcium supplementation for loose patients, and has the characteristics of simple preparation method and convenient administration for children and other patients with dysphagia

Method used

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  • Calcitriol capsule type drop and preparation method thereof

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Embodiment 1

[0021] A calcitriol capsule type drops, the composition is as follows: calcitriol, butylhydroxyanisole, dibutylhydroxytoluene, medium chain triglyceride. The content of calcitriol is 0.25 micrograms per 0.1 ml of content.

[0022] A method for preparing calcitriol capsule-type drops. The steps of the method are as follows:

[0023] (1). Weigh calcitriol, butylated hydroxyanisole, dibutylhydroxytoluene, and soybean oil according to the prescription amount. The content of calcitriol is 0.25 micrograms per 0.1 ml of content, and stir and mix well to form a uniform and stable The mixing temperature is 0 to 4 degrees Celsius, and the mixer is a sealed container filled with nitrogen without air residue;

[0024] (2). Add titanium dioxide, medicinal pigments, iron oxide, sorbitol, glycerin, methyl paraben and propyl paraben into the gel tank, heat it to 40-60 degrees Celsius, put in gelatin, and heat To 70-90 degrees Celsius, stir for 30-40 minutes, stand for 30-60 minutes, filter, screen...

Embodiment 2

[0031] A method for preparing calcitriol capsule-type drops. The steps of the method are as follows:

[0032] (1). Weigh calcitriol, butylated hydroxyanisole, dibutylhydroxytoluene, and medium-chain triglycerides according to the prescription amount, where the content of calcitriol is 0.5 micrograms per 1.0 ml of content, stir and mix well, A uniform and stable content is formed, the mixing temperature is 0-4 degrees Celsius, the mixer is a sealed container filled with nitrogen, and there is no air residue;

[0033] (2). Add titanium dioxide, medicinal pigments, iron oxide, sorbitol, glycerin, methyl paraben and propyl paraben into the gel tank, heat it to 40-60 degrees Celsius, put in gelatin, and heat To 70-90 degrees Celsius, stir for 30-40 minutes, stand for 30-60 minutes, filter, screen size 120-140 mesh, glue liquid in the storage tank 55 degrees Celsius heat preservation for use;

[0034] (3). Put the content obtained in step (1) and the glue obtained in step (2) into a roll-...

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Abstract

The present invention relates to a calcitriol capsule type drop and a preparation method thereof. The calcitriol capsule type drop comprises contents and a capsule shell, wherein the contents comprise calcitriol, butyl hydroxyanisole, butylated hydroxytoluene, and grease, and the capsule shell comprises gelatin, titanium dioxide, sunset yellow, iron oxide, water, sorbitol and glycerin. Compared with the drop in the prior art, the drop of the present invention has characteristics of high safety, easy use, strong targeting property, and the like.

Description

Technical field [0001] The invention belongs to the field of calcitriol preparations, and relates to calcium supplement drugs, in particular to a calcitriol capsule-type drop and a preparation method thereof. technical background [0002] Calcitriol is one of the most important metabolically active products of vitamin D3 in the human body. Normally, calcitriol is synthesized in the kidney from its precursor 25-hydroxycholesterol. The daily physiological synthesis of calcitriol in the human body is about 0.5-1.0ug. During the period of active bone formation, its synthesis volume also slightly increased. Calcitriol can promote the absorption of calcium in the intestines and regulate bone calcification. At present, no calcitriol capsule drops are on the market at home and abroad, and the only available dosage forms are raw materials, soft capsules, injections, capsules and ointments. As a calcium supplement, calcitriol occupies a certain position in the calcium supplement market....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/593A61P19/10
Inventor 沙薇张胜华郑晔
Owner HENAN TAIFENG BIOTECH CO LTD
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