Medicine composition for treating cutaneous pruritus disease and application thereof

A technology of skin itching and composition, applied in the field of pharmacy, can solve problems such as limited effect, and achieve the effect of significant effect and elimination of redness and swelling

Inactive Publication Date: 2016-03-02
CHENGDU HAOJIAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, single tea tree oil formulations have limited efficacy in treating itchy skin conditions

Method used

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  • Medicine composition for treating cutaneous pruritus disease and application thereof
  • Medicine composition for treating cutaneous pruritus disease and application thereof
  • Medicine composition for treating cutaneous pruritus disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036] The preparation method of the pharmaceutical composition for treating skin pruritus of the present invention can adopt the following steps:

[0037] Under the condition that the temperature does not exceed 95℃, stir and mix or emulsify the tea tree oil, skin refreshing agent and licorice extract with auxiliary materials to obtain component A; under the condition that the temperature does not exceed 95℃, the Sophora flavescens extract or Sophora sphaerocarpa extract is dissolved in water, fully stirred and mixed with auxiliary materials to meet the requirements of the required preparation, and then component A is added, constant volume, stirred or emulsified to obtain the pharmaceutical composition of the present invention for treating skin pruritus;

[0038] Or use the following steps: Stir and mix or emulsify tea tree oil and skin fresheners with excipients at a temperature not exceeding 95°C to obtain component A; at a temperature not exceeding 95°C, extract Sophora flavesc...

Embodiment 1

[0045] Example 1 Preparation of aqua sample

[0046] At room temperature (25±5℃), weigh out 2.0g of tea tree oil, 10.0g of propylene glycol, 5.0g of glycerin, 5.0g of Tween 80, 0.6g of borneol, and 0.4g of vitamin E. Place them in a 250ml beaker and stir slowly. To completely dissolve to obtain composition A, ready for use;

[0047] Weigh 1.0 g of Sophora flavescens extract, 0.3 g of licorice extract, and 0.05 g of EDTA, put them in a 100 ml beaker, add an appropriate amount of purified water, slowly stir until completely dissolved, add dropwise 5% sodium hydroxide solution, and adjust the pH to 6.5, to obtain composition B; the content of the Sophora flavescens extract is based on matrine, and the content of the licorice extract is based on glycyrrhizic acid.

[0048] Under stirring conditions, slowly add composition B to composition A, continue stirring until the mixed solution is completely clear, and make up to 200 grams of purified water to obtain a composition aqueous sample o...

Embodiment 2

[0049] Example 2 Preparation of gel sample

[0050] Under the condition of heat preservation (45±5℃), weigh out 4.0g tea tree oil, 0.4g licorice extract, 10.0g propylene glycol, 5.0g Tween 80, 0.6g peppermint oil, and 2.0g laurin, and place them in 250ml In the beaker, slowly stir until completely dissolved to obtain composition A, ready for use;

[0051] Weigh 0.9g of Carbomer 940, place it in a 250ml beaker, pre-dissolve it with purified water, add dropwise 10% sodium hydroxide solution, adjust the pH to 6.5, add 1.5g of Sophora flavescens extract and 0.05g of EDTA, slowly Stir until it is gel-like to obtain composition B; the content of the Sophora flavescens extract is based on matrine, and the content of the licorice extract is based on glycyrrhizic acid.

[0052] Under stirring conditions, slowly transfer composition B to composition A, continue stirring until the mixed solution is completely mixed, and make up to 200 grams of purified water to obtain a gel sample of the compo...

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Abstract

The invention relates to a medicine composition for treating a cutaneous pruritus disease and an application thereof, and belongs to the technical field of pharmacy. Active ingredients of the medicine composition are prepared from, by weight, 0.5-25 parts of tea tree oil, 0.1-10 parts of radix flavescentis extract or sophora alopecuroide extract and 0.05-5 parts of liquorice extract. The medicine composition has the sterilization function and the anti-inflammatory function; common pathogenic microorganisms such as methicillin-resistant staphylococcus aureus, candida albicans and escherichia coli can be killed or remarkably inhibited in a short period of time; the medicine composition can be directly used for the portion with injured skin; the active components of the medicine composition are all made of natural plants, itching can be rapidly relieved, swelling can be rapidly eliminated, and the effect is remarkable; meanwhile, the medicine composition has anti-bacterial activity and sterilizing activity, is safe, nontoxic, free of pollution to clothes and skin and free of human-body skin irritation and human-body skin sensitization, and can be used for a long time.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating skin pruritus and its application, and belongs to the technical field of pharmacy. Background technique [0002] Skin itching is a common symptom in daily life, involving all exposed parts of the human body from the scalp to the anus and the soles of the feet. In medical clinical practice, corticosteroid preparations such as hydrocortisone or dexamethasone (for example: Piyanping) are commonly used to relieve itching, but they have significant side effects. Long-term use seriously interferes with calcium and phosphorus metabolism in the body. More than five days, children are best not to use it. Traditional Chinese patent medicines for external use mainly include calamine liniment, dehumidification and antipruritic ointment, antipruritic anti-inflammatory water, etc., which have limited antipruritic effect, extensive product form, inconvenient use, and easy to contaminate skin and clothing....

Claims

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Application Information

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IPC IPC(8): A61K36/61A61P17/04
CPCA61K9/0014A61K9/06A61K9/08A61K9/107A61K36/484A61K36/489A61K36/61A61K47/10A61K47/12A61K47/14A61K47/22A61K47/26A61K47/36A61K47/44A61K2300/00Y02A50/30
Inventor 毛宇张小红
Owner CHENGDU HAOJIAN BIOTECH CO LTD
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