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Nano magnetotherapy externally used gel for treating acne vulgaris, and preparation method and application of nano magnetotherapy gel

A nano-magnetic and gel technology, applied in the field of skin diseases, can solve the problems of strong skin irritation, liver and kidney toxicity, and dermatitis induced by peroxyaniline, so as to reduce toxic side effects and adverse reactions, and reduce bacterial drug resistance. , the effect of reducing the probability of occurrence

Active Publication Date: 2016-03-09
徐州瀚祥生物科技研究院有限公司
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

However, the daily dose of oral minocycline is at least 100 mg, which is highly toxic to the liver and kidneys, while topical minocycline will produce drug resistance and cannot be used for a long time; retinoic acid drugs are easy to decompose when exposed to light and oxidants, and induce dermatitis; Salicylic acid compounds and strong oxidant anilyl peroxide are highly irritating to the skin

Method used

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  • Nano magnetotherapy externally used gel for treating acne vulgaris, and preparation method and application of nano magnetotherapy gel
  • Nano magnetotherapy externally used gel for treating acne vulgaris, and preparation method and application of nano magnetotherapy gel
  • Nano magnetotherapy externally used gel for treating acne vulgaris, and preparation method and application of nano magnetotherapy gel

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Experimental program
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Embodiment 1

[0024] Embodiment 1: Nanoscale iron oxide-minocycline nanoscale gel

[0025] 1. Preparation of nano-zinc oxide reverse micellar microemulsion

[0026] Accurately configure 1mol / L zinc acetate aqueous solution for use, then weigh 0.3655g of cetyltrimethylammonium bromide (CTAB) and add it to 10ml of cyclohexane; Propanol (IPA), continue to stir until a uniform milky white emulsion is formed, continue to stir, and add zinc acetate aqueous solution until the solution system is instantly clear, indicating that the two systems have formed a reverse micellar microemulsion, continue to drop zinc acetate solution to keep clarification stop.

[0027] 2. Preparation of nano-iron oxide-nano-zinc oxide-minocycline albumin nanoparticles

[0028] 1) Take 0.1ml of minocycline solution with a concentration of 50% in 0.9ml buffer solution to form a pH=8 mixed solution containing 5% drug, add albumin with a volume ratio of 0.5% of the mixed solution, that is, 5mg albumin, and place in into t...

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Abstract

The invention discloses a nano magnetotherapy gel for treating acne vulgaris, and a preparation method and the application of the nano magnetotherapy topical gel. The nano magnetotherapy gel is prepared from the following raw materials in percentage by weight: 0.05 percent to 0.5 percent (W / W) of medicine-minocyline, 20 percent to 25 percent (W / W) of biodegradable polymer materials, 0.2 percent to 4 percent (W / W) of nano metal oxide, 60 percent to 79 percent (W / W) of CBM-940 (Carbopol-940) and 0.01 percent to 0.02 percent (W / W) of chemical crosslinking agent; the biodegradable polymer materials are used for wrapping the minocyline and the nano metal oxide to prepare metal oxide-minocyline nanoparticles, and the CBM-940 is used as a substrate to prepare an sustained-released gel; the nano metal oxide is a mixture of nano iron oxide and nano zinc oxide.

Description

technical field [0001] The invention relates to clinical research on the synergistic effect of nanometer materials and antibacterial drugs, and is used for preparing dermatological medicines, especially for treating skin diseases such as acne. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous unit. It is prone to occur in adolescents and tends to leave scars after healing. It has a great psychological and social impact on adolescents. It is estimated that the global demand for acne treatment drugs can reach a market value of about 1.87 billion pounds (about 19 billion yuan) per year. The pathogenesis of acne is relatively complicated. Current studies believe that hair follicles contain Malassezia furfur, coagulase-negative staphylococcus, Gram-negative bacilli, and Propionibacterium acnes, among which the lipase produced by Propionibacterium acnes decomposes sebum to produce Free fatty acids, while chemoattracting inflammatory ce...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K33/30A61K47/32A61K47/42A61K47/36A61K47/38A61P17/10A61P31/04A61K31/65
CPCA61K9/0014A61K9/06A61K31/65A61K33/30A61K47/32A61K47/36A61K47/38A61K47/42A61K2300/00
Inventor 牟杰裴冬生赵伯南陆健吾徐铭递高干高军红姜力群
Owner 徐州瀚祥生物科技研究院有限公司
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