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Application of hance brandisia herb tablets to preparing medicine for suppressing proliferation of fibroblast L929

A fibroblast and cell proliferation technology, which is applied in the field of preparation of honey bucket flower slices, can solve the problems of rough technology, backwardness, and large dosage of patients

Inactive Publication Date: 2016-03-09
JINAN XINSHIDAI MEDICINE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the application of honey bucket flower slices in the preparation of drugs for inhibiting the proliferation of mouse fibroblast cells L929 cells, and there is no report on the use of supercritical extraction in the extraction and preparation of honey bucket flower slices. The traditional water decoction method has rough and backward technology and many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take honey bucket flower 1700g, add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 850min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 400 tablets, each weighing 0.50g.

[0025] After testing, the content of ergosteroside in the finished product is 2.61mg / tablet.

Embodiment 2

[0027] Take honey bucket flower 1700g, add to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 900min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 400 tablets, each weighing 0.50g.

[0028] After testing, the content of ergosteroside in the finished product is 1.58mg / tablet.

Embodiment 3

[0030] Take honey bucket flower 1700g, add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 60°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 800min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 400 tablets, each weighing 0.50g.

[0031] After testing, the content of ergosteroside in the finished product is 2.04mg / tablet.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to an application of hance brandisia herb tablets to preparing medicine for suppressing proliferation of fibroblast L929 and a preparing method of the hance brandisia herb tablets. The hance brandisia herb tablets are prepared with 1,700 g of hance brandisia herbs as raw medicinal materials in a supercritical-extraction mode, and the content of acteoside is greatly increased accordingly.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of honey bucket flower slices in the preparation of drugs for inhibiting the proliferation of fibroblast L929 cells and the preparation method of honey bucket flower slices. Background technique [0002] Honey bucket flower granule standard number WS-11440 (ZD-1440)-2002, recorded in the National Compilation of Chinese Patent Medicine Standards Internal Medicine Hepatobiliary Subvolume. Made from 1700g of honey pail flower as raw material medicine, it has the functions of clearing heat and detoxifying, dehumidifying and promoting gallbladder, and it is used for acute and chronic hepatitis caused by damp heat in liver and gallbladder. [0003] In the prior art, there is no report on the application of honey bucket flower slices in the preparation of drugs for inhibiting the proliferation of mouse fibroblast cells L929 cells, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/80A61K9/20A61K47/36A61P35/00
CPCA61K36/80A61K9/2059A61K2236/37
Inventor 张静
Owner JINAN XINSHIDAI MEDICINE SCI & TECH
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