Medicine preparation for treating brain diseases

A technology for pharmaceutical preparations and diseases, applied in the field of pharmaceutical preparations for treating brain diseases, can solve the problems of large dosage, poor treatment effect, obvious toxic and side effects, etc., and achieves an increase in the amount of drugs entering the brain, obvious effects, and reduced toxic and side effects. Effect

Inactive Publication Date: 2016-03-09
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] One of the objectives of the present invention is to provide a pharmaceutical preparation for the treatment of brain diseases in order to solve the problems of large dosage, obvious toxic and side effects and poor therapeutic effect of the drug preparations for treating brain diseases in the prior art. Traditional Chinese medicines, chemical drugs and biomacromolecular drug preparations for the treatment of brain diseases are administered on the skin surface, intradermal and subcutaneous of the face, oral cavity and nasal cavity, so that the drugs can pass through the skin of the trigeminal nerve, facial nerve, striatum, olfactory brain, Administration of drugs into the brain through the hippocampus or medulla oblongata promotes the entry of certain drugs that cannot pass through the blood-brain barrier into the brain, adding new ways and new methods of treating brain diseases that are not currently available

Method used

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  • Medicine preparation for treating brain diseases
  • Medicine preparation for treating brain diseases
  • Medicine preparation for treating brain diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A pharmaceutical preparation for treating brain diseases, the administration method comprising the following steps: making the drug into a targeted preparation that enters the brain through the trigeminal nerve, which is an externally applicable and injectable hydrogel, the components of which are And mass percentage content comprises:

[0035]

[0036] The above-mentioned pharmaceutical preparation for treating brain diseases, its preparation method comprises the following steps: at a temperature of 20°C, dissolving poloxamer with a mass percentage of 23% in water, adding 0.1% aFGF to the poloxamer In the Loxamer aqueous solution, continue to add 5% Tween 80, 0.1% propylene glycol, 5% triethanolamine, 1.5% hyaluronic acid, 1.5% lanosterol, add deionized water to make up to 100%, and increase the temperature to At 37°C, it forms a non-flowing gel.

Embodiment 2

[0038] A pharmaceutical preparation for treating brain diseases, the administration method comprising the following steps: making the drug into a targeted preparation that enters the brain through the trigeminal nerve, which is an externally applicable and injectable hydrogel, the components of which are And mass percentage content comprises:

[0039]

[0040]

[0041] Make up to 100% with deionized water.

[0042] Disperse the carbomer with a mass percentage of 2% in water, heat it appropriately, and dissolve it completely into a carbomer aqueous solution. Add a mass percentage of 4% glycerin, 3% sodium lauryl sulfate, 1% Polyethylene glycol 1% lanosterol and 1% hyaluronic acid, uniformly dispersed, adding mass percentage is 1% BFGF, uniformly dispersed, at room temperature, adding mass percentage is 2% triethanolamine stearate , add deionized water to make up to 100%, and become a stagnant gel.

Embodiment 3

[0044] A pharmaceutical preparation for treating brain diseases, the administration method comprising the following steps: making the drug into a targeted preparation that enters the brain through the trigeminal nerve, which is an externally applicable and injectable hydrogel, the components of which are And mass percentage content comprises:

[0045]

[0046] Take 2.5% by mass of methyl cellulose in a mortar, add 5% by mass of glycerin, 0.1% of aluminum distearate and grind it evenly, add 1% by mass of lanosterol and 1% of transparent Grind the hyaluronic acid, add deionized water to 100% and grind evenly, add the prescribed amount of medicine, stir evenly, and form a non-flowing gel.

[0047] A pharmaceutical preparation for treating brain diseases described in Examples 1-3, wherein the active ingredients can also be EPO and nerve growth factor for treating brain diseases;

[0048] The material for the hydrogel matrix can also be one of hypromellose and gelatin;

[0049...

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Abstract

The invention relates to a medicine preparation, in particular to a medicine preparation for treating brain diseases. The medicine preparation is prepared from effective components and auxiliary materials. The effective components comprises one or a combination of Eevans blue, adriamycin, camptothecin, paclitaxel, camptothecin with the mass percentage different from the previous camptothecin, podophyllotoxin, echidnotoxin, indomethacin, guaianolide, parthenolide, arglabin, aFGF, BDNF, NGF, EPO, insulin, insulin amyloids, oxytocin or GLP-1. The invention discloses a medicine delivery method for treating brain diseases. The method has the advantages of innovativeness, high efficiency and targeting performance, toxic and side effects are reduced, a blood brain barrier way is not used, the amount of medicine entering the brain is increased, and the brain disease treatment effect is remarkable.

Description

technical field [0001] The invention relates to a drug administration method, in particular to a pharmaceutical preparation for treating brain diseases. Background technique [0002] Brain diseases such as brain tumors, viral infections, and trauma to the central nervous system are extremely harmful to human health. However, due to the existence of the blood-brain barrier (BBB), the natural physiological barrier of brain tissue, most small molecule drugs and almost all macromolecular drugs cannot enter the brain tissue smoothly, which limits the treatment of brain diseases. . Therefore, the promotion of drugs, especially macromolecular drugs, into the brain has become a key problem to be solved urgently, and it is also a trend in the development of international encephalopathy drugs in recent years. [0003] Since the drug needs to pass through the BBB to enter the brain through the conventional route, the dosage must be increased, resulting in a higher drug concentration ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/28A61K31/655A61K31/704A61K31/4745A61K31/337A61K31/365A61K31/405A61K38/17A61K38/18A61K38/28A61K38/11A61P25/00A61K38/095
Inventor 杨伟虞希冲赵应征
Owner WENZHOU MEDICAL UNIV
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