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Method for preparing chitosan plasma grafting hyaluronic acid biological hemostasis material

A technology of hyaluronic acid and hemostatic materials, which is applied in the fields of medical formula, drug delivery, medical science, etc., can solve wound inflammation and other problems, and achieve the effect of preventing hemostasis and heat release, good combination effect, and no toxic side effects

Inactive Publication Date: 2016-03-09
CHANGZHOU SIYU ENVIRONMENTAL PROTECTION MATERIAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The technical effect that this invention uses hydroxypropyl methyl cellulose (HM) or other polymers with high molecular weight called glucosaminoglycan are added to improve its ability to stop bleeding quickly while also reducing tissue damage caused during medical procedures such as ablation surgery. This results in fewer complications for patients who have had their blood vessels treated beforehand because they were able to absorb enough fluid afterward when it was stopped.

Problems solved by technology

The technical problem addressed by this patented technology relates to finding ways to improve quick stopping or arresting bleeds during emergency situations like firefighting operations without leaving any residues that could harm other people's healthy skin cells. Current methods involve applying pressure directly onto damaged areas but they often result in excessive damage due to lack of effective contact between the affected area and the applied force. This results in increased risk of secondary injury when reapplying these techniques over time.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] First select 10g of chitosan, put it in a 1L flask, then continue to add 200mL of formic acid solution with a mass concentration of 15%, heat the reaction in an oil bath at 85°C for 2h, and place it at 35°C after the reaction is completed Rotary evaporation to 1 / 10 of the original volume prepares the chitosan formic acid concentrate; the chitosan formic acid concentrate prepared above is placed in a 200mL centrifuge tube, and the volume of the chitosan formic acid concentrate Ratio 1:5, absolute ethanol was added to the centrifuge tube, centrifuged at a speed of 4000r / min for 5min, the lower layer was collected and washed twice with absolute ethanol, the precipitated chitosan was collected and vacuum freeze-dried for 6h, Prepare highly water-soluble chitosan; select 5g of highly water-soluble chitosan prepared above, place it in a 1L flask, then continue to add 100mL of distilled water, place it in a 30°C water bath and heat for 25min, after the heating is completed, Co...

example 2

[0021] First select 12g of chitosan, put it in a 1L flask, then continue to add 225mL of formic acid solution with a mass concentration of 15%, heat and react in an oil bath at 87°C for 2.5h, after the reaction is completed, place it at 37°C Rotary evaporation down to 1 / 10 of the original volume prepares the chitosan formic acid concentrate; the chitosan formic acid concentrate prepared above is placed in a 200mL centrifuge tube, and is mixed with absolute ethanol and chitosan formic acid concentrate The volume ratio is 1:5, add absolute ethanol to the centrifuge tube, centrifuge at a speed of 4500r / min for 7min, collect the lower precipitate and wash it twice with absolute ethanol, collect the precipitated chitosan and vacuum freeze-dry it for 7h , to prepare highly water-soluble chitosan; select 5.5g of highly water-soluble chitosan prepared above, place it in a 1L flask, then continue to add 102mL of distilled water, place it in a 35°C water bath and heat for 27min, and wait...

example 3

[0024]First select 15g of chitosan, put it in a 1L flask, then continue to add 250mL of formic acid solution with a mass concentration of 15%, heat the reaction in an oil bath at 90°C for 3h, and place it at 40°C after the reaction is completed Rotary evaporation to 1 / 10 of the original volume prepares the chitosan formic acid concentrate; the chitosan formic acid concentrate prepared above is placed in a 200mL centrifuge tube, and the volume of the chitosan formic acid concentrate Ratio 1:5, add absolute ethanol to the centrifuge tube, centrifuge at a speed of 5000r / min for 10min, collect the lower precipitate and wash with absolute ethanol 3 times, collect the precipitated chitosan and vacuum freeze-dry it for 8h, Prepare highly water-soluble chitosan; select 6g of highly water-soluble chitosan prepared above, place it in a 1L flask, then continue to add 105mL of distilled water, place it in a 40°C water bath and heat for 30min, after the heating is completed, Continue to ad...

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Abstract

The invention relates to a method for preparing a chitosan plasma grafting hyaluronic acid biological hemostasis material, and belongs to the technical field of biological material preparation. According to the problem that due to the fact that a large amount of heat can be emitted after an existing hemostasis material absorbs moisture in blood in the using process, wound inflammation is caused, chitosan and formic acid are heated to be reacted, and activated chitosan is prepared under the action of epoxy chloropropane; afterwards, the chitosan is hydrolyzed so that hyaluronic acid can be prepared, and the biological hemostasis material can be prepared through plasma grafting in the way that the hyaluronic acid is grafted onto the chitosan. By the adoption of the method, the proportion of wound inflammation caused by heating is decreased by more than 80%, the hyaluronic acid is prepared through the chitosan, the hyaluronic acid and the chitosan are good in combination effect and can be absorbed by human bodies completely, and toxic and side effects can be avoided.

Description

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Claims

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Application Information

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Owner CHANGZHOU SIYU ENVIRONMENTAL PROTECTION MATERIAL SCI & TECH
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