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Application of compound VS1 in preparation of anti-non-small cell lung cancer medicine

A non-small cell lung cancer, compound technology, applied in the field of known compounds, can solve problems such as difficult to develop lung cancer therapies or drugs

Active Publication Date: 2016-03-23
BEIJING COMPUTING CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the wide variety of gene variations in the internal cause, it is currently difficult to develop new therapies or drugs that can effectively treat lung cancer

Method used

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  • Application of compound VS1 in preparation of anti-non-small cell lung cancer medicine
  • Application of compound VS1 in preparation of anti-non-small cell lung cancer medicine
  • Application of compound VS1 in preparation of anti-non-small cell lung cancer medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This example verifies the inhibitory effect of compound VS1 of the present invention on non-small cell lung cancer cell lines:

[0030] (1) A549 and MRC-5 adherent cells in the logarithmic growth phase were selected, digested with trypsin, and formulated with DMEM and improved α-MEM medium containing 10% fetal bovine serum to prepare 5×10 4 cells / ml of cell suspension, inoculated in 96-well culture plate, inoculated 200 μl per well, 37°C, 5% CO 2 to cultivate.

[0031] (2) Configure the drug sample mother solution (compound VS1 of the present invention), incubate and shake the drug sample to dissolve with 50% DMSO solution, and configure a solution with a final concentration of 2 mg / ml; and configure a five-fold diluted working solution , the final concentration is 1mg / ml, 200μg / ml, 40μg / ml, 8μg / ml, 160ng / ml, 32ng / ml.

[0032] Prepare positive drug nimustine (a known anti-non-small cell lung cancer drug) 50mg / ml mother solution, and prepare five-fold diluted working s...

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Abstract

The invention relates to new application of known compounds, in particular to application of a compound VS1 in preparation of an anti-non-small cell lung cancer medicine. It is verified that the compound has an obvious inhibitory effect on non-small cell lung cancer cell lines and can be used for preparation of the anti-non-small cell lung cancer medicine. According to the application, ERBB3 is used as an action target to obtain the compound having the obvious inhibitory effect on the non-small cell lung cancer cell lines through screening, and the application aims at providing a candidate lead compound for new drug research and development of the anti-non-small cell lung cancer medicine.

Description

technical field [0001] The present invention relates to the new application of known compounds, in particular to the application of compound VS1 in the preparation of anti-non-small cell lung cancer drugs. Background technique [0002] Natural products refer to the components or their metabolites in animals, plants, insects, marine organisms and microorganisms, and many endogenous chemical components in humans and animals are collectively referred to as natural products, which mainly include proteins, polypeptides, amino acids, Nucleic acid, various enzymes, monosaccharides, oligosaccharides, polysaccharides and other naturally occurring chemical components. Natural products are widely used in drug research and development. Typical drugs that have been developed include quinine, morphine, digoxin, and vincristine. Finding bioactive components and leads from natural products to study innovative drugs is one of the effective ways recognized by scientists in new drug research ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/407A61P35/00
CPCA61K31/407
Inventor 郭榕张媛肖旭东赵勇
Owner BEIJING COMPUTING CENT
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