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A pharmaceutical composition for preventing and treating arthritis and its preparation method

A composition and arthritis technology, applied in the field of medicine, can solve problems such as poor curative effect, adverse reactions of gastrointestinal mucosa, and oral administration of drugs, etc., achieve good clinical application prospects, reduce the level of inflammatory cytokines, and safely treat effect of means

Active Publication Date: 2019-07-16
成都安普诺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a pharmaceutical composition for preventing and treating arthritis, so as to solve the problems of poor curative effect of existing drugs, oral administration of drugs, and adverse reactions caused by stimulating gastrointestinal mucosa

Method used

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  • A pharmaceutical composition for preventing and treating arthritis and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 pharmaceutical composition gel of the present invention

[0022] Prescription: Zinc sulfate 0.10g, sodium selenite 0.10g, carbomer 94010g, glycerin 75g, polysorbate 802g, triethanolamine 13.5g, distilled water added to 1000g.

[0023] Process: Mix carbomer 940 with polysorbate 80 and 300g of distilled water, and dissolve triethanolamine in 100g of distilled water, add to the above solution and stir well, then add glycerin and stir well to obtain the matrix. Dissolve zinc sulfate and sodium selenite in 250g of distilled water, add to the above matrix after fully dissolved, add water to the full amount, stir evenly, and remove air bubbles to obtain gel ZJ-1.

Embodiment 2

[0024] Embodiment 2 The preparation of pharmaceutical composition gel of the present invention

[0025] Prescription: Zinc sulfate 0.5g, sodium selenite 0.1g, carbomer 94010g, glycerin 75g, polysorbate 802g, triethanolamine 13.5g, distilled water added to 1000g.

[0026] Process: Mix carbomer 940 with polysorbate 80 and 300g of distilled water, and dissolve triethanolamine in 100g of distilled water, add to the above solution and stir well, then add glycerin and stir well to obtain the matrix. Dissolve zinc sulfate and sodium selenite in 250g of distilled water, add to the above-mentioned matrix after fully dissolved, add water to the full amount, stir evenly, and remove air bubbles to obtain gel ZJ-2.

Embodiment 3

[0027] Embodiment 3 The preparation of the pharmaceutical composition cream of the present invention

[0028] Prescription: Zinc sulfate 0.5g, sodium selenite 0.5g, white petrolatum 100g, stearyl alcohol 100g, liquid paraffin 50g, glyceryl monostearate 60g, OP emulsifier (alkylphenol polyoxyethylene ether) 10g, plain Add 20g of O, 50g of glycerin, and 20g of laurocaprazine.

[0029] Process: Take white vaseline, stearyl alcohol, glyceryl monostearate, liquid paraffin, add O, mix, heat to 80 degrees to dissolve, and obtain an oil phase. Take zinc chloride, laurocaprazine, sodium selenite, glycerin, OP emulsifier, add water 300ml, stir evenly, add the oil phase, keep warm and emulsify for 20 minutes, add water to 1000ml, and then the cream ZJ-3 is obtained.

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating arthritis, which is a preparation prepared from the following raw materials: selenium-containing inorganic compounds and zinc-containing inorganic compounds. The pharmaceutical composition can be prepared as an external preparation, which provides a faster and safer treatment method for various joint pains. Drug efficacy experiments prove that the pharmaceutical composition of the present invention can significantly reduce the level of inflammatory cytokines in the joint washing fluid of the arthritis model, and its ointment can even achieve better curative effect than Voltaren ointment, and has good clinical application prospect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating arthritis and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Arthritis generally refers to inflammatory diseases that occur in human joints and their surrounding tissues, and can be divided into dozens of types. The most common type of osteoarthritis is a degenerative joint disease, and there are other types such as rheumatoid arthritis, rheumatoid arthritis, and gouty arthritis. The etiology of this type of disease is not completely clear, and the clinical manifestations are similar. The main symptoms are joint redness, swelling, heat, pain, dysfunction and joint deformity. The commonly used anti-inflammatory drugs are mainly non-steroidal anti-inflammatory drugs, including cloth Profen, aspirin, diclofenac, etc. Among them, Voltaren ointment with diclofenac diethylamine as the main active ingredient is widely used. Howe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/30A61P19/02A61P29/00A61P19/04A61K33/04
CPCA61K9/0014A61K9/06A61K9/7061A61K33/04A61K33/30A61K47/02A61K47/06A61K47/10A61K47/14A61K47/18A61K47/22A61K47/26A61K47/32A61K47/34A61K47/38A61K47/42A61K47/44A61K2300/00A61K9/7038A61K9/7046A61K9/7069A61K47/12A61P19/02A61P19/04A61P29/00
Inventor 米军刘紫鹃
Owner 成都安普诺生物科技有限公司