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Application of extract of Schisandra chinensis in the preparation of liver regeneration medicine

A technology of Schisandra chinensis and extract, which is applied in the field of medicine, can solve problems such as the promotion of liver regeneration by extracts of Schisandra chinensis, improve inflammation infiltration and cell edema, promote liver cell proliferation, and accelerate the recovery of liver weight and function Effect

Active Publication Date: 2019-11-19
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no relevant reports on the promotion of liver regeneration after hepatectomy with Schisandra chinensis extract.

Method used

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  • Application of extract of Schisandra chinensis in the preparation of liver regeneration medicine
  • Application of extract of Schisandra chinensis in the preparation of liver regeneration medicine
  • Application of extract of Schisandra chinensis in the preparation of liver regeneration medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 Preparation of Schisandra chinensis extract

[0049] Take 100 g of Schisandra chinensis, add 8 times the amount of water to decoct for 1 hour, filter to remove the filtrate, dry the dregs and pulverize, use 8 times the amount of 70% ethanol for reflux extraction twice, 1.5 hours each time, filter, combine the filtrate, Concentrate to obtain the extract of Schisandra chinensis.

Embodiment 2

[0050] Example 2 Preparation of Schisandra chinensis extract

[0051]Take 100 g of Schisandra chinensis, add 6 times the amount of water to decoct for 0.5 h, filter to remove the filtrate, dry the dregs and crush them, reflux extraction with 6 times the amount of 70% ethanol for 1 hour each time, filter, and combine the filtrates, Concentrate to get the southern Schisandra extract extract.

Embodiment 3

[0052] Example 3 Preparation of Southern Schisandra Extract

[0053] Take 100 g of Schisandra chinensis, add 10 times the amount of water to decoct for 2 hours, filter to remove the filtrate, dry the dregs and crush them, reflux extract with 10 times the amount of 70% ethanol for 3 times, each time for 2 hours, filter, combine the filtrates, and concentrate , that is, the southern Schisandra extract extract.

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Abstract

The invention discloses application of a fructus schisandrae sphenantherae extract in preparation of a liver regeneration medicine. The fructus schisandrae sphenantherae extract is an alcohol extract of dried fruits of schisandrae sphenantherae, and the main effective ingredients of the fructus schisandrae sphenantherae extract comprise schisantherin and deoxyschizandrin. A partial hepatectomy mouse model is utilized, the fructus schisandrae sphenantherae extract is cooperatively applied, a result shows that the fructus schisandrae sphenantherae extract has the characteristics of being capable of significantly improving the quick recovering capacity of the liver-weight ratio and improving the quick proliferation capacity of liver cells, the mechanism relates to significant activation of protein expression of a related cell cycle, the manifestation is that cyclin D1 and PCNA proteins are significantly up-regulated, and meanwhile obvious improvement on liver tissue inflammatory infiltration and liver cell swelling is achieved. Experimental results show that the fructus schisandrae sphenantherae extract supplies a novel method and treatment means to liver regeneration after hepatectomy.

Description

technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to the application of Schisandra chinensis extract in the preparation of liver regeneration medicine. Background technique [0002] Hepatectomy and living donor liver transplantation are currently the most effective treatments for liver cancer and end-stage liver disease worldwide. The reason why liver resection and living donor liver transplantation are feasible in clinical applications is the unique and powerful regenerative capacity of hepatocytes. However, after a patient undergoes surgery, if the remaining liver lacks regenerative capacity, has delayed regenerative capacity, or has weak regenerative capacity, it can cause a variety of adverse syndromes, such as post-operative acute liver failure, septic infection, ascites, hemorrhage, renal failure or liver failure. encephalopathy. Among them, acute liver failure after surgery is still the main cause of post...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/79A61K36/57A61P1/16
CPCA61K36/57A61K36/79A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 毕惠嫦黄民李茜范晓梅曾雪贞李东顺
Owner SUN YAT SEN UNIV
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