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A kind of total alkaloid with anticancer effect, preparation method and application

A technology of total alkaloids and tauer is applied in the preparation of medicines that have an inhibitory effect on tumor cell growth. high yield effect

Active Publication Date: 2021-01-19
ZHEJIANG ACAD OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Tukeer is a commonly used traditional Chinese medicine in Zhejiang, and the extraction and application of its alkaloid components need to be further studied. At present, no reports have been found on the extraction and application of alkaloids in Tukeer at home and abroad.

Method used

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  • A kind of total alkaloid with anticancer effect, preparation method and application
  • A kind of total alkaloid with anticancer effect, preparation method and application
  • A kind of total alkaloid with anticancer effect, preparation method and application

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Embodiment Construction

[0020] A detailed description will be given below of specific embodiments of the present invention.

[0021] A method for preparing the total alkaloids of Tuqier. The decoction pieces of Tuqier are heated and refluxed with an acid aqueous solution to extract, centrifuged, and the precipitate is removed, and the acid aqueous solution is recovered under reduced pressure to obtain a concentrated solution, and the pH value is adjusted. Take off, collect the eluate, recover the solvent under reduced pressure, and vacuum-dry the extract to obtain the total alkaloids.

[0022] 1. Determination of the content of total alkaloids in soil

[0023] 1.1 Preparation of reference solution

[0024] Accurately weigh an appropriate amount of berberine hydrochloride reference substance, add chloroform to make a solution containing 10 μg per ml.

[0025] 1.2 Preparation of standard curve

[0026] Take the reference substance solution 1.0, 2.0, 3.0, 4.0, 5.0ml, put it in a separatory funnel, ad...

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Abstract

The invention relates to a preparation method of apios fortunei maxim total alkaloid and application of the apios fortunei maxim total alkaloid in preparation of a medicine with the effect of inhibiting tumour cell growth. The invention provides a method for extracting alkaloid from apios fortunei maxim. The method has the advantages of simplicity, easiness in learning, low cost and high yield. The invention also provides application of the apios fortunei maxim total alkaloid obtained by adopting the method in treatment of cancer and in particular relates to application in treatment of liver cancer, lung cancer, pancreatic cancer and malignant lymphoma. Cell pharmacodynamic tests show that the apios fortunei maxim total alkaloid obtained by adopting the method provided by the invention has obvious inhibitory effect on human lung adenocarcinoma A549 cells, human liver cancer HepG2 cells, human pancreatic cancer BxPC-3 cells and human malignant lymphoma Raji cells.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a method for preparing total alkaloids of Tuqier and its application in the preparation of medicines with inhibitory effect on tumor cell growth. Background technique [0002] As a commonly used traditional Chinese medicine in Zhejiang, Apios fortunei was first recorded in "Journal of Materia Medica". It is the dry tuberous root of Apios fortunei Maxim. Tudan ("Guizhou Folk Medicine"), Maru Niuzi (Jiangxi "Herbal Medicine Handbook"), Jiuzi sheep, yellow-skinned dog eggs ("Zhejiang Medicinal Flora"). Mainly distributed in Zhejiang, Jiangxi, Fujian, Taiwan, Guangdong, Guangxi, Sichuan, Guizhou and other places. The medicinal part is the dry root tuber. Sweet in taste, slightly bitter, flat in nature. "Guizhou Folk Herbal Medicine": "Dissipate accumulation, regulate qi, detoxify, and invigorate the spleen." , detoxification". Can be used for cold cough, whooping cou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P35/00
CPCA61K36/48A61K2236/333A61K2236/39A61K2236/55
Inventor 胡轶娟梁卫青徐攀浦锦宝程林张宏建周洁
Owner ZHEJIANG ACAD OF TRADITIONAL CHINESE MEDICINE
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