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Preparation process for colon drug-releasing tablets for acute colitis

A preparation process, colon technology, applied in the field of emergency medicine, can solve problems such as easy recurrence, slow recovery, long course of disease and long treatment time

Inactive Publication Date: 2016-05-04
隋光丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its long course of disease and treatment time, slow recovery and

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A kind of preparation technology of acute colon release type tablet, comprises the steps:

[0024] (1) Extract Astragalus extract: Take 200g of Radix Astragali, put it into a microwave extractor, add 2800mL of 70% ethanol for the first two times, extract for 25min, add 2800mL of purified water for the third time, extract for 35min, and extract the solution for the first two times until it is rotated Concentrate to 1g.mL in an evaporator -1 , add the third extract and continue to concentrate to 0.5g.mL -1 , to obtain a concentrated solution;

[0025] (2) Purification: the concentrate is placed in a high-speed refrigerated centrifuge for centrifugation to obtain a purified centrate;

[0026] (3) Drying: add 44.5 g of microcrystalline cellulose to the purified centrifugal liquid, stir evenly, and dry in a vacuum oven for 12 hours to obtain a dried drug body;

[0027] (4) Pulverization and disintegration: Take out the dried drug body and pulverize it, pass through a 100-...

Embodiment 2

[0037] A kind of preparation technology of acute colon release type tablet, comprises the steps:

[0038] (1) Extraction of Astragalus extract: Take 210g of Astragalus medicinal material, put it into a microwave extractor, add 2900mL of 70% ethanol for the first two times, extract for 27min, add 2900mL of purified water for the third time, extract for 37min, and extract the solution for the first two times until it is rotated Concentrate to 1.5g.mL in an evaporator -1 , add the third extract and continue to concentrate to 0.6g.mL -1 , to obtain a concentrated solution;

[0039] (2) Purification: the concentrate is placed in a high-speed refrigerated centrifuge for centrifugation to obtain a purified centrate;

[0040] (3) Drying: add 45 g of microcrystalline cellulose to the purified centrifuge, stir evenly, and dry in a vacuum oven for 14 hours to obtain a dried drug body;

[0041] (4) Pulverization and disintegration: take out the dried drug body and pulverize it, pass th...

Embodiment 3

[0051] A kind of preparation technology of acute colon release type tablet, comprises the steps:

[0052] (1) Extraction of Astragalus extract: Take 220g of Astragalus medicinal material, put it into a microwave extractor, add 3000mL of 70% ethanol for the first two times, extract for 30min, add 3000mL of purified water for the third time, extract for 40min, and extract the solution for the first two times until it is rotated Concentrate to 2g.mL in an evaporator -1 , add the third extract and continue to concentrate to 0.7g.mL -1 , to obtain a concentrated solution;

[0053] (2) Purification: the concentrate is placed in a high-speed refrigerated centrifuge for centrifugation to obtain a purified centrate;

[0054] (3) Drying: add 44.5 g of microcrystalline cellulose to the purified centrifugal liquid, stir evenly, and dry in a vacuum oven for 15 hours to obtain a dried drug body;

[0055] (4) Pulverization and disintegration: take out the dried drug body and pulverize it,...

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PUM

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Abstract

The invention relates to the technical field of emergency medical treatment, in particular to a preparation process for colon drug-releasing tablets for acute colitis. The preparation process comprises the following steps: (1) extraction of an astragalus extracting solution; (2) purification; (3) drying; (4) crushing and disintegration; (5) tablet forming; (6) tablet coating; (7) quality index detection. According to the preparation process, astragalus with the effects of clearing heat, drying dampness and purging fire for removing toxins is prepared into the colon drug-releasing tablets to directly reach focuses and alleviate symptoms, and the two are combined to fulfill the aims of treating both symptoms and root causes, improving the medication compliance of a patient and clean intestinal canals and prevent the patient from mediation inconvenience and physical and mental damage caused by a combined oral administration and coloclysis treatment method.

Description

technical field [0001] The invention relates to the technical field of emergency medical treatment, in particular to a preparation process of an acute colon drug-release tablet. Background technique [0002] The colon continues with the cecum in the right iliac fossa and joins the rectum at the level of the third sacral vertebra. The colon is divided into 4 parts, the ascending colon, the transverse colon, the descending colon and the sigmoid colon, most of which are fixed on the posterior abdominal wall. The diameter of the colon is 6 cm from its origin and gradually decreases to 2.5 cm at the end of the sigmoid colon, which is the narrowest part of the colon lumen. [0003] The mucosa of the intestinal wall was stained purple with naked eyes, and the submucosa, muscular layer and adventitia were in turn outward. The protrusion of the mucosa and part of the submucosa into the intestinal lumen is the cross-section of semicircular folds, and the local expansion of the muscu...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/32A61P1/04
CPCA61K36/481A61K9/2054A61K9/2846A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 隋光丽李娜焦克德陈丽媛王芳窦美芳朱苗苗尹喜玲
Owner 隋光丽