Method for preparing fluorescence silk fibers from small soluble organic molecule

Abstract

The invention relates to a method for preparing fluorescence silk fibers from a small soluble organic molecule. The small soluble organic molecule 5-oxo-3,5-dihydro-2H-thiazole [3,2-a] pyridine-7-carboxylic acid (TPCA) or 5-oxo-3,5-dihydro-2H-thiazole [3,2-a] pyridine-3,7-dicarboxylic acid (TPDCA) is used as a fluorescence source, the silk fibers are soaked in a fluorescence source water solution after being degummed, TPCA is combined with and adsorbed to silk fibroin macromolecules at the room temperature or the high temperature of 85 DEG C by adjusting the system pH value, and TPCA and silk fibroin macromolecule chains are fixedly combined through the fixation action of didodecyl dimethyl ammonium chloride (DDTAC) to prepare the small organic molecule fluorescence silk fibers which are nontoxic and good in biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a method for preparing fluorescent silk fibers by utilizing small soluble organic molecules. Background technique [0002] Silk fiber has great softness, high water absorption and excellent hand feeling. It was first used in ancient Chinese textiles and has a history of more than 2,000 years of application and production in the field of traditional textile and apparel. Silk fiber is a continuous long fiber formed by the coagulation of the silk liquid secreted by cooked silkworms when they cocoon. Its components are composed of silk fibroin in the inner layer and sericin in the outer layer. Silk fibroin is a protein macromolecule with a high degree of crystallinity and orientation, which mainly bears the mechanical and physical properties. Sericin is mainly composed of polysaccharides and pectin, which is the protective layer of silk fibroin. Silk itself is a natura...

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Problems solved by technology

[0004] However, combining the above two categories of methods has its own defects and limitations.

Quantum dot luminescent silk, although the type and particle size of quantum dots can be controlled to regulate different fluorescent colors, but quantum dots are toxic and cannot be used as biological materials, which limits the biological application of fluorescent silk

In addition, the relevant reports of quantum dot fluorescent silk did not mention the problem of fluorescence fastness, and the problem of water resistance is questionable

Although the feeding method and genetic engineering can directly spit out fluorescent silk from silk glands of silkworms, the absorption of fluorescent dyes in the feeding method is limited, and the cultivation period is long. In addition, the fluorescence fastness to washing is also questionable.

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