The invention discloses anti-radiation lithium-aluminum-silicate system low-expansion window glass and belongs to lithium-aluminum-silicate system glass ceramics. The glass is prepared from, by mass, 2.5-8.5% of Li2O, 16.2-26% of Al2O3, 40-71.8% of SiO2, 0.8-4.6% of TiO2, 0.6-3.7% of ZrO2, 1.3-7% of P2O5, 0.7-3.1% of F-, 0.7-3.9% of CeO2, 1.8-6.9% of B2O3, 0.5-3.5% of Na2O, 0.4-3% of K2O, 0.6-4.5% of MgO, 0.2-5.2% of CaO, 0-3.7% of SrO, 0-3% of BaO, 1.9-8.2% of ZnO, 0-1.2% of Cl- and 0-1.3% of SO42+. The invention further provides a machining process of the anti-radiation lithium-aluminum-silicate system low-expansion window glass. The window glass has high transmission, high strength, good in cold-heat impact resistance, small expansion coefficients and anti-radiation stability, can be widely applied in the aerospace field such as a transparent observation window of a spacecraft.