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Preparation and application of total flavonoids from lotus seed heart for preventing and treating type ii diabetes

A technology of total flavonoids of lotus seed heart and lotus seed heart, applied in the auxiliary treatment of type II diabetes, the field of preparation of total flavonoids of lotus seed heart, can solve the problems of adverse reactions of the body, extraction of lotus seed heart flavonoids has not been seen, and no radical cure has been found , to achieve the effect of stable and reliable process, prevention and auxiliary treatment of type II diabetes, and reduction of toxic and side effects

Active Publication Date: 2020-03-17
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex pathogenesis of diabetes, humans have not yet found a cure, and patients need life-long treatment
At present, the drugs used in the clinical treatment of diabetes are mainly western medicines. Although they have the characteristics of obvious effects and short duration of action, they have certain side effects, which are easy to cause adverse reactions in the body, and long-term large-dose use will damage human body functions.
At present, there is no technology for extracting flavonoids from lotus seed heart by using microwave-ultrasonic synergy, and no research on the hypoglycemic activity of total flavonoids from lotus seed heart

Method used

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  • Preparation and application of total flavonoids from lotus seed heart for preventing and treating type ii diabetes
  • Preparation and application of total flavonoids from lotus seed heart for preventing and treating type ii diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A preparation method of lotus seed heart total flavonoids for preventing and treating type II diabetes comprises the following steps:

[0018] 1) Weigh the fresh lotus seed heart, wash away impurities, dry at 40°C to constant weight, and ultrafinely pulverize to a fineness of 10 μm;

[0019] 2) Add ethanol solution with a mass concentration of 70% to the lotus seed heart powder prepared in step 1) at a mass volume ratio of 1: 20 (g / mL), and extract with microwave-ultrasonic synergy for 15 min at a microwave power of 300 W. The power is 200 W, the ultrasonic program is to run for 1s and then stop for 0~2s, and then circulate like this, and then filter; repeat the extraction of the filter residue twice according to the above steps, combine the filtrate, centrifuge at 3000 r / min for 20 min, and take the supernatant , concentrated at 50°C to an extract, and freeze-dried to obtain the crude total flavonoids of lotus seed heart;

[0020] 3) Put the crude total flavonoids of ...

Embodiment 2

[0022] A preparation method of lotus seed heart total flavonoids for preventing and treating type II diabetes comprises the following steps:

[0023] 1) Weigh fresh lotus seeds, wash away impurities, dry at 45°C to constant weight, and ultrafinely pulverize to a fineness of 10 μm;

[0024] 2) Add ethanol solution with a mass concentration of 75% to the lotus seed powder prepared in step 1) at a mass volume ratio of 1:30 (g / mL), and extract with microwave-ultrasonic synergy for 10 min at a microwave power of 350 W. The power is 300 W, the ultrasonic program is to run for 1s and stop for 0~2s, and then circulate like this, and then filter; repeat the extraction of the filter residue twice according to the above steps, combine the filtrate, centrifuge at 3500 r / min for 15 min, and take the supernatant , concentrated at 60°C to an extract, freeze-dried to obtain the crude total flavonoids of lotus seed heart;

[0025] 3) Put the crude total flavonoids of lotus seed heart prepared...

Embodiment 3

[0027] A preparation method of lotus seed heart total flavonoids for preventing and treating type II diabetes comprises the following steps:

[0028] 1) Weigh the fresh lotus seed heart, wash away impurities, dry at 50°C to constant weight, and ultrafinely pulverize to a fineness of 15 μm;

[0029] 2) Add an ethanol solution with a mass concentration of 80% to the lotus seed powder prepared in step 1) at a mass volume ratio of 1:40 (g / mL), and extract with microwave-ultrasonic synergy for 5 min at a microwave power of 400 W. The power is 400 W, the ultrasonic program is to run for 1s and stop for 0~2s, and then circulate like this, and then filter; repeat the extraction of the filter residue 3 times according to the above steps, combine the filtrate, centrifuge at 4000 r / min for 10 min, and take the supernatant , concentrated at 65°C to an extract, freeze-dried to obtain the crude total flavonoids of lotus seed heart;

[0030] 3) Put the crude total flavonoids of lotus seed h...

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Abstract

The invention discloses a preparation method of lotus plumule total flavones and application thereof to adjuvant therapy of II-type diabetes and belongs to the technical field of medicine and health care products. Lotus plumule total flavones is obtained by combining a microwave-ultrasonic collaborative auxiliary extraction method and a supercritical fluid extraction method, the extraction rate can reach 2.66%, and after the obtained lotus plumule total flavones is mixed into an auxiliary material, the dosage form acceptable to pharmacy can be obtained. It is testified by animal pharmacodynamics that the lotus plumule total flavones can lower the blood glucose of II-type diabetes model mice which are diseased by streptozotocin, the glucose-lowering rate can reach 43.02%, the efficacy for improving insulin resistance is achieved, fasting blood sugar value of the II-type diabetes can be lowered, and the II-type diabetes is prevented and treated in an assisted mode.

Description

technical field [0001] The invention belongs to the technical field of medicine and health products, and in particular relates to a preparation method of total flavonoids from lotus seed heart and its application in auxiliary treatment of type II diabetes. Background technique [0002] Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia caused by defects in insulin secretion and / or its biological function, and its threat to human health is second only to cardiovascular and cerebrovascular diseases and tumors. Diabetes is no longer just a disease of the rich in industrialized developed countries. Developing countries in Asia, including China, have become the hardest hit areas for diabetes. The number of people with diabetes in China accounts for 1 / 3 of the global population, and the urban incidence rate is 11.4%. The world's first. Due to the complex pathogenesis of diabetes, humans have not yet found a cure, and patients need life-long treatment....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/62A61P3/10A23L33/105
CPCA23V2002/00A61K36/62A61K2236/33A61K2236/37A61K2236/39A61K2236/51A61K2236/53A23V2200/328A23V2250/21
Inventor 赵超刘斌李秋哲杨成凤陈玉青陈明军
Owner FUJIAN AGRI & FORESTRY UNIV