Medical micro-porous biological hemostatic material and preparation method thereof

A hemostatic material and biological technology, applied in the field of biomedical hemostatic materials, can solve the problems of insufficient hemostasis speed, limited wide application, unsatisfactory hemostatic effect, etc., and achieves good hemostasis effect, avoids agglomeration, and is easy to swell.

Inactive Publication Date: 2016-05-25
广西达庆生物科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the hemostatic effect of these current technologies is not ideal, and the hemostatic speed is not fast enough, which limits its wide application in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A medical microporous biological hemostatic material is composed of the following raw materials in weight percentage:

[0042] Collagen 20%

[0043] Hyaluronic Acid 40%

[0044] Puffball spore powder 40%.

[0045] The hyaluronic acid is a pharmaceutical grade powder with an average molecular weight of 500 Daltons.

[0046] The collagen is medical grade collagen with an average molecular weight of 1000 Daltons.

[0047] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 110 degrees Celsius, crushing and passing through a sieve of more than 100 mesh.

[0048] The above collagen, hyaluronic acid and puffball spore powder are mixed to obtain a medical microporous biological hemostatic material.

Embodiment 2

[0050] A medical microporous biological hemostatic material is composed of the following raw materials in weight percentage:

[0051] Collagen 40%

[0052] Hyaluronic Acid 20%

[0053] Puffball spore powder 40%.

[0054] The hyaluronic acid is a pharmaceutical grade powder with an average molecular weight of 1000 Daltons.

[0055] The collagen is medical grade collagen with an average molecular weight of 500 Daltons.

[0056] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 120 degrees Celsius, and passing through a sieve with a mesh size of 100 or more after crushing.

[0057] The collagen is nanoscale collagen.

[0058] A medical microporous biological hemostatic material is obtained by mixing collagen, hyaluronic acid and puffball spore powder.

[0059] Collagen, hyaluronic acid, and puffball spore powder are mixed evenly and then ultrason...

Embodiment 3

[0061] A medical microporous biological hemostatic material is composed of the following raw materials in weight percentage:

[0062] Collagen 40%

[0063] Hyaluronic Acid 40%

[0064] Puffball spore powder 20%.

[0065] The hyaluronic acid is a pharmaceutical grade powder with an average molecular weight of 2000 Daltons.

[0066] The collagen is medical grade collagen with an average molecular weight of 900 Daltons.

[0067] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 130 degrees Celsius, and passing through a sieve with a mesh size of 100 or more after crushing.

[0068] The collagen is nanoscale collagen.

[0069] A medical microporous biological hemostatic material is obtained by mixing collagen, hyaluronic acid and puffball spore powder.

[0070] Collagen, hyaluronic acid, and puffball spore powder are mixed evenly and then ultrason...

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Abstract

The invention relates to a bio-medicine hemostatic material, in particular to a medical micro-porous biological hemostatic material and a preparation method thereof. The medical micro-porous biological hemostatic material is composed of collagen, hyaluronic acid and puffball spore powder. Collagen can be rapidly combined with hemoglobin in blood to form hemostatic clots, and in addition, after collagen and wounds are tightly combined, collagen can permeate into regenerated tissue and serve as a support for cell growth; hyaluronic acid can instantly absorb water in blood to form hydrogel, and therefore exudation is blocked; the three substances form physical barriers, isolate wounds, and achieve the effects of adhesion prevention and instant hemostasis. The medical micro-porous biological hemostatic material is used for hemostasis of exudation of various wounds and fresh tissue wound surfaces, small vessel bleeding and bleeding regions, and prevents adhesion.

Description

technical field [0001] The invention relates to the technical field of biomedical hemostatic materials, in particular to a medical microporous biological hemostatic material and a preparation method thereof. Background technique [0002] Hemostasis is an important link in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. The normal hemostasis mechanism mainly includes three aspects: the contraction of small blood vessels, the activation of platelets and the activation of the coagulation system. Among them, the contraction of small blood vessels is the earliest response to hemostasis after trauma. After the blood vessels are damaged, the smooth muscles of the blood vessels constrict the blood vessels and slow down the blood flow through axon reflex, which is beneficial to blood coagulation and hemostasis. Platelets have the physiological function of adhering to the surface of wou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/10A61L24/00
CPCA61L24/08A61L24/0005A61L24/001A61L24/0015A61L24/102A61L2300/30A61L2300/404A61L2400/04
Inventor 梁奕福
Owner 广西达庆生物科技有限公司
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