Application of pullulan and its derivatives in the preparation of sustained and controlled release drug granules

Abstract

The invention discloses application of pullulan polysaccharide and a derivative thereof to the preparation of a slow and controlled release drug particle. As slow and controlled release agents, the pullulan polysaccharide and the derivative thereof are used for preparing a pulmonary delivered and inhaled drug particle with slow and controlled release characteristics; the pullulan polysaccharide and the derivative thereof as well as a pharmacological active ingredient of a pulmonary delivered and inhaled drug are made into a pulmonary delivered and inhaled drug particle of which the particle size is smaller than 10 [mu]m and which can be being inhaled into pulmonary alveoli. In the invention, under the existence of the pullulan polysaccharide and the derivative, the pharmacological active ingredient capable of being inhaled into the particle under the sub-micro scale still has obvious slow and controlled release characteristics and is obviously superior to other accessories; therefore, after the pharmacological active ingredient is inhaled into a lung, under the action of the pullulan polysaccharide or the derivative thereof, the slow and controlled release is expected to be realized, so that the drug action time is prolonged, the therapeutic effect is improved, and meanwhile, the frequency of drug administration is reduced; as for patients suffering from lung function impairment, the significance is greater.

Description

technical field [0001] The present invention relates to the application of a polysaccharide, in particular to the application of a pullulan polysaccharide and its derivatives, and further relates to the application of a pullulan polysaccharide and its derivatives in the preparation of inhalable drug particles with slow-controlled release characteristics application. Background technique [0002] Inhaled drugs are the method of choice for the treatment of localized diseases such as asthma and chronic obstructive pneumonia. In recent years, it has developed into a new drug route for the treatment of systemic diseases such as diabetes and cardiovascular diseases. Traditional inhaled drugs are generally absorbed very quickly in the lungs, which will bring some disadvantages, including high peak concentration of drugs, which may cause relatively large toxic and side effects; in addition, repeated inhalation of drugs is required to produce continuous therapeutic effects, This is...

AI Technical Summary

Problems solved by technology

When these excipients are prepared into traditional preparations such as tablets and capsules, they can significantly prolong the release time of the active ingredient of the drug, but when they are prepared into submicron-sized particles, their effect on the slow release of the drug is not obvious

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