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A kind of domperidone dry suspension for children and preparation method thereof

A technology of domperidone and dry suspension, applied in the field of medicine, can solve the problems of low drug dissolution, drug bitterness and the like

Active Publication Date: 2018-07-06
SHANDONG SBOND PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through innovative selection of excipients, optimized ratio of excipients and innovative preparation process, the problems of low drug dissolution and bitterness of drugs have been successfully solved

Method used

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  • A kind of domperidone dry suspension for children and preparation method thereof
  • A kind of domperidone dry suspension for children and preparation method thereof
  • A kind of domperidone dry suspension for children and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0196] Embodiment 1, a kind of preparation method of domperidone dry suspension for children

[0197] 1. A dry suspension of domperidone for children is made by parts by mass of the following raw materials:

[0198]

[0199] 2. The preparation method is as follows:

[0200] (1) Domperidone is pulverized and passed through a 150-mesh sieve to obtain an average particle size of 28-32 μm, which is set aside;

[0201] (2) Pulverize the white sugar and hydroxypropyl cellulose of formula quantity, cross 110 mesh sieves, set aside;

[0202] (3) Domperidone and mannitol that take formula quantity are dissolved in deionized water and are mixed with a mixed solution of 55% (W / W), and put into a freeze-drying box; -40°C~-50°C, when the temperature of the mixed solution drops to -30°C~-40°C, pre-freeze and keep warm for about 2~3 hours; start vacuuming, then gradually increase the temperature to -10°C~-15°C, and slowly heat up And vacuum-dry for 18 hours; raise the shelf temperature...

Embodiment 2

[0208] Embodiment 2, a kind of preparation method of domperidone dry suspension for children

[0209] 1. A dry suspension of domperidone for children is made by parts by mass of the following raw materials:

[0210]

[0211] 2. The preparation method is as follows:

[0212] (1) Domperidone is pulverized and passed through a 160-mesh sieve to obtain particles with an average particle diameter of 21-24 μm for subsequent use;

[0213] (2) Pulverize the white sugar and hydroxypropyl cellulose of formula quantity, cross 120 mesh sieves, set aside;

[0214] (3) Domperidone and mannitol that take formula quantity are dissolved in deionized water and are mixed with 60% (W / W) mixed solution, put into freeze-drying box; -40℃~-50℃, when the temperature of the mixed solution drops to -30℃~-40℃, pre-freeze and keep warm for 2-3 hours; start vacuuming, then gradually increase the temperature to -10℃~-15℃, slowly heat up and Vacuum dry for 20 hours; raise the shelf temperature again to 3...

Embodiment 3

[0220] Embodiment 3, a kind of preparation method of domperidone dry suspension for children

[0221] 1. A dry suspension of domperidone for children is made by parts by mass of the following raw materials:

[0222]

[0223] 2. The preparation method is as follows:

[0224] (1) Domperidone is pulverized and passed through a 155-mesh sieve to obtain particles with an average particle diameter of 24-28 μm for subsequent use;

[0225] (2) Pulverize the white sugar and hydroxypropyl cellulose of formula quantity, cross 115 mesh sieves, set aside;

[0226] (3) Domperidone and mannitol that take formula quantity are dissolved in deionized water and are mixed with 50% (W / W) mixed solution, put into freeze-drying box; -40°C~-50°C, when the temperature of the mixed solution drops to -30°C~-40°C, pre-freeze and keep warm for 2~3 hours; start vacuuming, then gradually increase the temperature to -10°C~-15°C, slowly heat up and Vacuum dry for 15-20 hours; raise the shelf temperature...

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Abstract

The invention discloses a children domperidone dry suspension and a preparation method of the children domperidone dry suspension. The dry suspension is prepared from the following raw materials in parts by mass: 10 to 30 parts of domperidone, 10 to 30 parts of fatty glyceride, 5 to 10 parts of Tween 80, 900 to 2700 parts of white sugar, 10 to 30 parts of hydroxy propyl cellulose, 10 to 30 parts of mannitol, 0.02 to 0.05 part of essence, 0.2 to 0.5 part of magnesium stearate and 0.2 to 0.5 part of micro-powder silica gel. The dry suspension is prepared by taking the domperidone as a medicine effective component through innovative auxiliary material selection, an optimized auxiliary material ratio and an innovative preparation process. According to the domperidone dry suspension prepared by the invention, the problems that the dissolution rate of the medicine is low, the medicine has a bitter and astringent taste and the like are successfully solved; the children domperidone dry suspension has a good effect on functional dyspepsia of children.

Description

technical field [0001] The invention relates to a drug for gastrointestinal motility, in particular to a dry suspension of domperidone for children and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Domperidone is a synthetic benzoimidazole derivative, it is a dopamine receptor antagonist with anti-emetic effect, and it is difficult to enter the brain through the blood-brain barrier. Domperidone acts on the chemoreceptor trigger area outside the blood-brain barrier, so it hardly acts on the central nervous system; domperidone selectively blocks dopamine 2 (DA2) receptors and mainly acts on the peripheral nervous system. Since DA2 receptors are also the main receptors in the gastrointestinal tract, DA2 receptor antagonists reduce dopamine-mediated relaxation of gastric smooth muscle. In the gastrointestinal tract, domperidone acts as a prokinetic agent, increasing the motility of the digestive tract. [0003] Anorex...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/26A61K47/14A61K47/38A61K31/454A61P1/14
CPCA61K9/1617A61K9/1623A61K9/1652A61K31/454
Inventor 乔敏袁武杰
Owner SHANDONG SBOND PHARMA
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