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Photosensitive antibacterial hydrogel and preparation method thereof

A photosensitive antibacterial and hydrogel technology, applied in the field of biomedical material preparation, can solve the problems of complex components, poor stability of tissue selective photodynamic damage intensity, etc., to achieve improved stability, wide biocompatibility, and increased lifespan Effect

Active Publication Date: 2016-06-15
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The second-generation photosensitizer partially overcomes the shortcomings of the first-generation photosensitizer's complex components and poor stability to tissue selectivity and photodynamic damage intensity

Method used

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  • Photosensitive antibacterial hydrogel and preparation method thereof
  • Photosensitive antibacterial hydrogel and preparation method thereof

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Embodiment 1

[0038] A kind of photosensitive antibacterial hydrogel, described hydrogel is made through the following steps:

[0039] (1) First, at 20° C., montmorillonite and methylene blue were dissolved in deionized water respectively, first stirred for 15 minutes, then ultrasonically treated for 10 minutes, and the above process was repeated once to form an aqueous solution of montmorillonite and an aqueous solution of methylene blue; The mass concentration of the montmorillonite aqueous solution is 1%; the concentration of the methylene blue aqueous solution is 10000 μmol / L.

[0040] (2) Then, 5 mL of montmorillonite aqueous solution was mixed with 1 mL of methylene blue aqueous solution, and stirred at 500 rpm for 5 min to obtain a montmorillonite-modified methylene blue aqueous solution;

[0041] (3) Then, polyvinyl alcohol-styrene pyridinium salt (PVA-SbQ) (the content of styrene pyridinium salt is 4.1mol%) was dissolved in deionized water to form an aqueous solution with a mass co...

Embodiment 2

[0046] A kind of photosensitive antibacterial hydrogel, described hydrogel is made through the following steps:

[0047] (1) First, at 30°C, montmorillonite and meso-tetrakis(N-methyl-4-pyridine)porphine zinc tetrachloride were dissolved in deionized water respectively, stirred for 20 minutes, and then ultrasonically treated for 20 minutes. Minutes, repeat above-mentioned process once, form montmorillonite aqueous solution, meso-tetrakis (N-methyl-4-pyridine) porphine zinc tetrachloride aqueous solution; The mass concentration of described montmorillonite aqueous solution is 0.1%; The meso - The concentration of the tetrakis(N-methyl-4-pyridine)porphine zinc tetrachloride aqueous solution is 100 μmol / L.

[0048] (2) Then, 5 mL of montmorillonite aqueous solution was mixed with 1 mL of meso-tetrakis(N-methyl-4-pyridine) porphine zinc tetrachloride aqueous solution, and stirred for 6 min at 500 rpm to obtain montmorillonite-modified meso- Four (N-methyl-4-pyridine) porphine zin...

Embodiment 3

[0054] A kind of photosensitive antibacterial hydrogel, described hydrogel is made through the following steps:

[0055] (1) First, at 20°C, montmorillonite and meso-tetrakis(1-methylpyridin-4-yl)porphine p-toluenesulfonate were dissolved in deionized water respectively, first stirred for 25 minutes, and then Ultrasonic treatment 30 minutes, repeat above-mentioned process twice, form montmorillonite aqueous solution, meso-tetrakis (1-methylpyridin-4-yl) porphine p-toluenesulfonate aqueous solution; The mass concentration of described montmorillonite aqueous solution 0.5%; the concentration of the meso-tetrakis(1-methylpyridin-4-yl) porphine p-toluenesulfonate aqueous solution is 500 μmol / L.

[0056] (2) Then, mix 5 mL of montmorillonite aqueous solution with 1 mL of meso-tetrakis(1-methylpyridin-4-yl) porphine p-toluenesulfonate aqueous solution, and stir for 8 min at 500 rpm to obtain montmorillonite-modified Meso-tetra(1-methylpyridin-4-yl) porphine p-toluenesulfonate aqueo...

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Abstract

The invention discloses photosensitive antibacterial hydrogel and a preparation method thereof.The method comprises the following steps that 1, imvite and a photosensitizer are dissolved into deionized water respectively to form an imvite water solution and a photosensitizer water solution; 2, the imvite water solution and the photosensitizer water solution are mixed to obtain a photosensitive water solution modified by imvite; 3, polyvinyl alcohol-aminostyrylpyridinium salt is dissolved into deionized water to form a water solution which is mixed with the photosensitive water solution modified by imvite obtained in the step 2; 4, finally, the mixed solution obtained in the step 3 is placed under an ultraviolet lamp to be irradiated, so that the photosensitive antibacterial hydrogel is obtained.The photosensitive antibacterial hydrogel can generate phototoxic singlet oxygen under visual light irradiation, the singlet oxygen can efficiently kill viruses, bacteria and fungi, and no drug resistance is generated.

Description

technical field [0001] The invention relates to the technical field of preparation of biomedical materials, in particular to a photosensitive antibacterial hydrogel prepared from montmorillonite, a photosensitizer and polyvinyl alcohol-styrene pyridinium salt as raw materials. Background technique [0002] Hydrogel is one of the new polymer materials with a three-dimensional space network structure formed by physical or chemical cross-linking with water as the dispersion medium. It cannot be dissolved in water, but it can swell in water and absorb a large amount of water. Moisture, has a strong water storage capacity, and has good biocompatibility and chemical and physical properties. [0003] Photodynamic therapy Photodynamic therapy (Photodynamic Therapy, PDT) is a new physical and chemical treatment technology developed in recent years. The latter forms singlet oxygen, free radicals or free radical ions, etc., which act on target cells and cause cell death or apoptosis. ...

Claims

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Application Information

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IPC IPC(8): C08F293/00C08F2/50C08F2/44C08K9/04C08K3/34
CPCC08F2/44C08F2/50C08F293/005C08K3/346C08K9/04
Inventor 王清清魏取福董建成张权代雅轩
Owner JIANGNAN UNIV
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