Composition containing flavonoids from lotus seed heart and its application in reducing blood lipid

A kind of heart flavonoid and compound technology, applied in the application of lowering blood lipids, the field of compositions containing lotus seed heart flavonoids can solve the problems of side effects, adverse reactions and the like, and achieve the effects of reducing toxic side effects and assisting blood lipid lowering

Active Publication Date: 2019-11-19
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the medicines used for the clinical treatment of hyperlipidemia are mainly western medicines. Although their effects are obvious, they have side effects and easily cause adverse reactions in the body.

Method used

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  • Composition containing flavonoids from lotus seed heart and its application in reducing blood lipid
  • Composition containing flavonoids from lotus seed heart and its application in reducing blood lipid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A composition containing lotus seed flavonoids, the preparation method of which comprises the following steps:

[0026] 1) Weigh fresh lotus seed heart, Ganoderma lucidum and Phellinus japonica, wash away impurities, dry at 40°C to constant weight, and then ultrafinely pulverize them to a fineness of 0.1 μm to obtain superfine powder of lotus seed heart, Ganoderma lucidum and Phellinus superfine powder. Micropowder;

[0027] 2) Add an ethanol solution with a mass concentration of 80% to the superfine powder of lotus seed heart prepared in step 1) at a weight-to-volume ratio of 1:20 (g / mL), and extract with microwave-ultrasonic synergy for 10 minutes. The microwave power is 300 W, and ultrasonic The power is 200 W, the ultrasonic program is to run for 1s and then stop for 0~2s, and then circulate like this, and then filter; repeat the extraction of the filter residue twice according to the above steps, combine the filtrate, centrifuge at 3000 r / min for 20 min, and take t...

Embodiment 2

[0034] A composition containing lotus seed flavonoids, the preparation method of which comprises the following steps:

[0035] 1) Weigh fresh lotus seed heart, Ganoderma lucidum and Phellinus japonica, wash away impurities, dry at 45°C to constant weight, and then ultrafinely pulverize them to a fineness of 1.0 μm to obtain ultrafine powder of lotus seed heart, Ganoderma lucidum and Phellinus superfine powder. Micropowder;

[0036] 2) Add an ethanol solution with a mass concentration of 75% to the superfine powder of lotus seed heart prepared in step 1) at a weight-to-volume ratio of 1:30 (g / mL), and extract with microwave-ultrasonic synergy for 15 minutes at a microwave power of 350 W. The power is 300 W, the ultrasonic program is to run for 1s and stop for 0~2s, and then circulate like this, and then filter; repeat the extraction of the filter residue twice according to the above steps, combine the filtrate, centrifuge at 3500 r / min for 15 min, and take the supernatant , co...

Embodiment 3

[0043] A composition containing lotus seed flavonoids, the preparation method of which comprises the following steps:

[0044] 1) Weigh fresh lotus seed heart, Ganoderma lucidum and Phellinus japonica, wash away impurities, dry at 40-50°C to constant weight, and ultrafinely pulverize them to a fineness of 1.5 μm to obtain superfine powder of lotus seed heart, superfine powder of Ganoderma lucidum and Phellinus mulberry yellow superfine powder;

[0045] 2) Add ethanol solution with a mass concentration of 70% to the superfine powder of lotus seed heart prepared in step 1) at a weight-to-volume ratio of 1:40 (g / mL), and extract with microwave-ultrasonic synergy for 20 minutes. The microwave power is 400 W, and ultrasonic The power is 400 W, the ultrasonic program is to run for 1s and stop for 0~2s, and then circulate like this, and then filter; repeat the extraction of the filter residue 3 times according to the above steps, combine the filtrate, centrifuge at 4000 r / min for 10 ...

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Abstract

The invention belongs to the technical field of medical healthcare products and discloses a plumula nelumbinis flavonoid compound containing composition and application thereof to blood lipid reduction. The plumula nelumbinis flavonoid compound containing composition is prepared by steps: adopting a microwave-ultrasonic assisted extraction method for obtaining total plumula nelumbinis flavonoids; performing chromatographic purification through polyamide resin columns to obtain a plumula nelumbinis flavonoid compound, wherein the rutin content is 77.8mg / g; compounding the plumula nelumbinis flavonoid compound with prepared ganoderma lucidum polysaccharides, phellinus linteus polysaccharides and tea polyphenol to obtain the composition. According to animal pharmacodynamics, the plumula nelumbinis flavonoid compound containing composition is capable of evidently reducing triglyceride and total cholesterol of high-fat animals and can be made into common dosage forms such as capsules, tablets, pills, powder, oral liquid and granules to be used with clinical treatment medicines, and a remarkable auxiliary blood lipid reduction function can be realized.

Description

technical field [0001] The invention belongs to the technical field of medical and health products, and in particular relates to a composition containing flavonoids from lotus seed heart and its application in reducing blood fat. Background technique [0002] Hyperlipidemia mainly refers to the symptoms of elevated plasma concentration of one or more lipids caused by abnormal fat metabolism or transport. Due to the different types of hyperlipidemia, lipid-lowering drugs are divided into two categories: lowering triglycerides and lowering cholesterol according to their pharmacological effects. [0003] With the gradual improvement of living standards, the incidence of hyperlipidemia is increasing year by year. Hyperlipidemia is one of the important causes of coronary heart disease, arteriosclerosis and myocardial infarction. It will also aggravate diabetes, hypertension, pancreatitis, Progression of diseases such as liver cirrhosis. The medicines currently used for the clin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K36/82A61P3/06A23L33/00A23L33/105
CPCA23V2002/00A61K31/715A61K36/07A61K36/074A61K36/62A61K36/82A61K2236/15A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2236/55A61K2300/00A23V2200/3262A23V2250/2116A23V2250/208A23V2250/2132A23V2300/48
Inventor 赵超李秋哲刘斌杨成凤陈玉青陈明军
Owner FUJIAN AGRI & FORESTRY UNIV
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