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A preparation method of polymer polyester composite material with adjustable biodegradation rate

A technology of polymer polyester and composite materials, applied in the field of preparation of polymer polyester composite materials, can solve the problems of poor strength, slow degradation rate, stimulation effect, etc., to improve biocompatibility and adjustable biodegradation rate , the effect of easy modification and functionalization

Active Publication Date: 2017-06-13
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] CN10313533A provides a kind of polylactic acid copolymer and its preparation method, modified polylactic acid, the polylactic acid copolymer prepared by this method is more stable than the existing polylactic acid modified with small molecules, but in the process of degradation It will produce carboxylic acids containing aromatic rings such as terephthalic acid, which has a certain stimulating effect on organisms
However, its degradation rate is slow and its strength is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Synthesis of polyfumaric acid glycol polyester prepolymer

[0039] Add fumaric acid and 1,4-propanediol (molar ratio: 1:1.05) into a three-necked flask, pass through nitrogen for 30 minutes to remove the air in the system, connect a nitrogen air bag, and stop the ventilation after the air bag is inflated. Stir and react at 180°C for 1 hour; then add a transesterification catalyst, 0.0005 / 1g polymer, under a nitrogen atmosphere, and stir rapidly to disperse the catalyst evenly; then vacuumize to 50 Pa, and react at 220°C for 3 hours to obtain polyfumar Acid butylene glycol polyester prepolymer;

[0040] (2) Preparation of lactide monomer

[0041]Put 50 g of lactic acid and 0.3 g of catalyst into a 250 mL round bottom flask, and depressurize while heating. 3 Pa, keep warm and dehydrate for 2 hours, then raise the temperature to 180°C, and depressurize to 1.0×10 3 Pa, lactic acid polycondensation reaction dehydration, then replace the distillation device, rapidly r...

Embodiment 2

[0047] (1) Synthesis of polyfumaric acid glycol polyester prepolymer

[0048] Add fumaric acid, succinic acid and 1,4-propanediol (molar ratio: 0.4:0.6:1.05) into a three-necked flask, blow nitrogen gas for 30 minutes to remove the air in the system, connect a nitrogen air bag, and wait for the air bag to inflate Stop the ventilation, and stir the system at 200°C for 1 hour; then add a transesterification catalyst, 0.0005 / 1g of polymer, under a nitrogen atmosphere, stir rapidly to disperse the catalyst evenly; then vacuumize to 50 Pa, and react at 230°C for 3 Hour, obtain polybutylene fumarate / butylene succinate polyester prepolymer;

[0049] (2) Preparation of lactide monomer

[0050] Put 50 g of lactic acid and 0.27 g of catalyst into a 250 mL round-bottomed flask, and depressurize while heating. 3 Pa, keep warm and dehydrate for 2 hours, then raise the temperature to 200°C, and depressurize to 1.0×10 3 Pa, lactic acid polycondensation reaction dehydration, then replace ...

Embodiment 3

[0056] (1) Synthesis of polyfumaric acid glycol polyester prepolymer

[0057] Add fumaric acid and hexanediol (molar ratio: 1:1) into a three-necked flask, pass nitrogen gas for 30 minutes to remove the air in the system, connect a nitrogen air bag, stop the ventilation after the air bag expands, and put the system at 160°C Stir and react for 2 hours; then add a transesterification catalyst, 0.001 / 1g polymer, under a nitrogen atmosphere, and stir rapidly to disperse the catalyst evenly; then vacuumize to 50 Pa, and react at 180°C for 6 hours to obtain polyhexamethylene fumarate Alcohol ester polyester prepolymer;

[0058] (2) Preparation of lactide monomer

[0059] Add 50 g of lactic acid and 0.27 g of catalyst into a 250 mL round bottom flask, and depressurize while heating. 3 Pa, keep warm and dehydrate for 2 hours, then raise the temperature to 200°C, and depressurize to 6×10 2 Pa, lactic acid polycondensation reaction dehydration, then replace the distillation device, ...

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PUM

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Abstract

The invention relates to a method for preparing a macro-molecular polyester composite material with an adjustable biodegradation rate. The method comprises the following steps: (1) synthesizing a polyfumarate diol polyester prepolymer; (2) preparing a lactide monomer; (3) preparing a composite polylactic acid segmented copolymer; and (4) preparing and modifying a macro-molecular polyester composite material. According to the macro-molecular polyester composite material prepared by the method, the aim of regulating the biodegradation rate can be achieved by regulating changes of types and proportions of prepolymers in the segmented copolymer, and the polyester chain segment prepared by the method contains unsaturated double bonds, so that further modification for a material can be facilitated. The macro-molecular polyester composite material has an excellent application prospect.

Description

technical field [0001] The invention belongs to the field of biodegradable polymer materials, and in particular relates to a preparation method of a polymer polyester composite material with an adjustable biodegradation rate. Background technique [0002] With the continuous development of medical materials, biodegradable polymer materials have received extensive attention. According to different sources, biodegradable polymer materials can be mainly divided into the following three categories: naturally synthesized polymer materials, such as starch, chitin, protein, cellulose, etc.; microbially synthesized polymer materials, such as polyhydroxybutyrate , polyhydroxyvalerate, etc.; chemically synthesized polymer materials, such as polylactic acid, polybutylene succinate, polycaprolactone, etc. Among them, chemically synthesized biodegradable polymer materials have been paid more and more attention because of their advantages of strong plasticity, easy processing and low pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/08C08G63/78C08G63/52C08L67/06
CPCC08G63/08C08G63/52C08G63/78C08G2230/00C08L67/06C08L2201/06
Inventor 朱志荣赵国庆谷红波王小荣
Owner TONGJI UNIV