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Drug for treating early-stage symptoms of chronic manganese poisoning

An early stage, manganese poisoning technology, applied in the direction of drug combination, anti-drug, block delivery, etc., can solve the problem of high urinary manganese excess rate, achieve the effect of relieving post-toxic symptoms, relieving dizziness, and eliminating symptoms

Inactive Publication Date: 2016-07-06
济南思拓新源医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Welders have a high rate of excess urine manganese

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Composition: Jinbuhuan 10g, Licorice 10g, Agrimony 8g, Shixiantao 10g, Golden Silk Brush 8g, Chutouhong 10g, Shijunzi 12g, Open Arrow 2g, Shujincao 10g, Fruit Upper Leaf 15g, Sanya Bitter Leaf 2g, 10g of weed flower root, 1g of golden leaf, 10g of ironwort, 15g of vine, 10g of drupe, 2g of jay, 10g of oxtail, 10g of chrysanthemum, 10g of water paulownia, 15g of ginseng flower and 10g of nocturnal ox. Preparation method: Step 1: Mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration of 90% that is 5 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and use percolation method at 2ml per minute Slowly percolate, collect the percolate, then concentrate under reduced pressure at 0.08Mpa to a paste with a relative density of 1.06 at 55°C, spray dry, the air inlet temperature of the spray dryer is 165°C, and the outlet air temperature is 85°C. ℃, and then crushed into powder to make dry cream powder; St...

Embodiment 2

[0040] Composition: Jinbuhuan 15g, Licorice 20g, Agrimony 12g, Shixiantao 15g, Golden Silk Brush 15g, Chutouhong 15g, Shijunzi 16g, Open Arrow 4g, Shujincao 20g, Fruit Upper Leaf 18g, Sanya Bitter Leaf 4g, 15g of weed flower root, 3g of golden leaf, 20g of ironwort, 18g of vine, 15g of drupe, 4g of jay, 20g of oxtail, 20g of chrysanthemum, 15g of water paulownia, 18g of ginseng flower and 20g of nocturnal ox. Preparation method: in the first step, mix the various raw materials of the traditional Chinese medicine in proportion, add ethanol with an alcohol concentration of 90% that is three times the mass of the mixture, heat and reflux for 2 hours, extract, and filter to obtain the first extract; filter to obtain The dregs of the dregs were added with ethanol with an alcohol concentration of 90% relative to the quality of the dregs of the dregs, heated to reflux for 2 hours, extracted, and filtered to obtain the second extract; the first extract and the second extract were combi...

Embodiment 3

[0043] Drug Toxicity Test

[0044] ①Acute toxicity test: 40 NIH mice, SPF grade, half male and half male, weighing 18-22 g, were used for acute toxicity test. The mice were randomly divided into two groups, 20 in every group, i.e. a control group and an administration group, fasted for 12 hours before the experiment; the medicine prepared in Example 1 of the present invention was dissolved in water, (concentration was 6g crude drug / ml, highest concentration) by gavage, the volume of gavage is 5ml / kg (that is, the single dose is 30g crude drug / kg), the control group is given the same amount of normal saline, and the administration is 2 times a day, and the interval between administration is 6 hours. Afterwards, the mice were continuously observed for 14 days, and the number of toxic reactions and deaths of the mice was recorded. The results of the experiment showed that compared with the control group, there was no significant difference in the mice after administration. Aft...

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PUM

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Abstract

The invention discloses a drug for treating early-stage symptoms of chronic manganese poisoning. The drug is prepared from basil, licorice roots, a hairyvein agrimonia herb, a Chinese pholidota herb, shorthairy antenoron, a Nepal fleshspike herb, quispualis indica, tupistra delavayi, a beefwood-like clubmoss herb, a denseflower bulbophyllum herb, thin evodia twigs and leaves, roots of Procumbent Indian Mallow, Yunnan craibiodendron leaves, a bermudagrass herb, treebine stems, Ventilago leiocarpa Benth, Japanese aralia barks, riparian greenbrier roots and rhizomes, herba pyrolae, Ficus harlandii Benth, ginseng flowers and vernonia cinerea. The drug has the advantages that the drug can treat the early-stage symptoms of chronic manganese poisoning, can well relieve dizziness, headache, body aches, lower limb weakness and heaviness, hidrosis, heart palpitation, mood change and other symptoms through treatment, achieves the purposes of eliminating symptoms through basic regulation, accordingly relieves symptoms well after the poisoning and prevents further development.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine for treating the early stage symptoms of chronic manganese poisoning. Background technique [0002] With the development of my country's industry, the welding process is developing rapidly, and the types of welding and welding technology are constantly being updated, but arc welding is still the most widely used in industrial production. During arc welding, the welding rod and the metal base material produce a large amount of metal oxides under the arc temperature of 3000-6000 ℃, which are distributed into the air in the form of aerosol, and form welding smoke after rapid condensation. Welding fume contains a variety of elements, mainly manganese, iron and so on. The dispersion of welding fume is very high, and the respirable dust with a particle size of <5 μm accounts for 94.2%. Welding fume can enter the human body through the respiratory tract and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P39/02
CPCA61K9/1652A61K9/2068A61K9/4858A61K36/09A61K36/11A61K36/185A61K36/25A61K36/258A61K36/28A61K36/45A61K36/484A61K36/59A61K36/60A61K36/72A61K36/73A61K36/754A61K36/83A61K36/87A61K36/896A61K36/898A61K36/899A61K2300/00
Inventor 李光杰刘灿珍
Owner 济南思拓新源医药科技有限公司
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