New application of pharmaceutical composition of acyclovir and acipimox in field of medicines

A composition and drug technology, applied in the field of biomedicine, can solve problems such as no reports related to chronic nephritis, and achieve the effects of outstanding substantive characteristics, remarkable progress and remarkable therapeutic effect.

Inactive Publication Date: 2016-07-13
李月升
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there has been no report on the correlation between the pharmaceutical composition of acyclovir and acipimox and chronic nephritis

Method used

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  • New application of pharmaceutical composition of acyclovir and acipimox in field of medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: to the therapeutic effect of rat chronic nephritis model

[0019] The experiment adopts the improved cationization bovine serum albumin (induced chronic glomerulonephritis model, which is one of the animal models of choice when currently studying therapeutic drugs. The positive control drug is Tripterygium glycosides tablets Detect changes in biochemical indicators such as urine protein, serum creatinine, and urea nitrogen in experimental rats, make stained pathological sections of kidney tissue, and observe the pathological changes under a light microscope.

[0020] 1. Experimental materials

[0021] (1) Experimental animals

[0022] 90 SD rats (healthy and clean grade), half male and half male, weight standard: 200±15g. Purchased from the Experimental Animal Center of Heilongjiang University of Traditional Chinese Medicine, experimental animal qualification certificate number: SCXK black 2014-004. The laboratory is equipped with exhaust and ventilatio...

Embodiment 2

[0083] Embodiment 2: the preparation of tablet

[0084] Preparation of the composition of acyclovir and acipimox, as well as salts made of organic acids such as tartaric acid, or citric acid, formic acid, oxalic acid, etc., inorganic acids such as hydrochloric acid, sulfuric acid or phosphoric acid, adding excipients in conventional proportions Tablet granulation.

Embodiment 3

[0085]Embodiment 3: the preparation of oral liquid

[0086] Preparation of the composition of acyclovir and acipimox, as well as salts made from organic acids such as tartaric acid, or citric acid, formic acid, oxalic acid, etc., inorganic acids such as hydrochloric acid, sulfuric acid or phosphoric acid, prepared by conventional oral liquid The law is made into oral liquid.

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Abstract

The invention discloses a new application of a pharmaceutical composition of acyclovir and acipimox in the field of medicines. The pharmaceutical composition provided by the invention contains acyclovir and acipimox, and weight part proportion of acyclovir to acipimox in the composition is 7:3 to 9:1. The pharmaceutical composition provided by the invention contains two chemicals, acyclovir and acipimox, commonly used in clinic, and study shows that treatment effect on chronic nephritis is obvious and is not significantly different from that of a positive medicine when acyclovir and acipimox jointly act and are in a certain weight part proportion ranging from 7:3 to 9:1, so that the pharmaceutical composition provided by the invention can be developed into a medicine used for treating the chronic nephritis. Compared with the prior art, the pharmaceutical composition provided by the invention has outstanding substantial characteristics and obvious progress.

Description

technical field [0001] The invention belongs to the field of biomedicine, relates to the new application of old drugs of acyclovir and acipimox, in particular to the new application of a pharmaceutical composition of acyclovir and acipimox in medicine. Background technique [0002] Chronic nephritis is a group of immune inflammatory diseases that originate in the glomerulus caused by various reasons. In recent years, due to the application of immunofluorescence technology and electron microscope, modern medicine has carried out systematic and in-depth research on the immune pathogenesis, pathological morphology and functional changes of chronic nephritis, but in terms of treatment, there is still a lack of specific drugs. [0003] Acyclovir is a synthetic purine nucleoside analogue. It is mainly used for various infections caused by herpes simplex virus, and can be used for initial or recurrent skin, mucous membrane, external genital infection and HSV infection in immunocom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/4965A61P13/12A61P29/00
CPCA61K31/522A61K31/4965A61K2300/00
Inventor 李月升
Owner 李月升
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