Oxygen-containing xanthene ketone modified polymer drug as well as preparation method and application thereof in preparation of antibacterial drugs

A polymer and xanthone technology, applied in the preparation of antibacterial drugs, oxygen-containing xanthone modified polymer drugs and the field of preparation thereof, can solve the problems of difficult biodegradation, environmental pollution, difficulty in synthesizing antibacterial agents, etc. Inhibition of bacterial characteristics, simple and convenient synthesis process, and the effect of good bacterial characteristics

Inactive Publication Date: 2016-07-13
WENZHOU MEDICAL UNIV
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the existing problems of difficult synthesis of antibacterial agents, easy to cause environmental pollution, and difficult biodegradation, the present invention provides a modified polymer drug containing oxyxanthone, its preparation method and its application in the preparation of antibacterial drugs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oxygen-containing xanthene ketone modified polymer drug as well as preparation method and application thereof in preparation of antibacterial drugs
  • Oxygen-containing xanthene ketone modified polymer drug as well as preparation method and application thereof in preparation of antibacterial drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 1g of chitosan and place it in a three-necked bottle, add 20ml of deionized water, add 0.1ml of glacial acetic acid dropwise after stirring, stir until chitosan dissolves into a homogeneous solution, then add 100ml of absolute ethanol solution and stir evenly, 40 Heat in a water bath at ℃, add 0.5 g of oxyxanthone in 10 ml of ethanol solution dropwise, add 0.5 ml of catalyst, heat and stir for 5 h, adjust the obtained product to neutrality, filter, wash 5 times with ethanol-water mixed solution, and freeze-dry , and preserved to obtain the oxyxanthone-modified polymer drug.

Embodiment 2

[0023] Take 1g of chitosan and place it in a three-necked bottle, add 30ml of deionized water, add 0.5ml of glacial acetic acid dropwise after stirring, stir until chitosan dissolves into a homogeneous solution, then add 150ml of absolute ethanol solution and stir evenly, 60 Heat in a water bath at ℃, add 1.0 g of oxyxanthone-containing 10 ml ethanol solution dropwise, add 1.0 ml of catalyst, heat and stir for 10 h, adjust the obtained product to neutrality, filter, wash 5 times with ethanol-water mixed solution, and freeze-dry , and preserved to obtain the oxyxanthone-modified polymer drug.

Embodiment 3

[0025] Take 1g of chitosan and place it in a three-necked bottle, add 40ml of deionized water, add 1.0ml of glacial acetic acid dropwise after stirring, stir until chitosan dissolves into a homogeneous solution, then add 200ml of absolute ethanol solution and stir evenly, 75 Heat in a water bath at ℃, add 2.0g of oxyxanthone-containing 10ml ethanol solution dropwise, add 2.0ml of catalyst, heat and stir for 15h, adjust the obtained product to neutrality, filter, wash 5 times with ethanol-water mixed solution, freeze-dry , and preserved to obtain the oxyxanthone-modified polymer drug.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
viscosityaaaaaaaaaa
viscosityaaaaaaaaaa
Login to view more

Abstract

The invention relates to an oxygen-containing xanthene ketone modified polymer drug as well as a preparation method and application thereof in preparation of antibacterial drugs; the stable oxygen-containing xanthene ketone modified polymer drug is obtained by combining chitosan and 3-hydroxyl-9H-xanthene-9 ketone. Cell experiments prove that the polymer drug has a good characteristic of inhibiting bacteria. The preparation method of the oxygen-containing xanthene ketone modified polymer drug provided by the invention is environment-friendly as well as simple and convenient in synthetic process. After the method is adopted, a drug delivery system with a biologically-friendly characteristic can be prepared in an environment-friendly way, and a development direction of the polymer antibacterial drugs is also provided.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an oxantanone-modified polymer drug, a preparation method thereof, and an application in the preparation of an antibacterial drug. Background technique [0002] Escherichia coli, also known as Escherichia coli ( Escherichiacoli ), distributed in nature, most of them are not pathogenic, mainly attached to the intestinal tract of humans or animals, and are normal flora, and a small number of Escherichia coli are toxic and can cause diseases. If it enters the gallbladder, bladder, etc., it can cause inflammation. If E. coli is detected in water and food, it can be considered as an indicator of fecal contamination. Escherichia coli is often used as a hygienic standard for drinking water, food or medicine. [0003] Chitosan is the only alkaline polysaccharide that exists in nature. It has good antibacterial properties, non-toxic, non-irritating, non-immune antigenicity, and has...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/352C08B37/08A61P31/04
CPCA61K31/352C08B37/003
Inventor 程如梅齐蕾薛裕华林蜜蜜步叶旭葛聪聪陈路呀戴黎明
Owner WENZHOU MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap