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A medicinal injection of lincomycin hydrochloride composition and preparation method of its formula and medicinal preparation

A technology of lincomycin hydrochloride and injection, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, drug delivery, etc., can solve the problem of inactivity, and achieve the effect of simple operation and large industrial practical value

Inactive Publication Date: 2019-01-25
安徽延寿堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this product is a narrow-spectrum antibiotic, inactive against fungi and Gram-negative bacteria

Method used

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  • A medicinal injection of lincomycin hydrochloride composition and preparation method of its formula and medicinal preparation
  • A medicinal injection of lincomycin hydrochloride composition and preparation method of its formula and medicinal preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] In Example 1, please write out the detailed preparation method.

[0015] One of the medicinal injection formulations of lincomycin hydrochloride pharmaceutical composition:

[0016] Material name Material consumption

[0017] Lincomycin hydrochloride 3.0kg (calculated as lincomycin)

[0018] Baicalin (purity higher than 96% for injection) 75g

[0019] Sodium bisulfite 21g

[0020] Activated carbon 1.2㎏

[0021] Water for injection 10000mL

[0022] The preparation method is:

[0023] (1) Add about 60% of the water for injection into the dispensing container, control the water temperature at 35°C-38°C and add lincomycin hydrochloride, stir for 30-35min until completely dissolved; (2) Continue to add to the above solution Baicalin, stirred for 16-18min until completely dissolved;

[0024] (3) Add activated carbon and stir for 12 minutes; (4) Adjust the pH to 4.0-5.0 with 0.1mol / L sodium bisulfite solution or 0.1mol / L hydrochloric acid solution; (5) Dilute with water...

Embodiment 2

[0028] The second medicinal injection formulation of the lincomycin hydrochloride pharmaceutical composition:

[0029] Material name Material consumption

[0030] Lincomycin hydrochloride 1.0kg (calculated as lincomycin)

[0031] Baicalin (purity higher than 96% for injection) 25g

[0032] Sodium bisulfite 7g

[0033] Activated carbon 0.6kg

[0034] Water for injection 5000mL

[0035] The preparation method is the same as above (omitted).

Embodiment 3

[0036] Example 3 Vascular irritation test samples: the experimental group mixed the pharmaceutical injection of the lincomycin hydrochloride pharmaceutical composition of the above-mentioned embodiment 1 into 100 mL of 5% glucose injection, and the negative control group was 100 mL of 5% glucose injection.

[0037] Test method: Japanese big-eared white rabbits, weighing 2-2.5kg, were raised in the animal room for one week before the experiment to adapt to the environment. Five rabbits were used, and the experimental group was injected with 5 mL / kg in the right ear vein of the rabbits, and the negative control with the same injection amount was injected into the left ear vein. Use a No. 6 scalp needle to inject into the ear vein. The direction of the needle point to puncture the blood vessel is from the distal end to the proximal end, and the administration speed is 2-3mL / min. Dosing once a day for 7 consecutive days. The animals and the injection site were visually observed ...

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Abstract

The invention provides a medicinal injection of a lincomycin hydrochloride composition, a formula of the medicinal injection and a preparation method of a medicinal preparation.According to the medicinal injection prepared from the lincomycin hydrochloride composition, the limit that lincomycin hydrochloride is narrow-spectrum antibiotic is overcome, and the clinical application of treatment effect activity on fungi and gram-negative bacteria is added.The medicinal injection is produced industrially and is simple in process, and quality is easy to control.

Description

technical field [0001] The invention relates to the technical application field of pharmaceutical preparations, in particular to a pharmaceutical combination of lincomycin hydrochloride injection and a preparation method thereof. Background technique [0002] Lincomycin hydrochloride is a widely used antibiotic drug in clinical practice, suitable for respiratory tract infection, skin and soft tissue infection, female reproductive tract infection and pelvic infection caused by sensitive Staphylococcus, Streptococcus, Streptococcus pneumoniae and anaerobic bacteria and abdominal infection. In addition, for patients with indications for penicillin, such as patients who are intolerant to penicillin or who are not suitable for using penicillin, this product can be used as an alternative drug. However, this product is a narrow-spectrum antibiotic, inactive against fungi and Gram-negative bacteria. [0003] Baicalin ( Baicalin ) is a flavonoid compound extracted and isolated fro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7056A61K31/7048A61K9/08A61P31/04
CPCA61K9/0019A61K9/08A61K31/7048A61K31/7056A61K47/02A61K2300/00
Inventor 邓学峰李东明郑莉敏张怡倩
Owner 安徽延寿堂药业有限公司
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