Staged multi-strategy-based group conformation space sampling method
A technology of spatial sampling and population conformation, applied in the fields of bioinformatics and computer applications, can solve the problems of insufficient sampling ability and convergence speed
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[0049] The present invention will be further described below in conjunction with the drawings.
[0050] Reference Figure 1~2 , A group conformational space sampling method based on staged multi-strategy, including the following steps:
[0051] 1) Given input sequence information;
[0052] 2) Obtain the distance profile profile, rp from the QUARK server (http: / / zhanglab.ccmb.med.umich.edu / QUARK / ) according to the sequence information i Is the residue pair recorded in the distance spectrum, D i Is the distance between the residue pair, where i∈(1,N), N is the number of residue pairs in the distance spectrum;
[0053] 3) Setting parameters: population size NP, algorithm iteration number G, cross factor CR, stage factor s, set iteration algebra g = 0;
[0054] 4) Population initialization: NP initial conformations C are generated from the input sequence i , I={1,...,NP}, to assemble all position fragments of each conformation individual;
[0055] 5) For each conformational individual C in ...
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