Application of traditional Chinese medicine composition for preventing and treating thyroid nodules

A technology of composition and medicinal residues, applied in the field of traditional Chinese medicine composition and its preparations, can solve the problems of high incidence and high incidence of thyroid cancer, and achieve significant curative effect, clear curative effect, safe and gentle effect

Inactive Publication Date: 2016-08-03
YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thyroid nodules can be solitary or multiple. The incidence of multiple nodules is higher than that of single nodules, but the incidence of thyroid cancer in single nodules is higher

Method used

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  • Application of traditional Chinese medicine composition for preventing and treating thyroid nodules
  • Application of traditional Chinese medicine composition for preventing and treating thyroid nodules
  • Application of traditional Chinese medicine composition for preventing and treating thyroid nodules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Weigh the medicinal materials in the above composition, the vinegar green peel and vinegar frankincense, add water to decoct, extract the volatile oil, pack the obtained volatile oil with appropriate amount of auxiliary materials, and filter the decoction for later use. Add the above-mentioned vinegar green peel and vinegar frankincense dregs to the above-mentioned Prunella vulgaris, the above-mentioned Fritillaria and the above-mentioned medicinal materials of kelp, add water to decoct twice, filter the decoction, combine the above-mentioned decoction liquid, and concentrate to a relatively high temperature. For the extract with a density of 1.05-1.10, add ethanol to make the alcohol content reach 50%, leave it overnight, extract the supernatant, recover the ethanol and concentrate it to the extract with a specific gravity of 1.15-1.25 (60°C-65°C), dry, Pulverize, add appropriate amount of auxiliary materials such as sucrose, dextrin, stevia and volatile oil clathrate, ...

Embodiment 2

[0046] According to parts by weight, weigh green skin 150-299, frankincense 150-299, kelp 200-399, prunella vulgaris 200-399 and fritillaria 150-299, add green skin and frankincense to decoct, extract volatile oil, set aside, boil liquid Filter and set aside. Add the dregs of Prunella vulgaris, Fritillaria and Kelp, add 50v / v%~95v / v% ethanol and decoct three times, filter the decoction, combine it into the decoction liquid of frankincense frankincense, concentrate to 60℃~65℃ and the relative density is 1.15-1.25 concentrated solution, add volatile oil and appropriate amount of auxiliary materials, stir evenly, and make oral liquid, mixture, dropping pills and other dosage forms.

Embodiment 3

[0047] Embodiment 3: animal acute toxicity test

[0048] Experimental animals 22 purebred Kunming mice, half male and half female, were given 185g / kg / monkey / day by intragastric administration, and administered three times (according to crude drug calculation, equivalent to 209.5 times the clinical dosage), no obvious toxicity occurred in the animals before and after administration. Side effects, continuous observation for 7 days, no animal death, no abnormal performance.

[0049] Tests show that the dry extract of the composition extract has no obvious toxicity to experimental animals, suggesting that the clinical application of the medicine is safe.

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Abstract

The invention relates to a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by weight: 150-299 parts of green tangerine peel, 150-299 parts of frankincense, 200-399 parts of laminaria japonica, 200-399 parts of prunella vulgaris, and 150-299 parts of fritillaria. The traditional Chinese medicine composition has efficacy for softening hardness and dissipating binds, coursing liver and rectifying qi, and activating blood to remove stasis, and can be used for preparing medicines for preventing and treating thyroid nodules.

Description

technical field [0001] The present invention relates to a composition made by processing plants, in particular to a traditional Chinese medicine composition and its preparation, which are used for the prevention and treatment of thyroid nodules. Background technique [0002] Thyroid nodules are a common thyroid disease. There are many thyroid diseases clinically, such as thyroid degeneration, inflammation, autoimmunity, and neoplasms, which can all be manifested as nodules. Nodules on the thyroid may be thyroid cancer, thyroid tumors, and other causes such as nodular goiter, which are collectively referred to as thyroid nodules before their nature is clarified. Thyroid nodules can be single or multiple. The incidence of multiple nodules is higher than that of single nodules, but the incidence of thyroid cancer in single nodules is higher. Thyroid nodules can be divided into benign and malignant. Benign ones mainly include nodular goiter, thyroid adenoma and nodular changes ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/08A61K9/20A61P43/00
Inventor 郑璐吴斌范明松盛卫国丛海建朱汀滢刘文刚韩翠翠
Owner YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA
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