Application of total secondary ginseng glucoside in preparation of medicine for treating and/or preventing abnormal lipids metabolism after myocardial ischemia

A technology for abnormal lipid metabolism and total ginsenosides, which is applied in the field of medicine and can solve problems such as weak action strength

Inactive Publication Date: 2016-08-17
SHANGHAI HONGYITANG BIOPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These secondary saponins have many new activities, for example: ginseng secondary saponins Rh1, Rh2, Rg3 have obvious anti-cancer activity, can induce re-differentiation of cancer cells, can induce cancer cells to re-differentiate into healthy cells, other saponins body has no such effect, or the effect is weaker

Method used

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  • Application of total secondary ginseng glucoside in preparation of medicine for treating and/or preventing abnormal lipids metabolism after myocardial ischemia
  • Application of total secondary ginseng glucoside in preparation of medicine for treating and/or preventing abnormal lipids metabolism after myocardial ischemia
  • Application of total secondary ginseng glucoside in preparation of medicine for treating and/or preventing abnormal lipids metabolism after myocardial ischemia

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Embodiment 1

[0046] 1. Experimental steps

[0047] 1.1 Experimental materials

[0048] Total ginseng glycosides (prepared according to the method disclosed in ZL200510083855.6); diltiazem hydrochloride tablets (Tianjin Tanabe Pharmaceutical Co., Ltd.); isoproterenol (Sigma, St.Louis, MO, USA); creatine kinase (CK), aspartate Transaminase (AST), lactate dehydrogenase (LDH) kits (Sinobio Biotechnology Co., Ltd.); superoxide dismutase (SOD) and malondialdehyde (MDA) kits (Nanjing Jiancheng Technology Co., Ltd.) .

[0049] All lipid reference substances and internal standards were purchased from Avanti Company with a purity >98%; methyl tert-butyl ether (HPLC grade, J.T.Baker); acetonitrile (MS grade, J.T.Baker); methanol (pesticide residue grade, J.T. Baker); isopropanol, chloroform (both HPLC grade, Burdick & Jackson); ammonium formate, ammonium acetate (both HPLC grade, Sigma); formic acid (HPLC grade, TEDDIA); deionized water was prepared using a Millipore water purifier.

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Abstract

The invention relates to an application of total secondary ginseng glucoside, Rg3, Rg5 and / or Rk1 in preparation of a medicine for treating and / or preventing abnormal lipids metabolism after myocardial ischemia, and concretely relates to an application of total secondary ginseng glucoside, Rg3, Rg5 and / or Rk1 in preparation of the medicine for regulating fatty acid, sphingolipid, phosphoglyceride and glyceride levels in blood or cardiac muscle tissue after myocardial ischemia. The application of the invention makes a research of the protective effects of total secondary ginseng glucoside to heart of mice with myocardial ischemial injury from an angle of lipidomics, reveals mechanism of total secondary ginseng glucoside, and provides a brand new approach for treating myocardial ischemial injury.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to the application of ginsenosides, Rg3, Rg5 and / or Rk1 in the preparation of drugs for treating and / or preventing abnormal lipid metabolism after myocardial ischemia. Background technique [0002] Ginseng is the dried root of Araliaceae plant Panax ginseng C.A.Mey. Ginseng is an important medicine for invigorating Qi in traditional Chinese medicine. Nature, flavor and meridian distribution: sweet, slightly bitter, neutral. Functions and indications: tonify vital energy, restore pulse and solidify, invigorate the spleen and lung, promote body fluid, and soothe the nerves. For physical weakness, cold limbs, slight pulse, spleen deficiency, lack of food, lung deficiency, wheezing and coughing, body fluid wound thirst, internal heat and thirst, prolonged illness and deficiency, palpitations and insomnia, impotence and cold uterus; heart failure, cardiogenic shock. Panax notoginseng i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/704A61P9/10A61P3/06
Inventor 熊慧
Owner SHANGHAI HONGYITANG BIOPHARM CO LTD
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