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A process for large-scale production of Compatin and obtained high-purity Compatin
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A process and seed technology, applied in the field of medicine, to achieve the effect of improving purity, low production cost, and increasing yield
Active Publication Date: 2017-06-16
GUANGDONG BLUE TREASURE PHARMA
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The crude yield of mevastatin obtained by dry extraction of mevastatin is only 60%
Method used
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Embodiment 1
[0035] The seed culture medium is composed of the following components: white granulated sugar 45g / L, glycerol 30g / L, KH 2 PO 4 1g / L, MgSO 4 ·7H 2 O 1g / L, vitamin solution 0.1ml / L, add water to 1L; vitamin solution consists of vitamin B10.03g / L, vitamin B 2 0.01g / L and vitamin C 0.05g / L.
[0036] The fermentation medium is composed of the following components: white granulated sugar 45g / L, glycerol 30g / L, soybean powder 5g / L, KH 2 PO 4 0.5g / L, MgSO 4 ·7H 2 O 0.5g / L, plant extract 0.4g / L, add water to 1L; the plant extract is composed of Sophorae japonica extract and Emlica emblica extract in a volume ratio of 3:2.
[0037] The preparation technology of described Kang Baiting:
[0038] S1 Inoculate Penicillium citrinum in the above-mentioned seed medium for seed culture, and the culture conditions are as follows: temperature is 26°C, pressure is 0.04MPa, air flow rate is 0.5vvm, stirring speed is 100rpm, and the culture period is 62h; then inoculate Carry out ferment...
Embodiment 2
[0043] The seed culture medium is composed of the following components: white granulated sugar 52g / L, glycerol 40g / L, KH 2 PO 4 1.3g / L, MgSO 4 ·7H 2 O 1.2g / L, vitamin solution 0.3ml / L, add water to 1L; the vitamin solution is composed of vitamin B 1 0.08g / L, vitamin B 2 0.08g / L and vitamin C 0.1g / L.
[0044] The fermentation medium is composed of the following components: white granulated sugar 52g / L, glycerol 32g / L, soybean powder 7.5g / L, KH 2 PO 4 1g / L, MgSO 4 ·7H 2 O 1g / L, plant extract 0.8g / L, add water to 1L; the plant extract is composed of Sophorae japonica extract and Emlica emblica extract in a volume ratio of 4:1.
[0045] The preparation process of said Compatin is similar to Example 1.
Embodiment 3
[0047] The seed culture medium is composed of the following components: white granulated sugar 55g / L, glycerol 50g / L, KH 2 PO 4 3g / L, MgSO 4 ·7H 2 O 2g / L, vitamin solution 0.4ml / L, water is added to 1L; The vitamin solution is composed of vitamin B 1 0.1g / L, vitamin B 2 0.1g / L and vitamin C 0.1g / L.
[0048] The fermentation medium is composed of the following components: white granulated sugar 55g / L, glycerin 40g / L, soybean powder 10g / L, KH 2 PO 4 2g / L, MgSO 4 ·7H 2 O 2g / L, plant extract 1.2g / L, add water to 1L; the plant extract is composed of Sophora japonica extract and Emlica emblica extract in a volume ratio of 6:1.
[0049] The preparation process of said Compatin is similar to Example 1.
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to high-purity compactin and a process for producing the same on a large scale. Seed media for implementing the process for producing the high-purity compactin on the large scale mainly comprise white granulated sugar, glycerin, KN2PO4, MgSO4.7H2O, vitamin solution and water, and fermentation media mainly comprise white granulated sugar, glycerin, soybean meal, KH2PO4, MgSO4.7H2O, plant extract liquid and water. The high-purity compactin and the process for producing the high-purity compactin on the large scale have the advantages that the fermentative capacity of penicillium citrinum can be effectively enhanced by the aid of the media, and accordingly the compactin yield can be increased; impurities generated by the penicillium citrinum in fermentation procedures can be reduced, and accordingly the purity of the high-purity compactin can be improved; the process for producing the high-purity compactin is low in production cost, high in yield and purity and suitable for producing the high-purity compactin on the large scale.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a process for large-scale production of compatin and the obtained high-purity compatin. Background technique [0002] Combastatin, also known as mevastatin, is a secondary metabolite of fungi and belongs to the HMG-COA reductase inhibitor. Its function is to competitively inhibit HMG-CoA reductase, which is the rate-limiting enzyme of cholesterol biosynthesis. Conbatin was discovered by Akira Endo from the fungus Penicillium Citrinum in 1976, and was isolated from Penicillium brvicompactum by A.G. Brown in 1976. Its molecular formula is C 23 h 24 o 5 , the molecular weight is 390.52. [0003] Compactin can effectively lower cholesterol in the body, and its derivative, pravastatin, has stronger medicinal properties in lowering cholesterol. Compatin can be converted into pravastatin through the hydroxylation of a specific carbon in its structure, that is, Compatin ...
Claims
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