Dimetridazole soluble powder and preparation method thereof

A technology for the solubility of dimenidazole, which is applied in the field of veterinary chemical drug preparations, can solve the problems of low solubility of β-cyclodextrin, unresolved problems such as dimenidazole is difficult to dissolve in water, and cannot be administered in drinking water, so as to improve the Dissolution rate and saturation solubility, improving bioavailability and drug efficacy, and meeting the effect of clinical dosage

Active Publication Date: 2016-09-07
爱力迈(安徽)动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dimenidazole is off-white or slightly yellow powder, which is difficult to dissolve in water. Dimenidazole for livestock and poultry currently on the market is basically a premix that cannot be dissolved in water, and can only be mixed with ingredients for administration.
However, the current administration methods for large-scale poultry farming are mainly based on drinking water administration, so the clinical use of this product is greatly restricted
Both patents CN103432136A and CN103690940A describe the compound Dimenidazole product using anhydrous glucose as a carrier, but the simple mixing process of anhydrous glucose and Dimenidazole cannot increase the solubility of Dimenidazole
Patent CN102988363A describes a product in which Dimenidazole and β-cyclodextrin are co-ground through a 100-mesh sieve, and then mixed with raw and auxiliary materials such as polyvinylpyrrolidone and anhydrous glucose. The solubility of β-cyclodextrin in this prescription is low (1.8g / 100ml), easy to precipitate crystals from water, simple co-grinding of Dimenidazole and β-cyclodextrin through a 100-mesh sieve can not effectively improve the solubility of Dimenidazole, so it does not solve the problem of Dimenidazole water soluble problem
[0003] Dimenidazole is a chemical drug that is difficult to dissolve in water. The current marketed veterinary Dimenidazole product is a premix used for mixing materials and cannot be administered through drinking water.
The original Dimenidazole premix product can only be used as a mixing material and cannot be administered in drinking water; some original Dimenidazole and water-soluble anhydrous glucose simply mixed products need to dissolve 0.2g of the active ingredient in 1L of water More than 3 hours, can not meet the needs of large-scale breeding drinking water administration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A Dimenidazole soluble powder consisting of 20 parts of Dimenidazole, 10 parts of PVP K30, 3 parts of Poloxamer 188 and 67 parts of anhydrous glucose,

[0029] Its preparation method comprises the following steps:

[0030] (1) Micronization and pulverization: Add 20 parts of Dimenidazole into a side-wall vibrating pulverizer, pulverize and grind for 60 minutes, and discharge;

[0031] (2) Mixing: mix the above-mentioned 20 parts of Dimenidazole, 10 parts of PVP K30, 3 parts of Poloxamer 188 and 67 parts of anhydrous glucose to obtain a semi-finished product of Dimenidazole soluble powder with a content of 20%. ;

[0032] (3) Packing: The above-mentioned semi-finished products are weighed and passed the inspection, and put into aluminum foil bags for sealed storage.

Embodiment 2

[0034] A Dimenidazole soluble powder consisting of 20 parts of Dimenidazole, 10 parts of PVP K30, 3 parts of Poloxamer 188 and 67 parts of anhydrous glucose,

[0035] Its preparation method is characterized in that: it comprises the following steps:

[0036] (1) Micronized pulverization: Add 20 parts of Dimenidazole into the jet pulverizer for pulverization and discharge;

[0037] (2) Mixing: mix the above-mentioned 20 parts of Dimenidazole, 10 parts of PVP K30, 3 parts of Poloxamer 188 and 67 parts of anhydrous glucose to obtain a semi-finished product of Dimenidazole soluble powder with a content of 20%. ;

[0038] (3) Packing: The above-mentioned semi-finished products are weighed and passed the inspection, and put into aluminum foil bags for sealed storage.

Embodiment 3

[0040] A Dimenidazole soluble powder consisting of 20 parts of Dimenidazole, 10 parts of PVP K30, 2 parts of Poloxamer 188, 2 parts of sodium lauryl sulfate and 71 parts of anhydrous lactose,

[0041] Its preparation method comprises the following steps:

[0042] (1) Micronization and pulverization: Add 20 parts of Dimenidazole and 10 parts of PVP K30 into a side-wall vibrating pulverizer for pulverization and grinding for 90 minutes, and discharge;

[0043] (2) Mixing: Mix 20 parts of Dimenidazole, 10 parts of PVP K30, 2 parts of Poloxamer 188, 2 parts of sodium lauryl sulfate and 71 parts of anhydrous lactose to obtain a content of 20% Semi-finished products of Dimetridazole soluble powder;

[0044] (3) Packing: The above-mentioned semi-finished products are weighed and passed the inspection, and put into aluminum foil bags for sealed storage.

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PUM

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Abstract

The invention belongs to the technical field of veterinary chemical medicinal preparations, and particularly relates to a dimetridazole soluble powder and a preparation method thereof. The dimetridazole soluble powder is prepared from the following components in parts by weight: 18-22 parts of dimetridazole and 10-15 parts of hydrophilic carrier, and the balance of glucosum anhydricum or lactose anhydrous supplemented to 100 percent, wherein the hydrophilic carrier is one or more of PVP K30, poloxamer 188 and sodium lauryl sulfate. According to the dimetridazole soluble powder, the specific surface area of an insoluble medicine can be improved, and the wetting property can be increased, so that solubility of dimetridazole can be improved, the dissolving time is shortened, and the aim of clinical drinking water administration can be achieved. The dimetridazole has good bioavailability and good medicinal effect.

Description

technical field [0001] The invention belongs to the technical field of veterinary chemical drug preparations, and more specifically relates to a soluble powder of dimetridazole and a preparation method thereof. Background technique [0002] Dimenidazole is a broad-spectrum anti-anaerobic bacteria and antiprotozoal drug, which can effectively prevent and control poultry diseases such as histomoniasis in chickens, trichomoniasis in pigeons, treponema dysentery in swine, and trichomoniasis in bovines. Dimenidazole is an off-white or light yellow powder, which is difficult to dissolve in water. Dimenidazole for livestock and poultry currently on the market is basically a premix that is insoluble in water and can only be administered with mixing materials. However, the current administration method for large-scale poultry farming is mainly based on drinking water administration, so the clinical use of this product is greatly limited. Patents CN103432136A and CN103690940A both de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/4164A61K47/26A61K47/32A61K47/34A61K47/20A61P31/04A61P33/02
CPCA61K9/0095A61K9/146A61K31/4164
Inventor 张传斌陈剑英
Owner 爱力迈(安徽)动物药业有限公司
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