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Preparation method of Herba Sambuci Adnatae extract and application thereof in rheumatoid arthritis

A rheumatoid, blood-filled grass technology, applied in the field of plant extracts and their preparation, can solve the problems of inability to radically cure rheumatoid arthritis, inability to effectively control the development of the disease course, adverse reactions to chemical drugs, etc., and achieve treatment and relief of rheumatoid arthritis. Arthritis, improvement of foot swelling level, easy effect of temperature control

Inactive Publication Date: 2016-09-07
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no specific drug for this disease. Clinically, non-steroidal anti-inflammatory drugs, glucocorticoids, and disease-modifying antirheumatic drugs (DMARDs) are mainly used for maintenance treatment, but in the long run, the development of the disease cannot be effectively controlled.
In addition, chemical drugs have great adverse reactions, which many patients cannot bear, and there is a risk of drug-induced arthritis due to improper chemical drug treatment. The traditional method of treating rheumatoid arthritis in traditional Chinese medicine is mainly The medicine is applied externally on the affected area for treatment. Although this kind of prescription is safe, its effect is slow, and it can only relieve the symptoms of the disease, but cannot cure rheumatoid arthritis.

Method used

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  • Preparation method of Herba Sambuci Adnatae extract and application thereof in rheumatoid arthritis
  • Preparation method of Herba Sambuci Adnatae extract and application thereof in rheumatoid arthritis

Examples

Experimental program
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Effect test

Embodiment 1

[0021] A preparation method of Herba Smilax extract, it comprises the following steps:

[0022] Wash 250g of the rootless Herb Herb Powder, add 2500ml of water, soak at 80°C for 1 hour, filter, collect the filtrate, extract the filter residue four times by the above method, combine the filtrate, and then concentrate, recover the solvent during the concentration process, and freeze Dried to obtain the extract of the blood mulberry.

[0023] Lactose, crystalline fiber, magnesium stearate, diglycolic acid and ascorbic acid are added to the extract of Herba Cercis, and after uniform mixing, the granule medicine for treating rheumatoid arthritis is prepared.

Embodiment 2

[0025] A preparation method of Herba Smilax extract, it comprises the following steps:

[0026] Wash 250g of the root-cut Herb Herb Powder, add 1250ml of ethanol, heat and reflux at 80°C for 30min, then filter, collect the filtrate, extract the filter residue four times by the above method, combine the filtrate, and then concentrate, and recover the solvent during the concentration process Ethanol, after freeze-drying to obtain the extract of Herba Cauliflower.

[0027] Lactose, D-mannitol, magnesium stearate, diglycolic acid, ascorbic acid and water are added to the extract of Herba Mimosa, and after uniform mixing, the syrup medicine for treating rheumatoid arthritis is prepared.

Embodiment 3

[0029] A preparation method of Herba Smilax extract, it comprises the following steps:

[0030] Wash 250g of the rooted blood herb powder, the mixture of 1500mL water and ethanol (V 水 :V 乙醇 =1:1), extract in a microwave environment for 30-45min, the microwave frequency is 1000-2400MHz, the extraction temperature is 60°C, filter, collect the filtrate, repeatedly extract the filter residue four times with the above method, combine the filtrate, then concentrate, concentrate The solvent is recovered during the process, and the extract of C. sativa is obtained by freeze-drying.

[0031] Ethanol, propylene glycol, water, diglycolic acid and ascorbic acid are added to the extract of Herba Cinnamomi to make a granule drug and an injection drug for treating rheumatoid arthritis.

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Abstract

The invention discloses a preparation method of a Herba Sambuci Adnatae extract and an application thereof in rheumatoid arthritis, and relates to the technical field of a plant extract, and a preparation method and an application thereof. The preparation method comprises the following steps: after pulverizing Herba Sambuci Adnatae, adding 5-10 times of a solvent; repeatedly extracting for 4 times at the temperature of 35-100 DEG C; and then heating a concentrated solution and carrying out freeze drying to obtain the Herba Sambuci Adnatae extract. The prepared Herba Sambuci Adnatae extract is used for treating rat rheumatoid arthritis induced by II type collagen, and the result shows that the Herba Sambuci Adnatae extract can remarkably improve level of rat foot swelling caused by the rheumatoid arthritis induced by a freund's adjuvant, the IL-6 level of a skin reaction factor in serum can be reduced remarkably, and the food intake of a rat is not affected.

Description

technical field [0001] The invention relates to the technical field of plant extracts and their preparation methods and applications, in particular to the preparation methods of herb extracts and their application in rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a chronic, inflammatory, systemic autoimmune disease involving polyarticular synovitis lesions, characterized by non-suppurative inflammation of joints and joint tissues, mainly manifested as synovitis, Eventually, various tissues such as cartilage, ligaments, tendons and multiple organs of the joints will be damaged. Rheumatoid arthritis often invades the small joints of the limbs, such as hands, feet, and wrist joints. Rheumatoid arthritis without systematic treatment can be repeated for many years, eventually leading to joint deformities and loss of function. Evil deeply invades the liver and kidney, and dampness and wind-cold, wind-heat, and phlegm and fatigue are sandwiched togethe...

Claims

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Application Information

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IPC IPC(8): A61K36/35A61P19/02A61P29/00
CPCA61K36/35A61K2236/33A61K2236/331A61K2236/333A61K2236/39
Inventor 王文静李维熙王葳吕小满陈飞龙刘冬丽况秀平张美
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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