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Composition for treating acute radiation proctitis

A radiation proctitis and composition technology, which is applied in the directions of drug combination, plant raw materials, anhydride/acid/halide active ingredients, etc., can solve the problems such as bitter taste and cumbersome taste of traditional Chinese medicine decoction, achieve obvious efficacy, simple preparation process, The effect of good treatment

Inactive Publication Date: 2016-09-21
程晓磊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent No. 201010280094.4 discloses a traditional Chinese medicine decoction for treating acute radiation proctitis, which contains Chinese herbal medicines such as American ginseng, astragalus, angelica, Sanqi, etc. Before taking each time, the traditional Chinese medicine is decocted with water, which is cumbersome, and the traditional Chinese medicine decoction The taste is bitter and difficult to swallow, so it is very promising to prepare a composition for treating acute radiation proctitis that is simple to use, convenient to take, and economical

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The weight components of each raw material in the composition for treating acute radiation proctitis involved in this embodiment are: 10 parts of kudzu root, 10 parts of scutellaria baicalensis, 10 parts of bitter vegetable root, 10 parts of licorice root, 10 parts of betel nut, 15 parts of balsam pear, and 5 parts of pomegranate peel , 10 parts of Atractylodes macrocephala, 10 parts of purslane, 5 parts of Dendrobium, 10 parts of okra, 10 parts of fig, and 3 parts of rice vinegar; among them, bitter gourd, purslane, okra and fig are fresh products, and the temperature is controlled in a microwave oven for 60-70 ℃ drying, the total water content is less than 15%, and the rest of the plant raw materials are commercially available dry products; the preparation process is: after removing impurities and washing each dry product raw material, put it in a microwave oven, and dry at a temperature of 40-60 ℃ Surface water, cut various raw materials into block particles with a le...

Embodiment 2

[0015] In this embodiment, the composition for treating acute radiation proctitis prepared in Example 1 was selected for clinical research, and 64 patients with acute radiation proctitis in Qingdao Cancer Hospital were selected. The symptoms were blood in the stool, urgent stool, frequent defecation, tenesmus, and mucosal erosion. Intestinal wall necrosis; the treatment method is: take the composition capsule prepared in Example 1 after meals every day, 3 times a day, 5 capsules each time, 10 days as a course of treatment. After taking 3 courses of treatment, 31 cases were cured, and the clinical symptoms basically disappeared; 29 cases were effective, and the clinical symptoms were obviously improved; 4 cases were ineffective, and the clinical symptoms did not improve; the total effective rate reached more than 93%. See Toxicity.

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Abstract

The invention belongs to the technical field of preparation of traditional Chinese medicine compositions, and relates to a composition mainly prepared from natural Chinese herbal medicine for treating acute radiation proctitis. The composition is mainly prepared from the root of kudzu vine, scutellaria baicalensis, sow thistle roots, licorice roots, betel nut, bitter gourds, pomegranate bark, bighead atractylodes rhizome, purslane, dendrobe, okra and fig fruits. All the raw materials are cleaned, dried and cut into blocky granules, the raw material granules are weighed according to the weight matching ratios, the granules are mixed and placed into a marmite, rice vinegar is added, the granules are fried with a slow fire to be slightly yellow, the temperature is decreased to room temperature, the granules are ground into powder, and the powder is placed into a hollow capsule and sealed for use. The composition is scientific and reasonable in formula, simple in preparation technology, convenient to take and obvious in effect, has no side effect and has the good treatment effect on acute radiation proctitis.

Description

Technical field: [0001] The invention belongs to the technical field of preparation of traditional Chinese medicine compositions, and relates to a composition for treating acute radiation proctitis made of natural Chinese herbal medicines as main raw materials, which is used for oral administration to treat acute radiation proctitis. Background technique: [0002] Radiation proctitis is a common complication of pelvic radiation therapy. Women with cervical cancer, vulvar and vaginal cancer, and anorectal cancer should be treated with radioactive radium, cobalt, and cesium. These radioactive elements have inhibitory effects on cancer and normal There is also damage to the tissue, and when the rectal mucosa is damaged, radiation proctitis can be caused. Acute radiation proctitis refers to the acute proctitis caused by ionizing radiation exceeding the tolerance dose of the rectum within half a year. It is one of the common complications of radiotherapy for pelvic and abdominal ...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61K36/899A61P1/00A61K31/19
CPCA61K31/19A61K36/185A61K36/28A61K36/284A61K36/42A61K36/484A61K36/488A61K36/539A61K36/60A61K36/889A61K36/8984A61K36/899A61K2300/00
Inventor 程晓磊李新杨宁王蕾
Owner 程晓磊
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