Method for extracting alkanin from arnebia roots

A technology of shikonin and shikonin, which is applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of many by-products, expensive equipment, and low product purity, and achieve less by-products and easier operation easy effect

Inactive Publication Date: 2016-09-21
郭迎庆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem that the present invention mainly solves: in view of the current commonly used methods in the process of extracting shikonin, toxic organic solvents are often used. Although it is beneficial to speed up the process of extracting shikonin, the equipment is expensive and leads to many by-products. The current situation of product purity is not high, providing a method for extracting shikonin from the root of comfrey

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] First select 6 fresh comfrey roots, bury them completely in the soil in a light-proof environment, then cover the soil surface with straw, and then use a watering can to evenly spray the biogas digester supernatant onto the straw surface, spraying once every 6 hours, to keep the soil The moisture content is 68%. After 10 days, the roots of the comfrey are dug out, cleaned repeatedly manually, and the surface dirt is removed, and then cut into thin slices with a thickness of 1 mm; Under the condition of 85°C, cook for 20 minutes, discharge, and evenly spread the cooked comfrey root flakes on the stone grinding disc, and mix 200mL deionized water during the grinding process to obtain the comfrey root slurry; then weigh 0.06 Add 1 g pectinase and 0.03 g cellulase into the beaker containing the above-mentioned comfrey root slurry, then place the beaker on a digital speed measuring constant temperature magnetic stirrer, adjust the speed to 380r / min, and heat up to 40°C , sti...

example 2

[0023] First, select 7 fresh comfrey roots, bury them completely in the soil in a light-proof environment, and then cover the soil surface with straw, and then use a watering can to evenly spray the supernatant of the biogas tank on the surface of the straw, spraying once every 7 hours, to keep the soil The moisture content is 73%. After 11 days, the roots of the comfrey are dug out, cleaned repeatedly manually, and the surface dirt is removed, and then cut into thin slices with a thickness of 2mm; Under the condition of 90°C, cook for 25 minutes, discharge, and evenly spread the cooked comfrey root flakes on the stone mill, and mix 250mL deionized water during the grinding process to obtain the comfrey root slurry; then weigh 0.07 Add g pectinase and 0.04 g cellulase into the beaker containing the above-mentioned comfrey root slurry, then place the beaker on a digital speed measuring constant temperature magnetic stirrer, adjust the speed to 420r / min, and heat up to 45°C , st...

example 3

[0026] First select 8 fresh comfrey roots, bury them completely in the soil in a light-proof environment, then cover the soil surface with straw, and then use a watering can to evenly spray the supernatant of the biogas tank on the surface of the straw, spraying once every 8 hours, to keep the soil The water content is 76%. After 12 days, the roots of the comfrey are dug out, cleaned repeatedly manually, and the surface dirt is removed, and then cut into thin slices with a thickness of 3mm; Under the condition of 95°C, cook for 30 minutes, discharge the material, spread the cooked comfrey root flakes evenly on the stone grinding disc, mix 260mL deionized water during the grinding process, and obtain the comfrey root slurry; then weigh 0.08 Add 1 g pectinase and 0.05 g cellulase into the beaker containing the above-mentioned comfrey root slurry, then place the beaker on a digital speed measuring constant temperature magnetic stirrer, adjust the speed to 460r / min, and heat up to ...

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Abstract

The invention discloses a method for extracting alkanin from arnebia roots, and belongs to the technical field of alkanin preparation. The method comprises the following steps: firstly burying fresh arnebia roots into soil, irrigating the arnebia roots with a methane tank supernate which is rich in microorganism and presents faintly acid, then slicing the arnebia roots, obtaining arnebia root pulp after boiling and grinding, adding pectinase and cellulose, performing isothermal stirring and then performing enzyme deactivation treatment, adding ethyl alcohol and urea after the enzyme deactivation treatment, filtering to obtain filter liquor, heating the filter liquor to be boiled, adding dry ice to the filter liquor, removing the filter liquor through extraction filtration, washing filter cakes with deionized water, and drying the filter cakes, so as to obtain alkanin. The method is simple and convenient to operate, expensive equipment is not required, toxic organic solvent does not exist during the whole preparation process, the yield of the obtained alkanin is high while the cost is saved, by-products are less, and the method can be applied to industrial mass production.

Description

technical field [0001] The invention discloses a method for extracting shikonin from shikonin roots, belonging to the technical field of shikonin preparation. Background technique [0002] Comfrey, aliases: hard comfrey, soft comfrey. It is a herbal medicine included in the Chinese Pharmacopoeia, and its medicinal source is the dried root of Xinjiang Comfrey, Comfrey or Inner Mongolia Comfrey. The most important compounds in comfrey root are shikonaquinone compounds, mainly including shikonin, acetylshikonin, β,β-dimethylacryloylshikonin, isovalerylshikonin, isobutyrylshikonin Among them, the content of β,β-dimethylacryloylshikonin is the highest, followed by acetylshikonin, and the content of shikonin is the lowest. Shikonadhiquinone compounds have been identified by the National Cancer Institute of the United States as substances with anti-tumor activity. They have a wide range of biological activities including: antibacterial, anti-AIDS, promotion of burn wound healing,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C50/32C07C46/10A61K31/122A61P31/12A61P1/16
CPCC07C46/10A61K31/122A61K36/30
Inventor 郭迎庆张明许博伟
Owner 郭迎庆
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