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Experimental animal model for converting non-alcoholic steatohepatitis into liver cancer

A steatohepatitis, non-alcoholic technology, applied in the medical field, can solve the problems of long test period and unfavorable experimental research.

Inactive Publication Date: 2016-09-28
凯斯艾生物科技(苏州)有限公司
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Problems solved by technology

Although this model is closer to human NASH, the test period is too long, which is not conducive to experimental research, and is basically not adopted

Method used

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  • Experimental animal model for converting non-alcoholic steatohepatitis into liver cancer
  • Experimental animal model for converting non-alcoholic steatohepatitis into liver cancer
  • Experimental animal model for converting non-alcoholic steatohepatitis into liver cancer

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Embodiment Construction

[0010] The following will clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0011] In a preferred embodiment of the present invention, taking C57BL / 6 mice as an example, a method for making an animal model in which non-alcoholic steatohepatitis is transformed into liver cancer is provided, comprising the steps of:

[0012] (1) C57BL / 6 mice were bred and pregnant.

[0013] (2) Subcutaneous injection of STZ (200 micrograms per animal) on the back of offspring 24 hours after birth.

[0014] (3) The lactation period of offspring is 4 weeks. The mother mice were fed with normal standard feed du...

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Abstract

The invention belongs to the field of biotechnology, and relates to an experimental animal model for transforming nonalcoholic steatohepatitis into liver cancer. In particular, a large and mouse model of nonalcoholic chronic steatohepatitis (NASH) and chronic steatohepatitis developing into chronic liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) can be used for chronic fatty Liver, steatohepatitis, liver fibrosis, liver cirrhosis, hepatocellular carcinoma, metabolic diseases, diabetes, in vivo experiments of related mechanisms of diabetic complications, new drug development, and non-alcoholic steatohepatitis (NASH), liver It has extremely high application value in the study of the pathogenesis of fibrosis and liver cancer and in drug development.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for making an animal model of transforming nonalcoholic steatohepatitis into liver cancer in experimental rats and mice. The animal model constructed by the present invention can be used for chronic fatty liver, steatohepatitis, liver fibrosis, liver cirrhosis, hepatocellular carcinoma, metabolic diseases, diabetes, in vivo experiments of related mechanisms of diabetic complications, new drug research and development, in non- It has extremely high application value in the research and drug development of the pathogenesis of alcoholic steatohepatitis (NASH), liver fibrosis and liver cancer. Background technique [0002] The conversion of non-alcoholic steatohepatitis to liver cancer is one of the major liver diseases currently causing fatal liver diseases worldwide. A rapid, efficient, and low-mortality rodent model of nonalcoholic steatohepatitis conversion to liver ca...

Claims

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Application Information

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IPC IPC(8): A61K31/7008A01K67/02
CPCA61K31/7008A01K67/02A01K2207/25A01K2227/105A01K2267/03
Inventor 庄永杰陈继巧杨祖经邹筱芳王瑶李骥施婷李敏李鑫苏子龙梁荣发
Owner 凯斯艾生物科技(苏州)有限公司
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