Unlock instant, AI-driven research and patent intelligence for your innovation.
Toi toi flower extract microemulsion preparation and preparation method thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of extract and tortoise flower, which is applied in the field of medicine, can solve problems such as drug leakage, low drug loading, and poor preparation stability, and achieve the effects of controllable cost, simple equipment, and stable process
Active Publication Date: 2020-03-13
SHENZHOUSPACEBIOTECHGRP
View PDF3 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, this method has disadvantages such as low drug loading and uneven drug application; at the same time, the microcrystalline cellulose in the composition is easy to absorb moisture during storage, which promotes drug leakage and leads to poor stability of the preparation
[0005] Existing patents provide a new dosage form to improve the dispersibility of the toi toi extract, which improves the in vitro dissolution behavior to a certain extent, but does not fundamentally solve the problem of the solubility of the extract
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0036] The composition of the prescription is as follows:
[0037] Element Weight (g) Toi Dai flower extract (neohesperidin, naringin ≥ 50%) 5 Oleic acid 3 RH40 polyoxyethylene hydrogenated castor oil 2 Absolute ethanol 25 Deionized water 65.5 Sodium carboxymethyl cellulose 1.5
[0038] A total of 100g (toi toi flower extract content 5%)
[0039] Preparation Process:
[0040] Each component was weighed, and RH40 polyoxyethylene hydrogenated castor oil and oleic acid were mixed uniformly at 40°C. Dissolve the toi toi flower extract in absolute ethanol, add it to the oil phase, heat to 40°C until completely dissolved, and mix well. Stir the sodium carboxymethyl cellulose and deionized water evenly, mix the oil phase and the water phase at 35°C, and ultrasonicate for 5 minutes to form a clear primary microemulsion of the flower extract. The colostrum was homogenized under high pressure twice under the pressure of 500 bar to o...
Embodiment 2
[0042] The composition of the prescription is as follows:
[0043] Element Weight (g) Toi Dai flower extract (neohesperidin, naringin ≥ 50%) 10 Isopropyl myristate 5 Tween 80 2 polyethylene glycol 400 15 Deionized water 67.5 Sodium carboxymethyl cellulose 0.5
[0044] 100g in total (10% of toi toi flower extract)
[0045] Each component was weighed, and Tween 80 and isopropyl myristate were mixed uniformly at 35°C. Dissolve the toi toi flower extract in polyethylene glycol 400, mix with the oil phase, heat to 45°C until completely dissolved, and mix well. Stir the sodium carboxymethyl cellulose and deionized water evenly, mix the oil phase and the water phase at 45°C, and shear at high speed for 3 minutes to form a clear primary microemulsion of toi dai flower extract. The colostrum was homogenized under high pressure for 3 times under the pressure of 800 bar to obtain the microemulsion of the toi dai flower extract.
Embodiment 3
[0047] The composition of the prescription is as follows:
[0048] Element Weight (g) Toi Dai flower extract (neohesperidin, naringin ≥ 50%) 2 Isopropyl myristate 5 RH40 polyoxyethylene hydrogenated castor oil 3 polyethylene glycol 400 5 Deionized water 84 carbomer 1
[0049] A total of 100g (toi toi flower extract content 2%)
[0050]Each component was weighed, and RH40 polyoxyethylene hydrogenated castor oil and isopropyl myristate were uniformly mixed at 50°C. Dissolve the toi toi flower extract in polyethylene glycol 400, mix with the oil phase, heat to 50°C until completely dissolved, and mix well. Mix the carbomer with deionized water, mix the oil phase with the water phase at 50°C, and ultrasonically emulsify for 8 minutes to form a clear primary microemulsion of the flower extract. Put the colostrum microemulsion into a high-pressure homogenizer, homogenize twice at 1200 bar, and obtain the microemulsion of the tort...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Property
Measurement
Unit
particle diameter
aaaaa
aaaaa
wavelength
aaaaa
aaaaa
Login to View More
Abstract
The invention discloses a dai-dai flower extract microemulsion preparation. On the basis of a formula dosage of 100 g, the dai-dai flower extract microemulsion preparation comprises 2 to 20% of dai-dai flower extract, 2 to 15% of an emulsifier, 2 to 10% of a co-emulsifier, 5 to 10% of an oil phase, 0.5 to 1% of a stabilizing agent and 44 to 88.5% of deionized water. The above-mentioned components are mixed, heated, emulsified and homogenized at a high pressure so as to obtain a clear microemulsion solution with a brown-yellow to pale-yellow color. The invention also discloses a preparation method for the dai-dai flower extract microemulsion preparation. The preparation method comprises the following concrete steps: (1) weighing the dai-dai flower extract, the emulsifier, the co-emulsifier, the oil phase and deionized water in proportion; (2) preparing another oil phase; (3) preparing a water phase; (4) preparing primary microemulsion; and (5) preparing final microemulsion. The dai-dai flower extract microemulsion preparation has the characteristics of long-stem storability at room temperature, stable process, usage of simple equipment and controllable cost. Compared with the prior art, the invention provides a liquid dosage form of the dai-dai flower extract, and the liquid dosage form enables the dai-dai flower extract to be conveniently added into medicines, food, health products and cosmetics.
Description
technical field [0001] The technical field of medicine of the present invention specifically relates to a microemulsion preparation of toi toi flower extract and a preparation method thereof. Background technique [0002] Toi Dai (daidai) is a subgenus of citrus in Rutaceae. Toi Dai flower belongs to the homologous plant of medicine and food announced by the Ministry of Health, which can be added to medicines, health food, general food and cosmetics. Daidaihua is sweet in taste, bitter in taste, flat in nature, and has the effect of soothing the liver and regulating qi. Traditional Chinese medicine is used to treat symptoms such as indigestion, phlegm retention, fullness and pain in the chest and abdomen. [0003] The main components of the toi dai flower extract are neohesperidin and naringin (neohesperidin and naringin content ≥ 50%), which belong to flavonoids. Pharmacological experiments have proved that the toi toi flower extract has anti-oxidation function, has a good...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More