Fiber optic device enabling multiphoton imaging with improved signal-to-noise ratio

一种光学成像、光纤光学的技术，应用在光学、光学元件、测量装置等方向，能够解决没法穿过介入通道、探头尺寸大等问题

Active Publication Date: 2016-10-26
李兴德 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although this dual-fiber design is beneficial to collect more nonlinear fluorescent signals, it usually leads to the probe being too large in size to pass through the interventional channels of commercially available gastroscopes or colonoscopes (approximately 2.8– 4.0 mm diameter)

Method used

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  • Fiber optic device enabling multiphoton imaging with improved signal-to-noise ratio
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  • Fiber optic device enabling multiphoton imaging with improved signal-to-noise ratio

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Embodiment Construction

[0026] The presently disclosed subject matter will be described more fully hereinafter with reference to the accompanying drawings, showing some, but not all, possible embodiments of the invention. Like numbers refer to like elements. The presently disclosed subject matter may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will satisfy applicable legal requirements. In fact, many modifications and other embodiments for the presently disclosed subject matter will readily occur to those skilled in the relevant art, who are familiar with the art related to the disclosed subject matter of the present invention, having the teaching effect of the foregoing description and the associated drawings. Therefore, the presently disclosed subject matter should be understood not to be limited to the particular embodiments disclosed, but related modifications and oth...

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Abstract

The invention is directed to a fiber optic device that enables multiphoton imaging with improved signal-to-noise ratio having a single piece of double-clad fiber (DCF). The device also includes all components for focusing, scanning and signal collection within an endomicroscope probe of around 2 mm outer diameter. The unprecedented imaging capability of this miniature endomicroscope is demonstrated herein via both ex vivo and in vivo experiments.

Description

[0001] related application [0002] This application claims priority to the following patent application: U.S. Provisional Patent Application No. 62 / 169,712 (titled Fiber-Optic Methods and Devices Enabling Multiphoton Imaging with Improved Signal-to-Noise Ratio, filed June 2, 2015) for the aforementioned patent The contents of the application are incorporated by reference into this application for all purposes. technical field [0003] The invention relates to the field of imaging, in particular to a fiber optic method and device for realizing multi-photon optical imaging with enhanced signal-to-noise ratio. Background technique [0004] Due to their inherent optical tomographic properties, deeper penetration capabilities and reduced photodamage in out-of-focus regions, multiphoton microscopy, especially based on two-photon fluorescence (TPF) and optical second harmonic generation (SHG) signals Microscopic imaging has been widely used in basic biological and biomedical rese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B10/04
CPCA61B10/04A61B1/0017A61B5/0068A61B5/0084G01N21/636G01N21/6458G01N33/4833G01N2021/6478G01N2021/6484G01N2201/0866G01N2201/10G02B3/0087G02B21/0008G02B23/243G02B23/2469G02B23/26G02B26/103
Inventor 李兴德吴一聪梁文轩
Owner 李兴德
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