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Traditional Chinese medicinal compound preparation for treating IgA nephrosis with hyperuricemia, and preparation method and use thereof

A technology of hyperuricemia and compound preparations, which is applied in the field of Chinese medicine compound preparations for the treatment of IgA nephropathy complicated with hyperuricemia and its preparation, and can solve problems such as inability to reduce proteinuria and protect renal function

Active Publication Date: 2016-10-26
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Other urate-lowering drugs, such as allopurinol and benzbromarone, do not reduce proteinuria and preserve renal function

Method used

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  • Traditional Chinese medicinal compound preparation for treating IgA nephrosis with hyperuricemia, and preparation method and use thereof
  • Traditional Chinese medicinal compound preparation for treating IgA nephrosis with hyperuricemia, and preparation method and use thereof
  • Traditional Chinese medicinal compound preparation for treating IgA nephrosis with hyperuricemia, and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] A traditional Chinese medicine compound preparation, made of the following raw materials in parts by weight: 30 parts of buffalo horn, 15 parts of dried rehmannia root, 12 parts of red peony root, 10 parts of Moutan cortex, 30 parts of comfrey, 12 parts of atractylodes rhizome, 12 parts of Cortex Phellodendri , 12 parts of Chuan Achyranthes bidentata, 30 parts of coix seed, 30 parts of Smilax tuckahoe, 12 parts of 萆薢, 12 parts of plantain seed, 12 parts of white mustard seed, 6 parts of rhubarb, 15 parts of Atractylodes macrocephala and 12 parts of hawthorn.

[0073] Prepare the Chinese medicine compound preparation in the present embodiment according to the following steps:

[0074] (1) Mix the raw materials, add water 10 times the total weight of the raw materials to the mixture, soak for 45 minutes, decoct for 60 minutes, and filter to obtain medicinal juice a and filter residue b.

[0075] (2) Add water whose weight is 8 times the total weight of raw materials to fi...

Embodiment 2

[0078] A traditional Chinese medicine compound preparation, which consists of the following components in parts by weight: 25 parts of buffalo horn, 10 parts of dried rehmannia root, 8 parts of red peony root, 6 parts of Moutan cortex, 25 parts of comfrey, 12 parts of atractylodes rhizome, and 8 parts of Cortex Phellodendri , 8 parts of Chuan Achyranthes bidentata, 25 parts of coix seed, 25 parts of Smilax cocos, 8 parts of Chinese herb, 8 parts of plantain seed, 8 parts of white mustard seed, 3 parts of rhubarb, 10 parts of Atractylodes macrocephala and 8 parts of hawthorn.

[0079] According to the steps in Example 1, the Chinese medicine compound preparation in Example 2 was prepared.

Embodiment 3

[0081] A traditional Chinese medicine compound preparation, which consists of the following components in parts by weight: 35 parts of buffalo horn, 20 parts of dried rehmannia root, 16 parts of red peony root, 14 parts of Moutan cortex, 35 parts of comfrey, 16 parts of atractylodes rhizome, 16 parts of Cortex Phellodendri , 16 parts of Chuan Achyranthes bidentata, 35 parts of coix seed, 35 parts of Smilax tuckahoe, 16 parts of 萆薢, 16 parts of plantain seed, 16 parts of white mustard seed, 9 parts of rhubarb, 20 parts of Atractylodes macrocephala and 16 parts of hawthorn.

[0082] According to the steps in Example 1, the Chinese medicine compound preparation in Example 3 was prepared.

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Abstract

The invention discloses a traditional Chinese medicinal compound preparation for treating IgA nephrosis with hyperuricemia, and a preparation method and a use thereof. The traditional Chinese medicinal compound preparation comprises 25-35 parts of buffalo horns, 10-20 parts of dry rehmannia root, 8-16 parts of radix paeoniae rubra, 6-14 parts of Cortex Moutan, 25-35 parts of Lithospermum erythrorhizon, 8-16 parts of Atractylodes lancea, 8-16 parts of Amur Corktree Bark, 8-16 parts of Medicinal Cyathula Root, 25-35 parts of coix seeds, 25-35 parts of Glabrous Greenbrier Rhizome, 8-16 parts of rhizome of Dioscorea septemloba Thunb, 8-16 parts of Semen plantaginis, 8-16 parts of Semen Sinapis albae, 3-9 parts of rheum officinale, 10-20 parts of Rhizoma Atractylodis Macrocephalae and 8-16 parts of hawthorn fruits. The preparation adopting traditional Chinese medicinal components has mild and non-irritating medicinal effects, has the efficacy of clearing heat and cooling blood, and removing dampness and purging turbidity, can reinforce treatment of IgA nephrosis, effectively reduce proteinuria, uric acid and blood fat in order to restore the kidney functions, can treat the IgA nephrosis with hyperuricemia, is safe to take, and also has the advantages of reliable curative effect, and difficult recurrence of hyperuricemia.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations. More specifically, it relates to a traditional Chinese medicine compound preparation for treating IgA nephropathy complicated with hyperuricemia, its preparation method and application. Background technique [0002] IgA nephropathy (IgA Nephropathy, IgAN) is the most common primary glomerular disease, which refers to the glomerular mesangial area is dominated by IgA or IgA deposition, with or without other immunoglobulins in the glomerulus. Primary glomerulopathy with mesangial deposits. [0003] At present, IgA nephropathy is the most common type of chronic kidney disease (CKD) in my country and even in the world, accounting for about 40%-45% of primary glomerular diseases, and there is still a rising trend. IgA nephropathy mainly affects young adults, and at the same time IgA nephropathy is a progressive disease, about 20%-50% of patients will gradually develop into en...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K36/90A61P13/12A61P19/06A61K35/32
CPCA61K9/0095A61K35/32A61K36/21A61K36/284A61K36/30A61K36/31A61K36/65A61K36/68A61K36/708A61K36/71A61K36/734A61K36/756A61K36/804A61K36/8945A61K36/896A61K36/8994A61K36/90A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 张军军刘亚飞涂胜豪黄博余桂珍杜洋洋
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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