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A kind of detection method of Scutellaria baicalensis granule

A detection method and particle technology, which can be used in measuring devices, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of inspectors' physical injury, large reagent consumption, quality restrictions, etc., so as to shorten the detection time and reduce work. quantity, the effect of reducing errors

Active Publication Date: 2017-08-22
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

In addition, the quality of traditional Chinese medicine formula granules will also be restricted by detection methods. The traditional determination of moisture and ethanol extracts in Scutellaria baicalensis granules requires several hours by referring to the pharmacopoeia, and the operation is also complicated.
The main chemical component of Scutellaria baicalensis is baicalin. As a quality control index, the traditional method uses high-performance liquid chromatography, etc., which often requires complicated pretreatment of samples, consumes a lot of reagents, and pollutes the environment and inspectors. The body is damaged, and the information feedback is lagging behind, which cannot meet the needs of real-time analysis of multi-variety and multi-batch samples in the process of large-scale production of granule enterprises

Method used

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  • A kind of detection method of Scutellaria baicalensis granule
  • A kind of detection method of Scutellaria baicalensis granule
  • A kind of detection method of Scutellaria baicalensis granule

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Preparation of Scutellaria baicalensis granules: Take Scutellaria baicalensis decoction pieces, add water to decoct 3 times, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; combine the medicinal liquids, concentrate the filtrate to a clear paste with a relative density of 1.08 (80°C), Filter while hot with a 350-mesh sieve; spray-dry under the conditions of air inlet temperature 160°C, material pump speed 700 rpm, outlet air temperature 80°C, and air delivery temperature 40°C to obtain spray-dried powder; Aperture diameter 1.50mm, roller motor frequency 40HZ, feeding motor frequency 50HZ, oil cylinder pressure 20bar under the conditions of dry granulation to obtain Scutellaria baicalensis granules with a particle size of 40 mesh.

Embodiment 2

[0036] Preparation of traditional Chinese medicine preparations containing Scutellaria baicalensis: Take Scutellaria baicalensis pieces, add water to decoct 3 times, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; combine the medicinal liquids, and concentrate the filtrate to a relative density of 1.08 (80°C) The clear paste is filtered with a 350-mesh sieve while it is still hot; it is spray-dried under the conditions of an inlet air temperature of 160°C, a feed pump speed of 700 rpm, an outlet air temperature of 80°C, and an air supply temperature of 40°C to obtain a spray-dried powder; Dry granulation under the conditions of perforated plate aperture 1.50mm, roller motor frequency 40HZ, feeding motor frequency 50HZ, oil cylinder pressure 20bar, to obtain scutellaria granules with a particle size of 40 mesh; 188g scutellaria granules, 65g maltodextrin and 27g microcrystalline cellulose Mix well, add an appropriate amount of magnesium steara...

Embodiment 3

[0038] A method for rapidly detecting the moisture content of Scutellaria baicalensis granules based on near-infrared spectroscopy, specifically comprising the following steps:

[0039] a. Take samples of Scutellaria baicalensis granules, a total of 136 batches, about 3g each, grind into fine powder, put it into a stoppered glass sample bottle, place it on a near-infrared scanner for scanning, collect spectra, scanning conditions: scanning range 4000 -12000cm -1 , number of scans: 32 times, resolution 8cm -1 , the background is subtracted in real time during the scanning process, and 3 spectra are collected for each sample to obtain the following figure 1 The near-infrared original absorption spectrum of 136 batches of Huangqin granules shown;

[0040] At the same time, according to the standard method stipulated in the 2015 edition of the Chinese Pharmacopoeia, its moisture content was determined by the drying method. About 2 g of Scutellaria baicalensis granules that were ...

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Abstract

The invention discloses radix scutellariae particles and a traditional Chinese medicine preparation thereof. The radix scutellariae particles are prepared through the following steps that radix scutellariae decoction pieces are taken, water is added for decocting 2 times to 3 times, 5-10 times amount of water is added each time, and heating decocting is conducted for 1 h to 2 h; liquid medicines are mixed, filtrate is concentrated to obtain clear paste of which the relative density ranges from 1.02 to 1.10, and the clear paste is filtered with a 250-350-mesh sieve when the clear paste is hot; the clear paste is taken for spray drying, and spray-dried powder is obtained; the spray-dried powder is subjected to dry granulating, and the radix scutellariae particles of which the granularity ranges from 16 meshes to 40 meshes are obtained. According to the radix scutellariae particles and the traditional Chinese medicine preparation thereof, the preparation technology is simple, the technological parameters are easy to control, and the detection method is scientific, rapid and high in operability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a scutellaria granule and a traditional Chinese medicine preparation containing the scutellaria granules. Background technique [0002] Scutellaria baicalensis is derived from the dry root of Scutellaria baicalensis Georgi, a plant of the Labiatae family. It is bitter and cold, and returns to the lung, gallbladder, spleen, large intestine, and small intestine meridian. [0003] Traditional Chinese medicine granules are a series of traditional Chinese medicine products made of traditional Chinese medicine decoction pieces that meet the processing specifications, which are extracted, concentrated, dried, and granulated by modern industry. The new form of decoction pieces replaces the decoction pieces of traditional Chinese medicine for clinical syndrome differentiation and treatment, addition and subtraction according to the syndrome, and use. Com...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/359A61K36/539A61K9/16A61P7/04A61P15/06A61P39/02A61P29/00A61K125/00
CPCA61K9/1652A61K36/539A61K2236/331A61K2236/39A61K2236/51G01N21/359
Inventor 霍文杰朱德全刘丽萍潘礼业王闽予陈向东谭登平程学仁
Owner GUANGDONG YIFANG PHARMA
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