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Modification method for leukocyte filtering membrane

A filter membrane and white blood cell technology, applied in the field of white blood cell filtration, can solve the problems of not being able to remove platelets at the same time, the filtration rate is not ideal, and the platelet permeability of the filter membrane is high, so as to achieve low red blood cell damage rate, small dissolution rate, and promote capture Effect

Inactive Publication Date: 2016-11-16
广州新克力生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent application 02816396.6 discloses a leukocyte-removing filter material coated with units derived from hydrophobic polymerizable monomers, units derived from polymerizable monomers containing basic nitrogen-containing moieties on the surface of the filter material. Coating polymers composed of units and units derived from polymerizable monomers containing protic neutral hydrophilic moieties improve leukocyte and platelet filtration rates, but the filtration rates are still not ideal
[0006] Chinese patent application 201410106033.4 discloses a leukocyte filtration membrane, including a polybutylene terephthalate nonwoven fabric substrate and a grafted modified product grafted on the nonwoven fabric substrate, which is irradiated by γ-rays According to the grafting, the white blood cell filtration rate of the filter membrane is improved, but the filter membrane obtained has a high permeability to platelets and cannot remove platelets at the same time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 The first modified mixed solution

[0027] The first modified mixed solution is obtained by adding polyvinylpyrrolidone and fatty alcohol polyoxyethylene ether into water at a mass ratio of 3:1 and stirring, and the mass fraction is 4%.

Embodiment 2

[0028] Example 2 The first modified mixed solution

[0029] The first modified mixed solution is obtained by adding polyvinylpyrrolidone and fatty alcohol polyoxyethylene ether into water at a mass ratio of 4:1 and stirring, and the mass fraction is 5%.

Embodiment 3

[0032] Example 3 The second modified mixed solution

[0033] The second modified mixed solution is obtained by adding amidated silk fibroin and polyurethane into water at a mass ratio of 0.8:1 and stirring, and the mass fraction is 8%.

[0034] The preparation of amidated modified silk fibroin comprises the following steps: dissolve silk fibroin in water to make a solution with a concentration of 10 mg / mL, add 1 mol / L aqueous urea solution at a volume ratio of 1:5, mix well, and then use Dilute hydrochloric acid solution to adjust the pH value to 4.75, then add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride of 2 times the weight of silk fibroin, react at room temperature for 1h, and Add dilute hydrochloric acid solution appropriately during the process to keep the pH of the reaction solution at 4.75. After the reaction, add acetic acid buffer solution with a pH of 4.75 to decompose excess 1-(3-dimethylaminopropyl)-3-ethyl carbon diimine hydrochloride, and then di...

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Abstract

The invention relates to a modification method for a leukocyte filtering membrane. The modification method includes the following steps that S1, a hydrophobic resin filtering membrane is put in first modification mixed liquid for first-time impregnation for 0.5-2 h at the temperature of 20-40 DEG C and the pressure of 1-10 MPa, the hydrophobic resin filtering membrane is taken out, washed and then dried for 6-10 h at the temperature of 50-60 DEG C, and a first modified filtering membrane is obtained; S2, the first modified filtering membrane is put in second modification mixed liquid for second-time impregnation for 0.5-2 h at the temperature of 20-40 DEG C, the first modified filtering membrane is taken out, washed and then dried for 6-10 h at the temperature of 50-60 DEG C, and the modified filtering membrane is obtained. The modified filtering membrane obtained through the method has good wettability, stability and compatibility, blood platelets in fresh blood and blood preserved at normal temperature are activated to capture leukocyte, it is achieved that the leukocyte and the blood platelets are filtered out at the same time, and the filtering effect is good.

Description

technical field [0001] The invention belongs to the technical field of leukocyte filtration, and in particular relates to a method for modifying a leukocyte filtration membrane. Background technique [0002] Unprocessed whole blood or blood component preparations contain a large number of white blood cells, which will cause many side effects when transfused into the patient's body, so it is of great significance to filter out white blood cells. The leukocyte filtration method uses non-woven fabrics or porous materials with intercommunicating spaces as a filter membrane to filter out leukocytes, and is widely used in the filtration of leukocytes. [0003] The leukocyte filter membrane is generally made of a non-woven filter membrane made of very fine fiber materials. The ideal filter membrane should have the following characteristics: ultra-fine fiber diameter, small pore size of the filter material, large porosity, and excellent adsorption and wetting properties on the surfa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08L67/02C08L71/02C08L39/06C08L75/04C08L89/00B01D71/82B01D67/00
CPCC08J7/12B01D67/0093B01D71/82C08J2367/02C08L39/06C08L71/02C08L75/04
Inventor 王新平
Owner 广州新克力生物科技有限公司
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