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DIPA compounds as local reagents applied to treatment of sensory discomfort

A propylphosphonoheptane, topical technology for use in the field of therapeutic compounds

Inactive Publication Date: 2016-11-23
奥云达药业
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No biological activity of this diisopropyl compound has been previously reported

Method used

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  • DIPA compounds as local reagents applied to treatment of sensory discomfort
  • DIPA compounds as local reagents applied to treatment of sensory discomfort
  • DIPA compounds as local reagents applied to treatment of sensory discomfort

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0030] Embodiment 1: A therapeutic product comprising a compound of Formula 1 and a delivery vehicle carrying the compound of Formula 1 in said therapeutic product:

[0031]

[0032] Wherein, R is n-pentyl, n-hexyl, n-heptyl, and / or n-nonyl;

[0033] The delivery vehicle is suitable for topical delivery.

Embodiment approach 2

[0034] Embodiment 2: The therapeutic article of Embodiment 1, wherein the compound is 1-diisopropylphosphonopentane.

Embodiment approach 3

[0035] Embodiment 3: The therapeutic article of Embodiment 1, wherein the compound is 1-diisopropylphosphonohexane.

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PUM

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Abstract

The invention provides DIPA compounds as local reagents applied to treatment of sensory discomfort and generally relates to the field of therapeutic compounds. More particularly, the invention relates to certain DIPA compounds collectively known as DIPA-1-5, DIPA-1-6, DIPA-1-7, DIPA-1-8 and DIPA-1-9 in the specification. The DIPA compounds can be applied to treatment of symptoms such as sensory discomfort, skin dysesthesia, dermatitis, eye pain and discomfort, heat discomfort, heat stress, blush and / or night sweat, postoperative hypothermia, postanesthesia shivering, fatigue, tiredness, depression and cognitive dysfunction, and can be used for enhancing the cognitive function.

Description

technical field [0001] The present invention relates generally to the field of therapeutic compounds. More specifically, the present invention relates to certain diisopropylphosphonoalkanes (DIPA-1-5, DIPA-1-6, DIPA-1-7, collectively referred to herein as "DIPA compounds") as described herein. , DIPA-1-8, and DIPA-1-9), these diisopropylphosphonoalkanes are useful, for example, in the treatment of disorders (e.g., diseases) that include: sensory discomfort (e.g., caused by irritation, itching, or pain ), skin dysesthesia, atopic dermatitis, ocular pain and discomfort, thermal malaise, heat stress, flushing and / or night sweats (vasomotor symptoms), postoperative hypothermia, postanesthesia rigors, fatigue, exhaustion, Depression, cognitive impairment, and may be used to enhance cognitive function. The invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds and compositions, for example in therapy, diagnosis, and labora...

Claims

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Application Information

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IPC IPC(8): A61K31/662A61K49/00A61P29/00A61P17/04A61P17/00A61P27/02A61P25/24A61P25/28A61P43/00
Inventor 魏德烽
Owner 奥云达药业
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