Application of compound
A compound and drug technology, applied in the directions of heterocyclic compound active ingredients, drug combinations, cardiovascular system diseases, etc., can solve problems such as lack of cure for pulmonary hypertension, and achieve clinically significant effects
Inactive Publication Date: 2017-01-04
CHINA AGRI UNIV
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Problems solved by technology
These drugs can alleviate the symptoms of PAH to a certain extent. The median survival time of patients receiving treatment is only 2.7 years. At present, there is still no effective cure for pulmonary hypertension. Therefore, it is particularly important to find new specific therapeutic drugs
Method used
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Embodiment Construction
[0021] 2-Aminopurine (2-Aminopurine, 2-AP) was purchased from Sigma, USA.
[0022] Preferred embodiments of the present invention will be described in detail below in conjunction with examples. It should be understood that the following examples are given for the purpose of illustration only, and are not intended to limit the scope of the present invention. Those skilled in the art can make various modifications and substitutions to the present invention without departing from the purpose and spirit of the present invention.
[0023] The experimental methods used in the following examples are conventional methods unless otherwise specified.
[0024] The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.
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The invention relates to a compound, in particular to application of the compound shown in the structural formula (I) of 2-Aminopurine (2-AP) in pulmonary artery high pressure treatment. The 2-Aminopurine can be adopted as a unique active component for preparing a medicine for treating pulmonary artery high pressure. An experiment finds that the 2-Aminopurine has the effect of restraining pulmonary artery high pressure, and is particularly suitable for treating pulmonary artery high pressure caused by hyoxemia. The novel breakthrough is made for the 2-Aminopurine and pulmonary artery high pressure morbigenous molecular mechanism research, and the theoretical basis and target are provided for screening of the new medicine for treating secondary pulmonary artery high pressure and clinical treatment of pulmonary artery high pressure.
Description
technical field [0001] The present invention relates to the use of a compound. Background technique [0002] Pulmonary arterial hypertension (PAH) has complex etiology and is caused by a variety of heart, lung or pulmonary vascular diseases. The pathological features of pulmonary arteriole vascular remodeling and pulmonary artery smooth muscle proliferation. It is manifested by increased pulmonary circulation pressure and resistance, increased right ventricular load, right ventricular insufficiency, and reduced pulmonary blood flow, which can cause a series of clinical manifestations. Pulmonary hypertension often develops progressively during the course of the disease. Increased pulmonary artery vascular tone leads to right heart failure, a disease that seriously threatens human life and health. In particular, patients with idiopathic arterial PAH can only be diagnosed about 2 years after the onset of symptoms, and the natural course of the disease after diagnosis is 2.5-3...
Claims
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Login to View More IPC IPC(8): A61K31/52A61P9/12A61P11/00
Inventor 李向东王娜张静圆
Owner CHINA AGRI UNIV