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Externally-applied medicine for treating cutaneous appendages and skin pruritic disease and preparation method and application thereof

A technology for pruritic skin diseases and external use of drugs, applied in the field of biopharmaceuticals, can solve the problems of long course of treatment, single treatment, toxic and side effects, etc., and achieve the effects of rapid curative effect, improvement of immune system, and skin repair.

Inactive Publication Date: 2017-01-04
SHANGHAI MINGDA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the deficiencies of the prior art, to provide a kind of medicine for external use and its preparation method for treating skin appendages and pruritus skin disease, to solve the problem of single traditional medicine treatment, long course of treatment, long-term use and the existence of toxicity. Technical issues such as side effects

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  • Externally-applied medicine for treating cutaneous appendages and skin pruritic disease and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Materials:

[0030] The methods used in this example are conventional methods known to those skilled in the art unless otherwise specified, and the reagents and other materials used are all commercially available products unless otherwise specified.

[0031] 2. Method

[0032] 2.1 Preparation of NK cell stock solution

[0033] Step 1: PBMC extraction:

[0034] Centrifuge the fresh blood at 740g for 10 minutes to obtain the upper layer of light yellow plasma and the lower layer of blood cells, mix the lower layer of blood cells with normal saline at a volume ratio of 1:1, take a 50ml centrifuge tube, and spread the diluted blood cell suspension on 15ml of lymphocyte separation medium Centrifuge at 400g for 30 minutes. Collect the white membranous cell layer in the middle, add physiological saline to wash, centrifuge at 400g for 10 minutes, discard the supernatant, and repeat the washing once. Finally, the cell pellet was resuspended with an appropriate amount of c...

Embodiment 2

[0066] The present embodiment provides a kind of SNK liquid, by weight, described SNK liquid is composed of NK cell stock solution 70.0%, glycerol 5.0%, ethyl p-hydroxybenzoate 0.03%, borax 0.08%, peppermint oil 1.5% and appropriate amount of aseptic Water composition, wherein, the preparation method of described NK cell stock solution is the same as embodiment 1.

[0067] Select 3 patients with acne vulgaris and 2 patients with pruritus, spray the above-mentioned SNK solution directly on the affected area for treatment, use it 2-3 times a day, and count the clinical treatment results.

[0068] It was found that the above-mentioned SNK solution has a significant therapeutic effect on acne vulgaris, and the symptoms of severe patients are significantly relieved within 7 days, and can be cured after continuous use for 2 weeks; it has a certain therapeutic effect on pruritus, and mild patients can be cured within 2 weeks, and severe patients can be cured within 2 weeks. Symptoms ...

Embodiment 3

[0070] The present embodiment provides a kind of SNK paste, by weight, described SNK paste is composed of NK cell stock solution 60.0%, carbomer 941 is 0.5%, glycerin 5.0%, aloe vera powder 0.5%, ethyl p-hydroxybenzoate 0.5% , hyaluronic acid 0.3%, peppermint oil 1.5% and appropriate amount of water.

[0071] Select 2 patients with seborrheic dermatitis, use the above SNK ointment for smear treatment, use it 2-3 times a day, and count the clinical treatment results.

[0072] It was found that after 2 weeks of use, the symptoms of the two patients with seborrheic dermatitis improved significantly, indicating that the SNK ointment has a certain therapeutic effect on seborrheic dermatitis.

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Abstract

The invention discloses an externally-applied medicine for treating cutaneous appendages and skin pruritic disease and a preparation method and application thereof. The main component of the medicine is an NK cell stock solution which is obtained by amplifying and culturing NK cells. The NK cell stock solution is mixed with different medicine auxiliaries, and an externally-applied liquid preparation or externally-applied paste preparation can be prepared. Compared with the prior art, the externally-applied medicine can be directly used for treating acne, seborrheic dermatitis, pruritus, prurigo nodularis and other cutaneous appendages and skin pruritic disease and is rapid in treatment effect and meanwhile can improve the skin immune system and repair damaged skin according to the characteristics that protein and cell factors secreted by the NK cells can be easily absorbed by skin and can directly act on target cells. Secreted factors in the NK cell stock solution can kill fungi and bacteria, and the medicine achieves the aim of comprehensively treating acne, dermatitis and pruritus, is wide treatment range and can prevent repeated aggravation of pathogenetic conditions.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, in particular to a medicine for external use for treating skin appendages and pruritus skin diseases, a preparation method and application thereof. Background technique [0002] Acne vulgaris is a very common skin disease with 650 million patients worldwide. It is caused by the blockage of hair follicles and sebaceous glands, which leads to the proliferation of acne bacilli in the skin. It mostly occurs on the face, neck, chest, back and other parts with more sebaceous glands. Blackheads, whiteheads, red papules, pustules, cysts, etc. often appear, and may cause skin pigmentation or scarring. Acne affects the appearance, and patients with severe cases often suffer from great psychological pressure. The exact etiology is not yet clear, and factors such as androgen, sebum production, and acne bacillus infection may be involved, and heredity is also an important aspect. In patients with severe a...

Claims

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Application Information

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IPC IPC(8): A61K35/17A61P17/04A61P17/00
Inventor 卢玲琳李祥宇王苏鸣
Owner SHANGHAI MINGDA BIOTECH CO LTD
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