32 results about "Prurigo nodularis" patented technology

The present invention relates to methods of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cell. In particular, diseases or disorders including contact dermatitis, drug induced delayed type cutaneous allergic reactions, toxic epidermal necrolysis, cutaneous T cell lymphoma, bullous pemphigoid, alopecia aereata, vitiligo, acne rosacea, prurigo nodularis, and herpes simplex virus, or combination thereof will benefit from the administration of an IL-31 antagonist. The invention also includes methods of predicting a therapeutically responsive patient population.

The invention relates to a Chinese medicinal composition for treating skin diseases. The Chinese medicinal composition is prepared by stir-frying various Chinese herbal medicines such as phellodendron, baical skullcap root, manchurian wildginger, schizonepeta spike, bulbus fritilariae, golden larch bark, sulphur, realgar, toad venom, musk, mint rice, plant soot, salicylic acid and the like over slow fire, grinding accurately, mixing with badger fat, antelope oil and the like, grinding again and extracting. The Chinese medicinal composition can remove abnormal phlegmatic temperament, bile fluid and sepsis and relieve swelling and itching, and is used for treating parapsoriasis guttata (psoriasis), tinea manuum, tinea corporis, tinea pedis, tinea versicolor, intractable dermatitis, neurodermatitis, fungal skin diseases, leuconychia, purulent skin diseases, facial pityriasis, pityriasis rosea, seborrheic dermatitis, prurigo nodularis, scabies, eczema, herpes, acnes and the like.

The invention provides an itching-relieving washing medicine bag and a preparation method thereof, wherein the washing medicine bag is prepared from the following main materials in parts by weight: 20-30 parts of cortex pseudolaricis, 20-30 parts of radix stemonae, 10-20 parts of dried alum, 8-15 parts of fructus kochiae, 8-15 parts of fructus cnidii, 8-15 parts of fructus xanthii, 10-15 parts of hydnocarpus anthelmintica, 5-10 parts of pepper seeds, 10-20 parts of radix sophorae flavescentis, 10-20 parts of bark of himalayan coralbean, 10-20 parts of senecio scandens, 8-15 parts of purslane, 10-20 parts of tooth soap, 8-15 parts of folium artemisiae argyi, 8-15 parts of lithospermum, 8-15 parts of liquidambar formosana hance, 10-20 parts of calamine and 8-15 parts of mint. The itching-relieving washing medicine bag disclosed by the invention has effects of clearing heat and expelling damp, inhibiting bacteria and killing insects, diminishing inflammation, moistening skin, softening skin and promoting blood circulation, is not only convenient, but also is safe and environmentally friendly, and almost suitable for all crowds. Moreover, the itching-relieving washing medicine bag has remarkable treatment effect on pruritus skin diseases such as chronic eczema, hand-foot tinea corporis, scabies, miliaria, neurodermatitis, prurigo nodularis, amyloidosis, pruritus vulvae, urticaria papulosa, and the like, and especially has effects of getting twofold results with half the effort for the itching of thick skin which cannot be permeated by external-use ointment.

The present invention relates to methods of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cell. In particular, diseases or disorders including contact dermatitis, drug induced delayed type cutaneous allergic reactions, toxic epidermal necrolysis, cutaneous T cell lymphoma, bullous pemphigoid, alopecia aereata, vitiligo, acne rosacea, prurigo nodularis, and herpes simplex virus, or combination thereof will benefit from the administration of an IL-31 antagonist. The invention also includes methods of predicting a therapeutically responsive patient population.

The invention discloses a tincture and a preparation method thereof for treating prurigo nodularis, which is made of the following materials by weight proportions: 30-10 portions of cortex dictamni, 30-10 portions of khosam, 30-10 portions of selinum, 30-10 portions of broom cypress fruit, 30-10 portions of gallnut, 30-10 portions of red paeonia, 30-10 portions of trigone, 30-10 portions of rhizoma zedoariae, 30-10 portions of white caltrop, 30-10 portions of parsnip, 1200-400 portions of 75 percent alcohol. The preparation method is to soak the cortex dictamni, the khosam, the selinum, the broom cypress fruit, the gallnut, the red paeonia, the trigone, the rhizoma zedoariae, the white caltrop, and the parsnip in the 75 percent alcohol for ten days, and then to filter the medicine dregs; the obtained filtrate is the tincture for treating prurigo nodularis. The tincture has the beneficial effects that the tincture is pure herbal external tincture, can reduce damp fever, remove cold and stop itch, withdraw acerbity and dispel tubercle; can cure the prurigo nodularis effectively without side effect, and can be used conveniently.

This invention relates to compositions and methods of treatment of skin or mucosal disorders by administration of compositions comprising at least one EGFR inhibitor, such as topical compositions comprising erlotinib. The compositions of this invention are useful for the treatment, prevention or amelioration of skin or mucosal disorders like psoriasis, palmoplantar psoriasis, acquired palmoplantar keratosis, eczema, ichtyosis vulgaris, non-melanoma skin cancer, actinic keratosis, a keratinization skin disorder, a keratinization mucosal disorder, pachyonychia congenita, hidradenitis suppurativa, Gorlin syndrome, prurigo nodularis and prurigo pigmentosa.

A Chinese medicine for treating prurigo nodularis is prepared from more than 10 Chinese-medicinal materials including prunella spike, pumice, anemarrhena rhizome, earthworm, etc. Its advantages are sure curative effect, high safety, and no toxic by effect.

The invention relates to the field of medicines, and particularly relates to application of bulleyaconitine A. Bulleyaconitine A is applied to treating pruritus cutanea, and the situation that drugs such as antihistamines and hormones can produce unwelcome reactions so that the drugs cannot be applied for a long time and can only be applied intermittently, and thus pruritus recurs is avoided. Bulleyaconitine A has the positive effects when being applied to treating pruritus cutanea, has no liver and kidney toxicity side effects, can be applied for a long time, can control pruritus cutanea notto recur, and can avoid pachulosis and lichenification caused by unconscious scratching and secondary lesion such as eczema, neurodermatitis and prurigo nodularis. Bulleyaconitine A is applied to treating pruritus cutanea, solves the problem that a patient is troubled a lot by pruritus so that sleeping and resting of the patient are affected seriously because pruritus recurs at night, and effectively relieves the pain and mental stress of the patient and the family brought by pruritus.

The invention discloses a traditional Chinese medicinal composition for treating prurigo nodularis, which relates to the technical field of traditional Chinese medicine. Effective components of the traditional Chinese medicinal composition are prepared by adopting the following raw materials by weight part: 8 to 12 parts of codonopsis pilosula, 12 to 18 parts of astragalus membranaceus, 12 to 18 parts of rhizoma dioscoreae, 25 to 35 parts of semen coicis, 12 to 18 parts of radix rehmanniae preparata, 12 to 18 parts of poria cocos, 12 to 18 parts of grifola, 12 to 18 parts of semen plantaginis, 8 to 12 parts of atractylodes macrocephala, 12 to 18 parts of talcum, 8 to 12 parts of manyleaf paris rhizome, 12 to 18 parts of capillary wormwood, 12 to 18 parts of magnolia officinalis and 6 to 10 parts of liquorice. The traditional Chinese medicinal composition has the effects of tonifying the spleen, benefiting qi, enriching the blood, clearing heat, removing heat and toxic substances, dispelling dampness and the like, and is suitable for treating the prurigo nodularis of men and women of different ages.

The invention discloses a traditional Chinese medicine prescription for treating prurigo nodularis. The traditional Chinese medicine prescription is characterized by being prepared from the following Chinese herbal medicinal raw materials in parts by weight: 10-30 parts of gleditsia sinensis sting, 10-40 parts of radix rehmanniae preparata, 5-25 parts of cortex moutan, 5-25 parts of jasmine, 5-25 parts of angelica sinensis, 5-25 parts of radix bupleuri, 10-40 parts of poria cocos, 5-25 parts of white atractylodes rhizome, 5-25 parts of rhizoma sparganic, 5-25 parts of stiff silkworm, 5-25 parts of cassia twig, 2-8 parts of zaocys dhumnade, 10-40 parts of tribulusterrestris, 2-8 parts of wine-treated rhubarb and 5-15 parts of liquorice. The Chinese herbal medicinal raw materials in the traditional Chinese medicine prescription are pharmacologically synergetic, have the effects of tonifying spleen, tonifying qi, enriching the blood, clearing away heat and toxic materials, eliminating dampness and the like, and have the advantages of obvious curative effect for the treatment of the prurigo nodularis, no toxic and side effects, low treatment cost and the like.

A Chinese medicine for treating prurigo nodularis is prepared from more than 10 Chinese-medicinal materials including oyster shell, pumice, flavescent sophora root, etc. Its advantages are sure curative effect, high safety, and no toxic by effect.

Compositions and methods for treating skin conditions, ailments or diseases, such as autoinflammatory skin diseases such as psoriasis, dermatitis, pyoderma gangrenosum, palmoplantar pustulosis, prurigo nodularis and / or hidradenitis suppurativa, are described. The compositions comprise an agent that modulates the aryl hydrocarbon receptor, in particular an agent that agonizes the receptor. In one embodiment, the agent is indigo or a derivative of indigo, such as indirubin.

Technologically, the present invention aims at providing a kind of skin cream for treating chronic eczema, ramous eczema, neurodermatitis, prurigo nofularis and psoriasis, especially of middle-aged and old people. The skin cream consists of over ten kinds of medicine components, including Clobesolobetasol Propionate, mentholum, etc. The medicine for the present invention has fast and the curative effect on said skin diseases.

The invention discloses a preparation method of a compound clobetasol propionate liniment. The method comprises the steps that 1, propylene glycol is added to purified water to be stirred; 2, polyvinyl alcohol is completely soaked in mixed liquor in the first step, heating is conducted, and polyvinyl alcohol is completely dissolved; 3, clobetasol propionate and salicylic acid are weighed, peppermint oil is added, stirring is conducted, and the mixed liquor is added simultaneously; 4, ethylparaben is added and stirred simultaneously, after ethylparaben is completely dissolved, a sufficient amount of the purified water is added, and the liniment is obtained. After the liniment is smeared on the skin to form a film, hydration is produced to promote drug percutaneous absorption, the effects of relieving itching and dissolving cutin are improved, the liniment is used for topical therapies of prurigo nodularis, cutin thickening skin diseases, dermatitis and eczema, use is convenient and safe, and the therapeutic effect is good.

The invention discloses a traditional Chinese medicine for treating prurigo nodularis. The traditional Chinese medicine is prepared by decocting astragalus membranaceus, angelica sinensis, ligusticum wallichii, safflower carthamus, peach kernel, rhizoma smilacis glabrae, hedyotis diffusa, honeysuckle, fructus forsythia, caulis spatholobi, manyleaf paris rhizome, radix sophorae subprostratae, divaricate saposhnikovia root, scorpio, large centipede and water according to a certain proportion. By adopting pure traditional Chinese medicine formula, the traditional Chinese medicine provided by the invention has the effects of enriching blood and qi, dispelling wind and eliminating dampness, clearing away heat and toxic materials, removing stasis, dispelling wind and toxicity and removing stasis to relieve itching, can be used for effectively treating prurigo nodularis and is free of toxic or side effects.

The invention relates to the field of medicaments, in particular to the application of aconitin. The preparation of aconitin is used to treat skin pruritus, avoiding the adverse reactions caused by the application of antihistamines, hormones and other drugs, which cannot be used for a long time, and can only be used intermittently, resulting in the recurrence of pruritus. The application of ruconidin for the treatment of skin pruritus has a definite curative effect, no liver and kidney toxicity side effects, and can be taken for a long time to control recurrent skin pruritus and avoid unconscious scratching, which will cause rough skin and lichenification, which can lead to eczema, neuropathy, etc. Secondary lesions such as dermatitis and prurigo nodularis. It is used to prepare and treat skin pruritus, which relieves the pain and mental stress caused by pruritus in patients and their families.

The invention relates to a Chinese medicinal composition for treating skin diseases. The Chinese medicinal composition is prepared by stir-frying various Chinese herbal medicines such as phellodendron, baical skullcap root, manchurian wildginger, schizonepeta spike, bulbus fritilariae, golden larch bark, sulphur, realgar, toad venom, musk, mint rice, plant soot, salicylic acid and the like over slow fire, grinding accurately, mixing with badger fat, antelope oil and the like, grinding again and extracting. The Chinese medicinal composition can remove abnormal phlegmatic temperament, bile fluid and sepsis and relieve swelling and itching, and is used for treating parapsoriasis guttata (psoriasis), tinea manuum, tinea corporis, tinea pedis, tinea versicolor, intractable dermatitis, neurodermatitis, fungal skin diseases, leuconychia, purulent skin diseases, facial pityriasis, pityriasis rosea, seborrheic dermatitis, prurigo nodularis, scabies, eczema, herpes, acnes and the like.

The invention discloses a tincture and a preparation method thereof for treating prurigo nodularis, which is made of the following materials by weight proportions: 30-10 portions of cortex dictamni, 30-10 portions of khosam, 30-10 portions of selinum, 30-10 portions of broom cypress fruit, 30-10 portions of gallnut, 30-10 portions of red paeonia, 30-10 portions of trigone, 30-10 portions of rhizoma zedoariae, 30-10 portions of white caltrop, 30-10 portions of parsnip, 1200-400 portions of 75 percent alcohol. The preparation method is to soak the cortex dictamni, the khosam, the selinum, the broom cypress fruit, the gallnut, the red paeonia, the trigone, the rhizoma zedoariae, the white caltrop, and the parsnip in the 75 percent alcohol for ten days, and then to filter the medicine dregs; the obtained filtrate is the tincture for treating prurigo nodularis. The tincture has the beneficial effects that the tincture is pure herbal external tincture, can reduce damp fever, remove cold andstop itch, withdraw acerbity and dispel tubercle; can cure the prurigo nodularis effectively without side effect, and can be used conveniently.

Compositions, methods, and kits are provided for treating CCR8 mediated diseases with applicability to atopic dermatitis and potential applicability to asthma, prurigo nodularis, nummular dermatitis, neurodermatitis, and lichen simplex chronicus and some lymphomas, multiple sclerosis, acquired immunodeficiency disease, peritoneal adhesions, Kaposi's sarcoma and atherogenesis—the expression of all of which, at least in part, is mediated by cells expressing the chemokine receptor CCR8. The compositions include proteins and fusion proteins from Molluscum contagiosum Virus (MCV) or variants, analogs and derivatives thereof which exhibit inhibitory activity. Examples of such MCV proteins are MC148 fusion protein (MC148fp) identified as MC148P-TAT-6×His (“6×His” disclosed as SEQ ID NO: 11), and its variants, fragments, analogs and derivatives which possess inhibitory activity. The variants, fragments, analogs and derivatives of MC148p and of MC148fp may be less than 100% homologous to MCV proteins as long as they are sufficiently homologous that inhibitory activity is preserved.

The present invention provides, among other things, methods of treating pruritic or inflammatory skin diseases or disorders, or pruritus associated with a disease or disorder, with an anti-OSMRβ antibody, including methods of treating pruritus, associated with atopic dermatitis, chronic kidney disease-associated pruritus, uremic pruritus or prurigo nodularis, chronic idiopathic pruritus, chronic idiopathic urticaria, chronic spontaneous urticaria, cutaneous amyloidosis, lichen simplex chronicus, plaque psoriasis, lichens planus, inflammatory ichthyosis, mastocytosis and bullous pemphigoid, comprising a step of administering to a subject in need of treatment an anti-OSMRβ antibody at a therapeutically effective dose and an administration interval for a treatment period sufficient to improve, stabilize or reduce one or more symptoms of the disease or disorder relative to a control.

The invention belongs to a traditional Chinese medicine composition for treating prurigo nodularis. The traditional Chinese medicine composition is prepared by the following raw materials: angelica sinensis, ligusticum wallichii, radix rehmanniae, prepared rehmannia root, asparagus cochinchinensis, radix ophiopogonis, rhizoma atractylodis macrocephalae, poria cocos, oldenlandia diffusa, edible tulip, radix ranunculi ternate, rhizoma sparganii, curcuma zedoary, caulis spatholobi, peach kernel, safflower, bamboo mushroom, zaocys dhumnade, scorpio, centipede, schizonepeta, ledebouriella root, costus root, rice sprout, salvia miltiorrhiza, periostracum cicada, fried jujube kernels, semen boitae, glossy privet fruits, pilose asiabell root, dogwood and prepared liquorice. The traditional Chinese medicine composition provided by the invention is simple, convenient and quick in medicine application, easy to be accepted by patients, safe in medicine application and low in recurrence rate, and particularly is optimal in treatment effect on the wind heat accumulation and phlegm and blood stasis block type prurigo nodularis.

Compositions and methods for treating skin conditions, ailments or diseases, such as autoinflammatory skin diseases such as psoriasis, dermatitis, pyoderma gangrenosum, palmoplantar pustulosis, prurigo nodularis and / or hidradenitis suppurativa, are described. The compositions comprise an agent that modulates the aryl hydrocarbon receptor, in particular an agent that agonizes the receptor. In one embodiment, the agent is indigo or a derivative of indigo, such as indirubin.

The invention discloses an application of a traditional Chinese medicine composition in preparation of a medicine for treating prurigo nodularis, and belongs to the field of applications of traditional Chinese medicines. The traditional Chinese medicine composition comprises ginseng, leech, centipede, scorpio, ground beetle, cicada slough, red peony root, borneol, and the like. The traditional Chinese medicine composition has functions of tonifying qi, invigorating the circulation of blood, dispersing blood stasis and dredging collateral, and has good treating effects for the prurigo nodularis.

Compositions, methods, and kits are provided for treating CCR8 mediated diseases with applicability to atopic dermatitis and potential applicability to asthma, prurigo nodularis, nummular dermatitis, neurodermatitis, and lichen simplex chronicus and some lymphomas, multiple sclerosis, acquired immunodeficiency disease, peritoneal adhesions, Kaposi's sarcoma and atherogenesis—the expression of all of which, at least in part, is mediated by cells expressing the chemokine receptor CCR8. The compositions include proteins and fusion proteins from Molluscum contagiosum Virus (MCV) or variants, analogs and derivatives thereof which exhibit inhibitory activity. Examples of such MCV proteins are MC148 fusion protein (MC148fp) identified as MC148P-TAT-6xHis (“6xHis” disclosed as SEQ ID NO: 11), and its variants, fragments, analogs and derivatives which possess inhibitory activity. The variants, fragments, analogs and derivatives of MC148p and of MC148fp may be less than 100% homologous to MCV proteins as long as they are sufficiently homologous that inhibitory activity is preserved.

The invention discloses a traditional Chinese medicine for treating prurigo nodularis. The traditional Chinese medicine is prepared by decocting shrubberry rhodiola roots, tubers of smilax microphylla C. H. Wright., roots or rhizomes of cobaea scandens, seeds or leaves of daphniphyllum macropodum, Chinese lizardtail rhizomes or herb, Chinese knotweed herb, roots of iove-lies-bleeding, sweet wormwood herb, all-grass of ruellia drymophila (Diels) Hand.-Mazz., Yunbao herb, herba orostachyos, henry saruma roots and rhizomes, adenosma indianum and water at a certain proportion. By means of a pure traditional Chinese medicine formula, the traditional Chinese medicine has the effects of replenishing blood and tonifying qi, dispelling wind and eliminating dampness, clearing away heat and toxic materials, removing stasis and dispersing blood stasis, searching for wind and rejecting toxins, and dissipating blood stasis and relieving itching, and is capable of effectively treating prurigo nodulari and free of toxic or side effects.

Technologically, the present invention aims at providing a kind of skin cream for treating chronic eczema, ramous eczema, neurodermatitis, prurigo nofularis and psoriasis, especially of middle-aged and old people. The skin cream consists of over ten kinds of medicine components, including Clobesolobetasol Propionate, mentholum, etc. The medicine for the present invention has fast and the curative effect on said skin diseases.

The invention discloses an ointment formula used for treating dermatosis. The ointment formula used for treating dermatosis is composed of 400g of frankincense, 400g of myrrh, 250g of rosin, 300g of catechu, 400g of dragon' s blood, 300g of pearl, 300g of rhinoceros horn, 200g of calculus bovis, 100g of musk, 400g of borneol, 200g of amber, 300g of borneol, 300g of borax, 400g of pseudo-ginseng, 200g of charred human hair, 300g of cinnabar, 200g of rhizoma coptidis, 300g of pangolin, 200g of broom cypress fruit, 400g of toad venom, and 200g of calcined gypsum. The ointment formula can be used for treating skin diseases such as psoriasis, neurodermatitis, chronic eczema, epifolliculitis, cutaneous pruritus, prurigo nodularis, pityriasis rosea, tinea versicolor, ichthyosis, and keratosis pilaris.

Provided herein is a topical composition comprising roflumilast, roflumilast N-oxide or salts thereof as an active agent. The active agent in the composition of this invention is in encapsulated or non-encapsulated form, according to need.The above composition is useful for the treatment, prevention or alleviation of a skin disorder selected from Hidradenitis suppurativa and Prurigo nodularis.

This invention relates to compositions and methods of treatment of skin or mucosal disorders by administration of compositions comprising at least one EGFR inhibitor, such as topical compositions comprising erlotinib. The compositions of this invention are useful for the treatment, prevention or amelioration of skin or mucosal disorders like psoriasis, palmoplantar psoriasis, acquired palmoplantar keratosis, eczema, ichtyosis vulgaris, non-melanoma skin cancer, actinic keratosis, a keratinization skin disorder, a keratinization mucosal disorder, pachyonychia congenita, hidradenitis suppurativa, Gorlin syndrome, prurigo nodularis and prurigo pigmentosa.