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A dynamic culture instrument for tissue engineering using dynamic mechanical stimulation

A technology of tissue engineering and dynamic culture, which is applied in the field of biomedical tissue engineering, can solve the problems that the effect needs to be improved, and achieve the effect of realizing dynamic mechanical stimulation, improving mechanical properties, and low cost

Active Publication Date: 2019-04-16
PLASTIC SURGERY HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this kind of mechanical stimulation has a good promotion effect on the biomechanical properties of engineered tissues compared with static culture in the culture of engineered tissues, the effect still needs to be improved

Method used

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  • A dynamic culture instrument for tissue engineering using dynamic mechanical stimulation
  • A dynamic culture instrument for tissue engineering using dynamic mechanical stimulation
  • A dynamic culture instrument for tissue engineering using dynamic mechanical stimulation

Examples

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Embodiment Construction

[0035] The principles and features of the present invention are described below in conjunction with the accompanying drawings, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention.

[0036] Such as Figure 1 to Figure 7 shown, figure 1 It is a schematic diagram of the overall three-dimensional structure of a specific embodiment of a tissue engineering dynamic culture instrument that adopts dynamic mechanical stimulation provided by the present invention; figure 2 for figure 1 A schematic diagram of the structure of one of the incubator units in the specific embodiment shown after opening the upper cover; image 3 for figure 1 A schematic diagram of the structure of one of the incubator units in the specific embodiment shown after opening the upper cover and removing the front panel; Figure 4 for figure 1 A schematic diagram of the facade structure of one of the incubator units in the spec...

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Abstract

The invention relates to a tissue engineering dynamic culture system adopting dynamic mechanical stimulation. The dynamic culture system comprises one or more culture system units, wherein the culture system units comprise a box body, a drive motor, a controller, a rotary bracket, an attraction block, a culture bottle and a rotor; the culture bottle is arranged above the box body, and the bottom of the bottle is just opposite to the drive motor; the rotor is arranged in the culture bottle; at least one of the rotor and the attraction block is made of a magnetic material, and the both attract each other; the controller is in circuit connection with the drive motor; and the controller is provided with a speed control module and can control the drive motor to operate according to a set rotation speed. The culture system provided by the invention can realize common continuous constant shearing force stimulation, and can also produce a cyclically changing stirring speed through program setting, thus providing cyclic dynamic shearing force stimulation for a cultured engineering tissue and further improving the culture effect of the engineering tissue.

Description

technical field [0001] The invention relates to the field of biomedical tissue engineering, in particular to a dynamic culture instrument for tissue engineering using dynamic mechanical stimulation. Background technique [0002] Tissue engineering is an emerging discipline that combines cell biology and material science to construct tissues or organs in vitro or in vivo. Its basic principle is to obtain a small amount of living tissue from the body, use special enzymes or other methods to separate cells (also known as seed cells) from the tissue for culture and expansion in vitro, and then combine the expanded cells with good biological phase. Capacitive, degradable, and absorbable biomaterials (scaffolds) are mixed in a certain proportion to allow cells to adhere to the biomaterials (scaffolds) to form a cell-material complex; a tissue or organ disease in which the complex is implanted into the body As the biomaterials are gradually degraded and absorbed in the body, the i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00C12M1/36C12M1/24C12M1/10C12M1/02
CPCC12M21/08C12M23/08C12M27/02C12M27/10C12M35/04C12M41/42
Inventor 陆晓娜范飞徐奕昊
Owner PLASTIC SURGERY HOSPITAL CHINESE ACAD OF MEDICAL SCI
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