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Application of Linderolide H in preparation of drugs for treating rheumatoid arthritis

An arthritic and rheumatoid technology, which is applied in the application field of Linderolide H in the preparation of rheumatoid arthritis drugs, can solve the problems of poor action selectivity, ulcers, easy to induce infection, etc., and achieves outstanding substantive characteristics and strong inhibitory activity. Effect

Inactive Publication Date: 2017-01-25
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) are mainly used for treatment, but these drugs have obvious adverse reactions, such as the former damage Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection, etc.

Method used

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  • Application of Linderolide H in preparation of drugs for treating rheumatoid arthritis
  • Application of Linderolide H in preparation of drugs for treating rheumatoid arthritis
  • Application of Linderolide H in preparation of drugs for treating rheumatoid arthritis

Examples

Experimental program
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Effect test

Embodiment 1

[0011] Embodiment 1: Preparation of the compound Linderolide H tablet involved in the present invention:

[0012] Take 20 grams of compound Linderolide H, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.

Embodiment 2

[0013] Embodiment 2: the preparation of compound Linderolide H capsules involved in the present invention:

[0014] Take 20 grams of compound Linderolide H, add conventional excipients such as starch 180 grams for preparing capsules, mix well, and pack into capsules to make 1000 capsules.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0016] Experimental example 1, the influence of Linderolide H of the present invention on rat adjuvant arthritis

[0017] Grind Mycobacterium casei (Difco) and mix it with liquid paraffin to make 10 mg / ml, and make Freund's complete adjuvant after autoclaving. Male SD rats were intradermally injected with 50ul of the above-mentioned adjuvant in the right hind paw, and at the same time, injected 50ul intradermally at the tail about 3cm away from the base of the tail. The difference of , represents the degree of swelling. On the 16th day after the injection of the adjuvant, the swelling of the left hind paw of the rats was obvious. The rats were divided into groups according to the degree of swelling and body weight. The experimental group was orally given Linderolide H 5.0, 10.0, 20.0 mg / kg of the present invention, and the positive control group was orally given diclofenac 10 mg / kg, the control group was given the same volume of distilled water, once a day, for 7 consecutive ...

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Abstract

Linderolide H for treating immune inflammations is used to prepare drugs for treating rheumatoid arthritis; by using terfenadine and diclofenac as controls, Linderolide H has exact treatment effect; the application of Linderolide H related herein in the preparation of drugs for treating rheumatoid arthritis is disclosed for the first time; since a framework is of brand-new type and the inhibitory activity for rheumatoid arthritis is unexpectedly high, there is no chance for other compounds to give any indication and outstanding practical characteristics are provided; in addition, Linderolide H has significant progress in preventing and treating rheumatoid arthritis.

Description

technical field [0001] The present invention relates to a new application of compound Linderolide H, in particular to the application of Linderolide H in the preparation of drugs for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a clinical common disease and frequently-occurring disease. Rheumatoid arthritis belongs to autoimmune disease and belongs to the category of immune inflammation. At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) are mainly used for treatment, but these drugs have obvious adverse reactions, such as the former damage Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection. Therefore, compounds with well-defined components, controllable quality, safety and high efficiency have potential value in the development of drugs for rheumatoid arthritis. [0003] The comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P19/02
CPCA61K31/365
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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