HydroxyAnthraquinone Derivatives and Their Applications

A technology of hydroxyanthraquinones and hydroxyanthraquinones, which is applied in the field of antioxidants derived from microorganisms, can solve the problems of instability, high toxicity and side effects of antioxidants, DNA and protein damage, etc., and achieves short cycle, simple production process and low product cost Effect

Active Publication Date: 2019-01-08
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The production and removal of oxygen free radicals in the human body are in a balanced state under normal conditions, but when the balance is broken, excessive oxygen free radicals in the human body will lead to biofilm peroxidation, DNA and protein damage, and enzyme inactivation etc., leading to the occurrence of various diseases such as human aging and tumors
The artificially synthesized antioxidants currently on the market have the characteristics of large toxic side effects or instability

Method used

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  • HydroxyAnthraquinone Derivatives and Their Applications
  • HydroxyAnthraquinone Derivatives and Their Applications
  • HydroxyAnthraquinone Derivatives and Their Applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Talaromyces islandicus, a fungus of the genus Talaromyces islandicus, was preserved in the China General Microorganism Culture Collection Management Center, with a preservation date of March 17, 2016, and a preservation number of (CGMCC No.12224). The strain was green mycelium in the initial stage on the PDA plate, and orange-red spores grew on the surface of the mycelium in the later stage.

[0042] Example 1

[0043] Fermentative production and separation and purification of compounds 1 and 2:

[0044] 1) Fermentation production

[0045] Fermentation culture of production bacteria:

[0046] Strain culture: Talaromyces islandicus strains are agar-malt extract medium (agar-malt extract medium is malt extract 15g / L, agar 20g / L, pure seawater 1000mL, pH 7.4-7.8) , stored at 4°C. Get Talaromyces islandicus and inoculate it on a PDA plate, and cultivate it in an incubator at 28°C for 4 days;

[0047] Among them, Talaromyces islandicus, a fungus of the genus Talaromyces...

Embodiment 3

[0062] Embodiment 3: use half value clearance concentration (IC 50 ) method to detect the scavenging activities of compounds 1 and 2 on DPPH and ABTS free radicals

[0063] (I) Scavenging activity on DPPH free radicals:

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Abstract

The invention relates to microorganism derived antioxidant, in particular to a hydroxyl-anthraquinone derivative with antioxidant activity and application thereof. A structural formula of the hydroxyl-anthraquinone derivative is shown as a formula I, and the hydroxyl-anthraquinone derivative is prepared from talaromyces fungus Talaromyces islandicus by fermentation. According to experiments, the hydroxyl-anthraquinone derivative which is a compound has high activity in scavenging of radicals DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) and ABTS (2,2'-azine-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) and can be applied to preparation of antioxidation related drugs, food additives, cosmetic additives or the like.

Description

technical field [0001] The invention relates to an antioxidant derived from microorganisms, in particular to a hydroxyanthraquinone derivative with antioxidant activity and its application. Background technique [0002] With the development of life sciences, the occurrence and function of free radicals have gradually been deeply recognized and understood, and have been paid more and more attention by the academic circles. The production and removal of oxygen free radicals in the human body are in a balanced state under normal conditions, but when the balance is broken, excessive oxygen free radicals in the human body will lead to biofilm peroxidation, DNA and protein damage, and enzyme inactivation etc., thus leading to the occurrence of various diseases such as human aging and tumors. The artificially synthesized antioxidants currently on the market have the characteristics of large toxic side effects or instability. [0003] Studies have shown that anthraquinone compound...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C49/737C07C49/755A61P39/06
CPCC07B2200/07C07C49/737C07C49/755
Inventor 王斌贵李洪雷李晓明孟令红
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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