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Applications of compound traditional Chinese medicinal composition in preparing medicines for inhibiting skin melanoma lung metastasis

A compound traditional Chinese medicine, melanoma technology, applied in the directions of drug combination, anti-tumor drugs, pharmaceutical formulations, etc., can solve the problems of leukopenia, decreased NK cell activity, decreased body weight CD4/CD8 ratio, etc., and achieves low production price and easy promotion. Application, the effect of reducing the degree of lung metastases

Active Publication Date: 2017-03-22
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, patients will suffer from low immunity after using chemotherapy drugs. Animal experiments have shown that the body weight, spleen index, T lymphocyte proliferation activity, and CD4 / CD8 ratio of experimental mice after 5-fluorouracil intervention were significantly reduced, and leukopenia, Atrophy of immune organs, decreased phagocytosis of macrophages and decreased activity of NK cells

Method used

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  • Applications of compound traditional Chinese medicinal composition in preparing medicines for inhibiting skin melanoma lung metastasis
  • Applications of compound traditional Chinese medicinal composition in preparing medicines for inhibiting skin melanoma lung metastasis
  • Applications of compound traditional Chinese medicinal composition in preparing medicines for inhibiting skin melanoma lung metastasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A compound combination medicine for reducing pulmonary metastasis of melanoma, which is composed of the following components in parts by weight:

[0028] 15 roasted Astragalus, 15 fried Codonopsis, 10 fried Atractylodes, 15 Poria, 15 Chinese yam, 5 roasted licorice, 10 roasted black plum, 10 Sanleng, 10 Curcuma, 30 Agrimony, Paijiangcao 30 servings, a total of 11 herbs.

[0029] According to the prescription proportion, weigh the above 11 Chinese herbal decoction pieces, add water 10 times the total weight of the raw materials, decoct and extract 3 times, 1 hour each time. Combine the decoction to make the decoction.

[0030] The obtained decoction was concentrated to a relative density of 1.10 (measured at 60° C.), ethanol was added until the alcohol content reached 60%, and it was allowed to stand for more than 12 hours. The supernatant was collected by filtration, ethanol was recovered to the end, and concentrated to a relative density of about 1.10 (measured at 60...

Embodiment 2

[0032] A compound combination medicine for reducing pulmonary metastasis of melanoma, which is composed of the following components in parts by weight:

[0033] 15 roasted Astragalus, 30 fried Codonopsis, 10 fried Atractylodes, 20 Poria, 15 Chinese yam, 5 roasted licorice, 10 roasted black plum, 15 Sanleng, 15 Curcuma Radix, 30 Agrimony, Paijiangcao 30 servings, a total of 11 herbs.

[0034] According to the prescription proportion, weigh the above 11 Chinese herbal medicine pieces, add water 20 times the total weight of the raw materials, decoct and extract 3 times, 1 hour each time. Combine the decoction, concentrate to a relative density of 1.08 (measured at 60°C), add ethanol until the alcohol content reaches 60%, let stand for more than 24 hours, collect the supernatant by filtration, recover ethanol to the end, and concentrate to a relative density of about 1.08 ( measured at 60°C). Add distilled water to the equivalent of 1 g of decoction pieces per mL, mix evenly, fi...

Embodiment 3

[0036] A compound combination medicine for reducing pulmonary metastasis of melanoma, which is composed of the following components in parts by weight:

[0037] 20 roasted Astragalus, 20 fried Codonopsis, 15 fried Atractylodes, 15 Poria, 15 Chinese yam, 10 roasted licorice, 15 roasted black plum, 10 Sanleng, 10 Curcuma, 15 Agrimony, Paijiang 15 servings, a total of 11 herbs.

[0038] According to the prescription proportion, weigh the above 11 Chinese herbal medicine pieces, add water 5 times the total weight of the raw materials, decoct and extract 3 times, 1 hour each time. Combine the decoction, concentrate to a relative density of 1.10 (measured at 60°C), add ethanol until the alcohol content reaches 60%, let stand for more than 24 hours, collect the supernatant by filtration, recover ethanol to the end, and concentrate to a relative density of about 1.33 ( measured at 60°C). Adding an appropriate amount of dextrin and stevioside, granulating, drying, whole granulating, ...

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Abstract

The invention discloses applications of a compound traditional Chinese medicinal composition in preparing medicines for inhibiting skin melanoma lung metastasis. The compound traditional Chinese medicinal composition is prepared from the following components in parts by weight: 15-30 parts of radix astragali preparata, 15-30 parts of stir-baked radix codonops, 10-20 parts of stir-baked white atractylodes rhizome, 15-30 parts of poria cocos, 15-30 parts of rhizoma dioscoreae, 5-10 parts of radix glycyrrhizae preparata, 10-20 parts of smoked plum preparata, 10-20 parts of rhizoma sparganii, 10-20 parts of rhizoma curcumae, 15-30 parts of herba agrimoniae, and 15-30 parts of herba patriniae. The compound traditional Chinese medicinal composition provided by the invention can obviously inhibit the skin melanoma lung metastasis under the condition that the body immunity is not reduced, and meanwhile, the medicine is low in preparation cost, and easy to popularize and apply.

Description

technical field [0001] The invention relates to traditional Chinese medicine technology, in particular to the application of a compound traditional Chinese medicine composition in a medicine for inhibiting pulmonary metastasis of skin melanoma. Background technique [0002] Melanoma is the most important tumor type in dermatology. It originates from melanocytes at the junction of the epidermis and dermis, and can also originate from the mucosa or the choroid of the eye. This kind of tumor is relatively rare but the most malignant one. Its incidence rate is about 0.1 / 100,000 people in all non-developed countries, but its fatality rate accounts for 97%. It is prone to distant metastasis, especially lung metastasis. , it should be given great attention. [0003] With the change of Chinese people's lifestyle and environmental pollution, the overall incidence of cancer is increasing year by year. In addition to surgery, many first-line chemotherapy for cancer patients is still ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P35/04
CPCA61K36/076A61K36/284A61K36/344A61K36/481A61K36/484A61K36/73A61K36/736A61K36/84A61K36/8945A61K36/902A61K36/9066A61K2236/331A61K2236/39A61K2300/00
Inventor 周锦勇郭顺刘沈林陈玉根
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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