Preparation method and applications of glucosyl modified quantum dot fluorescent probe

A glucose-based and fluorescent probe technology, which is applied in the field of nanomaterial modification technology and biochemical analysis and detection, can solve the problems of non-specific recognition of quantum dots, and achieve the effects of wide detection concentration range, simple operation, and low detection limit

Pending Publication Date: 2017-04-19
GUANGXI TEACHERS EDUCATION UNIV
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Problems solved by technology

[0004] One purpose of the present invention is to solve the problem of non-specific recognition of quantum dots, and provide a material that has both the specific recognition of sugar and the special properties of quantum dots

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  • Preparation method and applications of glucosyl modified quantum dot fluorescent probe
  • Preparation method and applications of glucosyl modified quantum dot fluorescent probe
  • Preparation method and applications of glucosyl modified quantum dot fluorescent probe

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Embodiment Construction

[0035] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0036] It should be noted that the experimental methods described in the following embodiments, unless otherwise specified, are conventional methods, and the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0037] A kind of preparation method of glucosyl modified quantum dot fluorescent probe, its specific steps are as follows:

[0038] 1. Synthesis of sulfhydryl derivatized glucose:

[0039] 1) Formula 2 compound Synthesis

[0040] Weigh 1.44g of compound D-glucose of formula 1 and place it in a 100mL round bottom flask, add 50mL of pyridine (pre-drying treatment), stir under ice-salt bath conditions until the sugar is completely dissolved, add 10mL of benzoyl chloride dropwise, after the dropwise addition, naturally Rise to ...

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Abstract

The invention discloses a preparation method of a glucosyl modified quantum dot fluorescent probe. The preparation method comprises: adopting D-glucose as a raw material, carrying out hydroxyl complete protection and terminal glycosylation, adding a N,N-dimethylformamide solution and potassium thioacetate to catalyze, removing the protection group through sodium methoxide/methanol to obtain mercapto derivatized glucose, and modifying the mercapto derivatized glucose on the surface of quantum dots through ligand exchange to obtain the glucosyl modified quantum dot fluorescent probe. According to the present invention, the prepared glucosyl modified quantum dot fluorescent probe is used for detecting the pesticide fenpropathrin content; and the glucosyl modified quantum dot fluorescent probe has the specific recognition ability of sugar and the special properties of quantum dots, and further has advantages of good water solubility and long stabilization time, and the preparation method has advantages of short synthesis route of the glucosyl modified body, simple synthesis operation, simple preparation method of the modified quantum dots, and rapid preparation.

Description

technical field [0001] The invention relates to the fields of nanometer material modification technology and biochemical analysis and detection technology. More specifically, the present invention relates to a preparation method and application of a glucose-modified quantum dot fluorescent probe. Background technique [0002] Quantum dots (quantum dots, QDs) are semiconductor nanocrystals composed of IIB-VIA (for example: CdSe, CdTe, CdS and ZnSe) or IIIA-VA (for example: InP and InAs), generally spherical in shape, diameter size About 1 ~ 12nm. Quantum dots have unique optical properties, with a wide range of absorption spectra and adjustable and narrow emission spectra, and can display different colors and different emission waves through different quantum radius sizes. It has a wide range of applications, including chemical Aspects, biological aspects, etc., play a very important role. In addition to storing energy in living organisms, sugars are more importantly used ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/88G01N21/64
CPCC09K11/883C09K11/025G01N21/643
Inventor 盛家荣杨啟源黄珊肖琦朱琳琳邹修文乐秀秀孟荣
Owner GUANGXI TEACHERS EDUCATION UNIV
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