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A drug controlled release transdermal microneedle system with magnetocaloric effect and its preparation method and application

A technology of drug controlled release and magnetocaloric effect, which is applied in the field of medicine, can solve problems such as being easily affected by diet, difficult to control drug release behavior, and difficult absorption of macromolecular drugs, so as to improve drug delivery and release efficiency and reduce drug storage capacity. Control and improve the effect of drug therapy

Active Publication Date: 2020-03-20
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral medication has the following disadvantages: firstly, some drugs will have side effects on the gastrointestinal tract, and they are easily affected by diet; secondly, it is difficult to absorb macromolecular drugs, and more importantly, there are certain restrictions on oral administration for the elderly and children Limitations; on the other hand, injectable drugs can cause side effects due to the initial high concentration, but also cause safety problems due to infection, and require special training for medical staff, and can also cause pain in patients
There are many researched soluble microneedles based on organic polymer materials, and their release is based on the degradation of polymer materials in vivo. This degradation process is closely related to the biodegradability of the materials used, leading to drug release behavior is difficult to control

Method used

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  • A drug controlled release transdermal microneedle system with magnetocaloric effect and its preparation method and application
  • A drug controlled release transdermal microneedle system with magnetocaloric effect and its preparation method and application
  • A drug controlled release transdermal microneedle system with magnetocaloric effect and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0032] The drug controlled release transdermal microneedle system provided in this embodiment includes Fe embedded in the PCL. 3 o 4 Nanoparticles and the Mimetic Drug Rhodamine B. The preparation method of the drug controlled release transdermal microneedle system comprises the following steps:

[0033] Step 1, prepare the slurry: take 0.4g of PCL (polycaprolactone, a biopolymer material) and add it to an appropriate amount of chloroform, and seal it at room temperature for 4 hours to completely dissolve it in chloroform, and add 0.1g of Fe to the above solution 3 o 4 nanoparticles, stirred in a fume hood for 1-2h to make Fe 3 o 4 The nanoparticles are fully dispersed in the chloroform solution, and the solution is adjusted to an appropriate viscosity (5000~8000mPa.s).

[0034] Step 2, centrifugal casting molding: Add 0.2mL of the slurry in step 1 to the PDMS mold, centrifuge in a centrifuge at 4000rpm for 15min, take it out, then add 0.2mL of the slurry to the mold agai...

Embodiment 2

[0044] The drug controlled release transdermal microneedle system provided in this example is a drug controlled release transdermal microneedle system added with a low melting point monomer TMC to adjust the release performance on the basis of Example 1, and its preparation method is as follows:

[0045] Step 1, configure the slurry: take an appropriate amount of 0.3g PCL and add it to an appropriate amount of chloroform, and leave it sealed at room temperature for 4 hours to completely dissolve in chloroform, add 0.1g of TMC (trimethylene carbonate) and 0.1 g of Fe 3 o 4 Nanoparticles and drug Rhodamine B (2.5mg), stirred in a fume hood for 1-2h to make TMC and Fe 3 o 4 The nanoparticles are fully dispersed in the chloroform solution, and the solution is adjusted to an appropriate viscosity (5000~8000mPa.s);

[0046] Step 2, centrifugal casting molding: add 0.2mL of the slurry in step 1 to the PDMS mold, centrifuge in a centrifuge at 4000rpm for 15min, take it out; then ad...

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Abstract

The invention provides a medicine controlled release transdermal micro needle system with a magnetocaloric effect. The system comprises a base layer, the base layer is provided with a plurality of micro needles, the height of any needle ranges from 400[mu]m to 600[mu]m, the width of the tip segment of each micro needle ranges from 10[mu]m to 30[mu]m, the width of the bottom of each micro needle ranges from 200[mu]m to 400[mu]m, and any one from or a combination of the two of nano magnetic particles or trimethylene carbonate (TMC) is embedded in the base layer and the micro needles. The invention further provides a preparation method of the medicine controlled release transdermal micro needle system and an application of the medicine controlled release transdermal micro needle system in transdermal medicament conveying. According to the invention, the drug loading capacities of the transdermal drug-loading micro needles are high, multiple kinds of medicaments can be loaded, at the same time, the prepared transdermal micro needle system can adjust the release speed by changing the contents of the embedded nanometer magnetic particles and the TMC, the magnetocaloric effect is good, and dual efficacy of cooperation between medicament treatment and magnetocaloric treatment can be realized.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a medical device, in particular to a drug controlled-release transdermal microneedle system with magnetocaloric effect, a preparation method and application thereof. Background technique [0002] At present, the incidence of various diseases in the world shows a sharp upward trend. One of the important methods of clinical treatment at home and abroad is drug therapy, and the usual methods of drug delivery include oral medicine and injection medicine. However, oral medication has the following disadvantages: firstly, some drugs will have side effects on the gastrointestinal tract, and they are easily affected by diet; secondly, it is difficult to absorb macromolecular drugs, and more importantly, there are certain restrictions on oral administration for the elderly and children Limitations; on the other hand, injectable drugs can cause side effects due to the initial high concentra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00A61N2/10A61L31/06A61L31/02A61L31/14
CPCA61L31/028A61L31/06A61L31/14A61M37/0015A61M2037/0023A61M2037/0053A61M2037/0061A61M2205/02A61M2205/05A61M2205/3368A61N2/002A61N2/06C08L67/04
Inventor 朱钰方程纪伟
Owner UNIV OF SHANGHAI FOR SCI & TECH
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